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Keywords: p38 MAPK
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J Cell Sci (2021) 134 (3): jcs250340.
Published: 8 February 2021
... by p38 MAPK and PKC to promote ectodomain shedding . Biochem. J. 428 , 293 - 304 . 10.1042/BJ20091611 Kitaya , K. and Yasuo , T. ( 2009 ). Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16...
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J Cell Sci (2015) 128 (3): 487–498.
Published: 1 February 2015
... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...
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J Cell Sci (2014) 127 (1): 50–59.
Published: 1 January 2014
...., 2007 ) and induces p38-dependent cell cycle arrest ( Kim et al., 2002 ). It is thus conceivable that arsenite inhibits cell proliferation through the p38–MK2-activated SAM checkpoint we describe here. In this study, we define a cell cycle checkpoint induced by SAM limitation and identify p38 MAPK...
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J Cell Sci (2013) 126 (19): 4349–4357.
Published: 1 October 2013
... activates TACE via the phosphorylation of amino acid residue Tyr702 in the intracellular tail of TACE, resulting in increased TNFα release and p38 activation. Src inhibition or deficiency blocks stretch activation of the TACE–p38-MAPK signaling, resulting in impaired myogenic gene expression. In response...
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J Cell Sci (2012) 125 (12): 2815–2824.
Published: 15 June 2012
... cancer JNK p38 MAPK PKC The activating transcription factor (ATF; also known as cAMP-dependent transcription factor) and cAMP-response-element-binding (CREB) families of transcription factors comprise 16 members of the activator protein 1 (AP1) transcription factor superfamily. ATF and CREB...
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J Cell Sci (2012) 125 (5): 1296–1308.
Published: 1 March 2012
...-Jk was decreased by expression of PS2 in PS1 and PS2 double-knockout cells. We also found that PS1-knockout cells treated with a specific inhibitor of p38 mitogen-activated protein kinase ∂ (MAPK) had significantly increased levels of RBP-Jk. p38 MAPK phosphorylates RBP-Jk at Thr339 by physical...
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J Cell Sci (2012) 125 (1): 59–66.
Published: 1 January 2012
... experiments. Fig. 4. p38 MAPK is activated in Scribble-knockdown cells surrounded by normal cells. ( A ) Immunofluorescence analyses of active p38 MAPK in MDCK-pTR Scribble shRNA cells within a monolayer of normal MDCK cells. CMFDA-labeled MDCK-pTR Scribble shRNA cells (green) were mixed...
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J Cell Sci (2011) 124 (2): 216–227.
Published: 15 January 2011
...Anu Kukkonen-Macchi; Oana Sicora; Katarzyna Kaczynska; Christina Oetken-Lindholm; Jeroen Pouwels; Leena Laine; Marko J. Kallio The p38 mitogen-activated protein kinase (p38 MAPK) family, which is comprised of four protein isoforms, p38α, p38β, p38γ and p38δ, forms one of the key MAPK pathways...
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J Cell Sci (2008) 121 (21): 3598–3607.
Published: 1 November 2008
... that might intersect with the canonical Wnt–β-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells. Wnt3a-induced p38 MAPK activation was sensitive to siRNAs against Gα q or Gα s , but not against either Gα o or Gα 11 . Activation...
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J Cell Sci (2008) 121 (2): 205–214.
Published: 15 January 2008
... pathway replaces PI3K over time. By contrast, p38-MAPK-inhibited cells, or cells lacking MK2, were unable to polarize in response to fMLP. Long-term chemotaxis assays using a pan-PI3K inhibitor, a PI3Kδ-specific inhibitor or PI3Kγ-knockout neutrophils, demonstrated no role for PI3K in mediating chemotaxis...
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J Cell Sci (2005) 118 (16): 3695–3703.
Published: 15 August 2005
... connections. Western blot analysis suggests that H 2 O 2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H 2 O 2 treatment. These results...
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J Cell Sci (2005) 118 (15): 3471–3485.
Published: 1 August 2005
... to increases in mRNA levels that define LKs and is also a possible upstream regulator of ATF3. Phosphorylation of activation transcription factor 2 (ATF2) by JNK ( Cai et al., 2000 ; Yin et al., 1997 ; Zhang et al., 2001 ) and/or by p38 MAPK ( Fan et al., 2002 ) is reported to upregulate ATF3 expression...
Journal Articles
J Cell Sci (2005) 118 (2): 397–408.
Published: 15 January 2005
... hyperphosphorylated and aggregated in a number of neurodegenerative diseases referred to as tauopathies. In this study, we identify and compare the residues in human Tau phosphorylated in vitro by all four p38 MAPK isoforms, and study the regulation of the phosphorylation of Thr50, under conditions where p38 MAPKs...
Journal Articles
J Cell Sci (2003) 116 (14): 2885–2893.
Published: 15 July 2003
... and unexpected role for p38 MAPK inhibition in myogenesis and highlight the importance of the limb bud microenvironment in promoting the progression of limb myoblasts. To extend our analysis of the cartilage and muscle phenotypes observed following treatment with SB202190, we followed the endogenous activity...