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Keywords: p53
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Journal Articles
J Cell Sci (2021) 134 (11): jcs258316.
Published: 04 June 2021
...Ambuja Navalkar; Satyaprakash Pandey; Namrata Singh; Komal Patel; Debalina Datta; Bhabani Mohanty; Sachin Jadhav; Pradip Chaudhari; Samir K. Maji ABSTRACT Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation and amyloid formation of p53 is also implicated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs237453.
Published: 06 March 2020
...Julianna Blagih; Michael D. Buck; Karen H. Vousden; Ana-Maria Lennon-Duménil ABSTRACT The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53 ) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has...
Journal Articles
J Cell Sci (2019) 132 (16): jcs230029.
Published: 15 August 2019
... requirement of both Pten and cyclin C in maintaining the levels of the p21 and p53 tumor suppressors (also known as CDKN1A and TP53, respectively) in thyroid tissue. In conclusion, these data reveal the first tumor suppressor role for cyclin C in a solid tumor model. In addition, this study uncovers new...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs213009.
Published: 03 August 2018
... through its histone chaperone activity. GRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11–MDM2–p53 axis. Here, we identified GRWD1-interacting proteins using a proteomics approach and showed that GRWD1 interacts with various proteins involved in transcription...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3779–3787.
Published: 15 November 2017
...Valentina Sladky; Fabian Schuler; Luca L. Fava; Andreas Villunger ABSTRACT The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD) and the pro-form of an endopeptidase...
Journal Articles
J Cell Sci (2017) 130 (8): 1413–1420.
Published: 15 April 2017
.... Although the transcriptional activity of p53 (encoded by TP53 ) is known to be vital for senescence induction, the downstream effector genes critical for senescence remain unsolved. Recently, we have identified the proline dehydrogenase gene ( PRODH ) to be upregulated specifically in senescent cells...
Journal Articles
J Cell Sci (2016) 129 (12): 2382–2393.
Published: 15 June 2016
... to 60S ribosomal subunit formation. Intriguingly, NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11–MDM2 complex, which activates the p53 pathway. Consequently, the growth of NML-depleted cells is suppressed in a p53...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3885–3891.
Published: 15 September 2014
... perturbation. Furthermore, there have been conflicting reports regarding the p53 dependency of nucleostemin activity and the cell cycle arrest profile of nucleostemin-depleted cells. In this Commentary, I propose a model that explains how the many contradictory observations surrounding nucleostemin can...
Journal Articles
J Cell Sci (2013) 126 (14): 3031–3042.
Published: 15 July 2013
... the role of plakoglobin during tumorigenesis and metastasis, we expressed plakoglobin in human tongue squamous cell carcinoma (SCC9) cells and compared the mRNA profiles of parental SCC9 cells and their plakoglobin-expressing transfectants (SCC9-PG). We detected several p53-target genes whose levels were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2785–2797.
Published: 01 July 2013
...Toshiaki Tanaka; Masashi Okada; Yasukazu Hozumi; Ken Tachibana; Chifumi Kitanaka; Yoshioki Hamamoto; Alberto M. Martelli; Matthew K. Topham; Mitsuyoshi Iino; Kaoru Goto Summary The transcription factor p53 plays a crucial role in coordinating the cellular response to various stresses. Therefore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2502–2515.
Published: 01 June 2013
...Claudia Villicaña; Grisel Cruz; Mario Zurita Summary Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 1969–1980.
Published: 01 May 2013
... suppressor and interferon response factor (IRF)-1. Conversely, BAL1 enhances the expression of the proto-oncogenes IRF2 and B-cell CLL/lymphoma (BCL)-6 in DLBCL. Our results show for the first time that BAL1 represses the anti-proliferative and pro-apoptotic IFNγ–STAT1–IRF1–p53 axis and mediates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2124–2133.
Published: 01 May 2013
... to functionally interact by as-yet-unknown mechanisms. We have delineated the mechanisms by which parkin controls DJ-1. Parkin modulates DJ-1 transcription and protein levels via a signaling cascade involving p53 and the endoplasmic reticulum (ER)-stress-induced active X-box-binding protein-1S (XBP-1S). Parkin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 3017–3028.
Published: 01 September 2011
...Giulio Donati; Elisa Brighenti; Manuela Vici; Giuliano Mazzini; Davide Treré; Lorenzo Montanaro; Massimo Derenzini The tumour suppressor p53 negatively controls cell cycle progression in response to perturbed ribosome biogenesis in mammalian cells, thus coordinating growth with proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (23): 4076–4084.
Published: 01 December 2010
... for the destruction of intact mammalian proteins. The biological roles of REGγ and the underlying mechanisms are not fully understood. Here we provide evidence that REGγ regulates cellular distribution of p53 by facilitating its multiple monoubiquitylation and subsequent nuclear export and degradation. We also show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (8): 1203–1208.
Published: 15 April 2010
...Tim Krüger; Ulrich Scheer The tumor suppressor p53 has been implicated in the regulation of ribosome biogenesis based on its inhibitory effect on RNA polymerase I (pol I)-dependent transcription. Consistent with this, p53 has been described in nucleoli, albeit under specific experimental conditions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (8): 1295–1305.
Published: 15 April 2010
...Lauréline Roger; Laurent Jullien; Véronique Gire; Pierre Roux Mutations in the p53 tumour suppressor gene are associated clinically with tumour progression and metastasis. Downregulation of the E-cadherin cell-cell adhesion molecule is a key event for epithelial to mesenchymal transition (EMT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4208–4217.
Published: 15 November 2009
... case was FZR1 required for exit from mitosis, but in cells lacking FZR1, the G1 phase was shortened and the S phase was prolonged. In several normal and transformed human cell lines, loss of FZR1 function induced DNA-damage responses and impaired proliferation independently of the p53 status...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 4003–4008.
Published: 01 November 2009
... promoter transactivation. The opposite effect triggered by both presenilins was reminiscent of our previous study, which showed that these two proteins elicit antagonistic effects on p53. Therefore, we examined the contribution of p53 on Pen2 transcription. Pen2 promoter transactivation, and Pen2 mRNA...
Journal Articles
J Cell Sci (2009) 122 (16): 2989–2995.
Published: 15 August 2009
...Lily I. Huschtscha; Jonathan D. Moore; Jane R. Noble; Hamish G. Campbell; Janice A. Royds; Antony W. Braithwaite; Roger R. Reddel In normal cells, p53 protein is maintained at low levels, but the levels increase after stress or inappropriate growth signals to coordinate growth arrest or apoptosis...
Includes: Supplementary data