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Keywords: p38 MAPK
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Journal Articles
J Cell Sci (2021) 134 (3): jcs250340.
Published: 08 February 2021
... to protect L-selectin from shedding when PECAM-1 is clustered. Activation of JNK would therefore be in conflict with synchronous activation of p38 MAPK, which primes L-selectin for shedding ( Killock and Ivetic, 2010 ). It is tempting to speculate that JNK activation could be transient, whereas activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2481–2490.
Published: 01 August 2017
...Alejandra Tomas; Sylwia Jones; Simon O. Vaughan; Daniel Hochhauser; Clare E. Futter ABSTRACT EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 487–498.
Published: 01 February 2015
... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 50–59.
Published: 01 January 2014
.... Here, we demonstrate that SAM limitation induced robust G1 arrest with high Cdk4 and low Cdk2 activity, which was independent from the mTORC1 and polyamine pathways, but depended on p38 MAPK and its downstream checkpoint kinase MAPK-activated protein kinase-2 (MK2, also known as MAPKAPK2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (19): 4349–4357.
Published: 01 October 2013
... activates TACE via the phosphorylation of amino acid residue Tyr702 in the intracellular tail of TACE, resulting in increased TNFα release and p38 activation. Src inhibition or deficiency blocks stretch activation of the TACE–p38-MAPK signaling, resulting in impaired myogenic gene expression. In response...
Journal Articles
J Cell Sci (2012) 125 (12): 2815–2824.
Published: 15 June 2012
... cancer JNK p38 MAPK PKC Although there are no reports of genetic changes in ATF2, altered ATF2 expression and/or activity have been implicated in several pathological conditions, including neurological diseases and cancer ( Chen et al., 2008 ; Pearson et al., 2005 ; Reimold et al., 1996...
Journal Articles
J Cell Sci (2012) 125 (5): 1296–1308.
Published: 01 March 2012
...-Jk was decreased by expression of PS2 in PS1 and PS2 double-knockout cells. We also found that PS1-knockout cells treated with a specific inhibitor of p38 mitogen-activated protein kinase ∂ (MAPK) had significantly increased levels of RBP-Jk. p38 MAPK phosphorylates RBP-Jk at Thr339 by physical...
Journal Articles
J Cell Sci (2012) 125 (1): 59–66.
Published: 01 January 2012
...). This is the first demonstration that an oncogenic transformation within an epithelium induces cell competition in a mammalian cell culture system. * Author for correspondence ( yasu@igm.hokudai.ac.jp ) 14 8 2011 © 2012. 2012 MDCK cells Scribble Cell competition p38 MAPK Since...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 3006–3016.
Published: 01 September 2011
... and dopamine, respectively. It has been shown that expression of Drosophila TH and Ddc is induced in various physiological and pathological conditions, including bacterial challenge; however, the mechanism involved has not been fully elucidated. Here, we show that ectopic activation of p38 MAPK induces TH...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (2): 216–227.
Published: 15 January 2011
...Anu Kukkonen-Macchi; Oana Sicora; Katarzyna Kaczynska; Christina Oetken-Lindholm; Jeroen Pouwels; Leena Laine; Marko J. Kallio The p38 mitogen-activated protein kinase (p38 MAPK) family, which is comprised of four protein isoforms, p38α, p38β, p38γ and p38δ, forms one of the key MAPK pathways...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3598–3607.
Published: 01 November 2008
... that might intersect with the canonical Wnt–β-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells. Wnt3a-induced p38 MAPK activation was sensitive to siRNAs against Gα q or Gα s , but not against either Gα o or Gα 11 . Activation...
Journal Articles
J Cell Sci (2008) 121 (2): 205–214.
Published: 15 January 2008
... pathway replaces PI3K over time. By contrast, p38-MAPK-inhibited cells, or cells lacking MK2, were unable to polarize in response to fMLP. Long-term chemotaxis assays using a pan-PI3K inhibitor, a PI3Kδ-specific inhibitor or PI3Kγ-knockout neutrophils, demonstrated no role for PI3K in mediating chemotaxis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 692–701.
Published: 15 February 2007
...Mei Zhan; Bingwen Jin; Shuen-Ei Chen; James M. Reecy; Yi-Ping Li Skeletal muscle responds to mechanical stimulation by activating p38 MAPK, a key signal for myogenesis. However, the mechanotransduction mechanism that activates p38 is unknown. Here we show that mechanical stimulation of myoblasts...
Journal Articles
J Cell Sci (2006) 119 (23): 4828–4840.
Published: 01 December 2006
... and p38 MAPK are both essential for successful myogenesis. Pro-myogenic growth factors such as IGF-II activate PI3-K via receptor tyrosine kinases but the extracellular cues and upstream intermediates required for activation of the p38 MAPK pathway in myoblast differentiation are not known. Initial...
Journal Articles
J Cell Sci (2005) 118 (16): 3695–3703.
Published: 15 August 2005
... connections. Western blot analysis suggests that H 2 O 2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H 2 O 2 treatment. These results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3471–3485.
Published: 01 August 2005
... and in vivo, ATF3 protein was upregulated, translocated to the nucleus of LKs, then downregulated in a transient window of expression between 2 and 12 hours after wounding (Figs 2 , 3 , 4 ). Phosphorylation of p38 MAPK and ATF2 was required for ATF3 expression in LKs of scrape wounds (Figs 5 and 6...
Journal Articles
J Cell Sci (2005) 118 (2): 397–408.
Published: 15 January 2005
... hyperphosphorylated and aggregated in a number of neurodegenerative diseases referred to as tauopathies. In this study, we identify and compare the residues in human Tau phosphorylated in vitro by all four p38 MAPK isoforms, and study the regulation of the phosphorylation of Thr50, under conditions where p38 MAPKs...
Journal Articles
J Cell Sci (2003) 116 (14): 2885–2893.
Published: 15 July 2003
... and unexpected role for p38 MAPK inhibition in myogenesis and highlight the importance of the limb bud microenvironment in promoting the progression of limb myoblasts. References Bader, D., Masaki, T. and Fischman, D. A. ( 1982 ). Immunochemical analysis of myosin heavy chain during avian myogenesis...