...Shinjinee Sengupta; Namrata Singh; Ajoy Paul; Debalina Datta; Debdeep Chatterjee; Semanti Mukherjee; Laxmikant Gadhe; Jyoti Devi; Yeshwanth Mahesh; Mohit Kumar Jolly; Samir K. Maji ABSTRACT p53 (also known as TP53) mutation and amyloid formation are long associated with cancer pathogenesis; however...

...Tatsuki Tsuruoka; Emiri Nakayama; Takuya Endo; Shingo Harashima; Rui Kamada; Kazuyasu Sakaguchi; Toshiaki Imagawa ABSTRACT The tumor suppressor p53 (also known as TP53) plays a central role in cellular stress responses by regulating transcription of multiple target genes. The temporal dynamics...

.... Under chemotherapeutic agent (such as arsenite, 5-Fu and VP-16) exposure, DAPK1 functions as a novel p53 (also known as TP53) kinase, which induces phosphorylation of p53 at Ser15 and transactivates the p53 target Ets-1, to synergistically repress IKKβ-dependent MDM2 stability, and ultimately removes...

...Yao Xiao; Mingliang Li; Teng Ma; Hao Ning; Libo Liu ABSTRACT AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial...

...Sun-Young Lee; Claire Robertson; Alexandra Diot; Valerie Meuray; Jean-Christophe Bourdon; Mina J. Bissell ABSTRACT Growing evidence indicates that p53 (encoded by TP53 ) has a crucial role in normal tissue development. The role of the canonical p53 (p53α) and its 12 isoforms in development...

... in PA development. Mutations of housekeeping genes frequently activate the p53 tumor suppressor protein ( Calo et al., 2018 ; Danilova et al., 2010 ). In the present study, depletion of Hspa8 also dramatically increased p53 protein expression levels ( Fig. 4 A). Next, we investigated whether...

...Ambuja Navalkar; Satyaprakash Pandey; Namrata Singh; Komal Patel; Debalina Datta; Bhabani Mohanty; Sachin Jadhav; Pradip Chaudhari; Samir K. Maji ABSTRACT Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation and amyloid formation of p53 is also implicated...

...Julianna Blagih; Michael D. Buck; Karen H. Vousden; Ana-Maria Lennon-Duménil ABSTRACT The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53 ) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has...

... requirement of both Pten and cyclin C in maintaining the levels of the p21 and p53 tumor suppressors (also known as CDKN1A and TP53, respectively) in thyroid tissue. In conclusion, these data reveal the first tumor suppressor role for cyclin C in a solid tumor model. In addition, this study uncovers new...

... through its histone chaperone activity. GRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11–MDM2–p53 axis. Here, we identified GRWD1-interacting proteins using a proteomics approach and showed that GRWD1 interacts with various proteins involved in transcription...

...Valentina Sladky; Fabian Schuler; Luca L. Fava; Andreas Villunger ABSTRACT The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD) and the pro-form of an endopeptidase...

.... Although the transcriptional activity of p53 (encoded by TP53 ) is known to be vital for senescence induction, the downstream effector genes critical for senescence remain unsolved. Recently, we have identified the proline dehydrogenase gene ( PRODH ) to be upregulated specifically in senescent cells...

... to 60S ribosomal subunit formation. Intriguingly, NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11–MDM2 complex, which activates the p53 pathway. Consequently, the growth of NML-depleted cells is suppressed in a p53...

... perturbation. Furthermore, there have been conflicting reports regarding the p53 dependency of nucleostemin activity and the cell cycle arrest profile of nucleostemin-depleted cells. In this Commentary, I propose a model that explains how the many contradictory observations surrounding nucleostemin can...

... the role of plakoglobin during tumorigenesis and metastasis, we expressed plakoglobin in human tongue squamous cell carcinoma (SCC9) cells and compared the mRNA profiles of parental SCC9 cells and their plakoglobin-expressing transfectants (SCC9-PG). We detected several p53-target genes whose levels were...

...Toshiaki Tanaka; Masashi Okada; Yasukazu Hozumi; Ken Tachibana; Chifumi Kitanaka; Yoshioki Hamamoto; Alberto M. Martelli; Matthew K. Topham; Mitsuyoshi Iino; Kaoru Goto Summary The transcription factor p53 plays a crucial role in coordinating the cellular response to various stresses. Therefore...

...Claudia Villicaña; Grisel Cruz; Mario Zurita Summary Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53...

... suppressor and interferon response factor (IRF)-1. Conversely, BAL1 enhances the expression of the proto-oncogenes IRF2 and B-cell CLL/lymphoma (BCL)-6 in DLBCL. Our results show for the first time that BAL1 represses the anti-proliferative and pro-apoptotic IFNγ–STAT1–IRF1–p53 axis and mediates...

... to functionally interact by as-yet-unknown mechanisms. We have delineated the mechanisms by which parkin controls DJ-1. Parkin modulates DJ-1 transcription and protein levels via a signaling cascade involving p53 and the endoplasmic reticulum (ER)-stress-induced active X-box-binding protein-1S (XBP-1S). Parkin...

...Giulio Donati; Elisa Brighenti; Manuela Vici; Giuliano Mazzini; Davide Treré; Lorenzo Montanaro; Massimo Derenzini The tumour suppressor p53 negatively controls cell cycle progression in response to perturbed ribosome biogenesis in mammalian cells, thus coordinating growth with proliferation...