...Pablo Sánchez-Martín; Masaaki Komatsu ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold protein involved in diverse cellular processes. Its functions are tightly regulated through an extensive pattern of post-translational modifications, and include the isolation...

... the autophagy receptor SQSTM1, facilitating inclusion body autophagy. Autophagy E3 ubiquitin ligase Inclusion bodies NEDD4 PB1 domain SQSTM1 p62 Ubiquitylation National Natural Science Foundation of China 10.13039/501100001809 81372208 81472558 SQSTM1 (p62) is an autophagic...

...Ke Chen; Jin Zeng; Haibing Xiao; Chunhua Huang; Junhui Hu; Weimin Yao; Gan Yu; Wei Xiao; Hua Xu; Zhangqun Ye ABSTRACT The signaling adaptor sequestosome 1 (SQSTM1)/p62 is frequently overexpressed in tumors and plays an important role in the regulation of tumorigenesis. Although great progress has...

... of galectin-8 leads to recruitment of autophagy adaptors like p62 (also known as SQSTM1), NDP52 (also known as CALCOCO2) and optineurin, which initiate the destruction of bacteria by xenophagy. Here, we show that the functionally barely characterized IFNγ- and TNFα-inducible ubiquitin-like modifier FAT10...

... and ATG2B, respectively. The isolation membranes could elongate in cells lacking ATG5, but did not mature into autophagosomes. We also found that ferritin clusters accumulated at the autophagosome formation site together with p62 (also known as SQSTM1) in autophagy-deficient cells. These results reveal...

... autophagosomal maturation ( Itoh et al., 2011 ). * Author for correspondence ( [email protected] ) © 2013. Published by The Company of Biologists Ltd 2013 ATG8 LC3 GABARAP LIR p62 Selective autophagy Macroautophagy (hereafter referred to as autophagy) is an intracellular...

... materials are selectively sequestered and degraded in the lysosomes. Substrate selection is mediated by ubiquitylation and recruitment of ubiquitin-binding autophagic receptors such as p62, NBR1, NDP52 and Optineurin. Although it has been shown that these receptors act cooperatively to target some types...

... regulation, apoptosis and cancer. Thirty-one percent of all identified proteins were categorized as putative covalently linked substrates. One of the identified proteins, the autophagosomal receptor p62/SQSTM1, was further investigated. p62 becomes covalently mono-FAT10ylated at several lysines, and FAT10...

... to the autophagosomal membrane. The N-terminal region was found to be important for interaction between LC3 and p62/SQSTM1 (hereafter termed p62). This interaction is dependent on the first 10 amino acids of LC3 and on specific residues located within the ubiquitin core. Knockdown of LC3 isoforms and overexpression...

...Manuel Portolés; Magdalena Faura; Jaime Renau-Piqueras; Francisco José Iborra; Rosana Saez; Consuelo Guerri; Joan Serratosa; Eulalia Rius; Oriol Bachs ABSTRACT We report here that a 62 kDa calmodulin-binding protein (p62), recently identified in the nucleus of rat hepatocytes, neurons and glial...