... activation of p38 MAPK; Smolen et al., 2000 ) and signalling downstream of the clustered L-selectin to drive pseudopod protrusion. We have recently shown in a THP-1 cellular model of monocytes that ezrin and moesin bind to L-selectin in a sequential manner; ezrin to drive signalling through putative...

...Alejandra Tomas; Sylwia Jones; Simon O. Vaughan; Daniel Hochhauser; Clare E. Futter ABSTRACT EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR...

... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...

...., 2007 ) and induces p38-dependent cell cycle arrest ( Kim et al., 2002 ). It is thus conceivable that arsenite inhibits cell proliferation through the p38–MK2-activated SAM checkpoint we describe here. In this study, we define a cell cycle checkpoint induced by SAM limitation and identify p38 MAPK...

... activates TACE via the phosphorylation of amino acid residue Tyr702 in the intracellular tail of TACE, resulting in increased TNFα release and p38 activation. Src inhibition or deficiency blocks stretch activation of the TACE–p38-MAPK signaling, resulting in impaired myogenic gene expression. In response...

... cancer JNK p38 MAPK PKC The activating transcription factor (ATF; also known as cAMP-dependent transcription factor) and cAMP-response-element-binding (CREB) families of transcription factors comprise 16 members of the activator protein 1 (AP1) transcription factor superfamily. ATF and CREB...

...-Jk was decreased by expression of PS2 in PS1 and PS2 double-knockout cells. We also found that PS1-knockout cells treated with a specific inhibitor of p38 mitogen-activated protein kinase ∂ (MAPK) had significantly increased levels of RBP-Jk. p38 MAPK phosphorylates RBP-Jk at Thr339 by physical...

... experiments. Fig. 4. p38 MAPK is activated in Scribble-knockdown cells surrounded by normal cells. ( A ) Immunofluorescence analyses of active p38 MAPK in MDCK-pTR Scribble shRNA cells within a monolayer of normal MDCK cells. CMFDA-labeled MDCK-pTR Scribble shRNA cells (green) were mixed...

... and dopamine, respectively. It has been shown that expression of Drosophila TH and Ddc is induced in various physiological and pathological conditions, including bacterial challenge; however, the mechanism involved has not been fully elucidated. Here, we show that ectopic activation of p38 MAPK induces TH...

...Anu Kukkonen-Macchi; Oana Sicora; Katarzyna Kaczynska; Christina Oetken-Lindholm; Jeroen Pouwels; Leena Laine; Marko J. Kallio The p38 mitogen-activated protein kinase (p38 MAPK) family, which is comprised of four protein isoforms, p38α, p38β, p38γ and p38δ, forms one of the key MAPK pathways...

... that might intersect with the canonical Wnt–β-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells. Wnt3a-induced p38 MAPK activation was sensitive to siRNAs against Gα q or Gα s , but not against either Gα o or Gα 11 . Activation...

... pathway replaces PI3K over time. By contrast, p38-MAPK-inhibited cells, or cells lacking MK2, were unable to polarize in response to fMLP. Long-term chemotaxis assays using a pan-PI3K inhibitor, a PI3Kδ-specific inhibitor or PI3Kγ-knockout neutrophils, demonstrated no role for PI3K in mediating chemotaxis...

...Mei Zhan; Bingwen Jin; Shuen-Ei Chen; James M. Reecy; Yi-Ping Li Skeletal muscle responds to mechanical stimulation by activating p38 MAPK, a key signal for myogenesis. However, the mechanotransduction mechanism that activates p38 is unknown. Here we show that mechanical stimulation of myoblasts...

... and p38 MAPK are both essential for successful myogenesis. Pro-myogenic growth factors such as IGF-II activate PI3-K via receptor tyrosine kinases but the extracellular cues and upstream intermediates required for activation of the p38 MAPK pathway in myoblast differentiation are not known. Initial...

... connections. Western blot analysis suggests that H 2 O 2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H 2 O 2 treatment. These results...

... to increases in mRNA levels that define LKs and is also a possible upstream regulator of ATF3. Phosphorylation of activation transcription factor 2 (ATF2) by JNK ( Cai et al., 2000 ; Yin et al., 1997 ; Zhang et al., 2001 ) and/or by p38 MAPK ( Fan et al., 2002 ) is reported to upregulate ATF3 expression...

... hyperphosphorylated and aggregated in a number of neurodegenerative diseases referred to as tauopathies. In this study, we identify and compare the residues in human Tau phosphorylated in vitro by all four p38 MAPK isoforms, and study the regulation of the phosphorylation of Thr50, under conditions where p38 MAPKs...

... and unexpected role for p38 MAPK inhibition in myogenesis and highlight the importance of the limb bud microenvironment in promoting the progression of limb myoblasts. To extend our analysis of the cartilage and muscle phenotypes observed following treatment with SB202190, we followed the endogenous activity...