.... Highlighted Article: Neutrophil L-selectin co-clusters with PECAM-1 in cis during transendothelial migration (TEM). Clustering neutrophil PECAM-1 activates p38 MAPK and JNK to regulate L-selectin shedding, which in turn expedites TEM. PECAM-1 Diapedesis Transmigration p38 MAPK JNK...

...Alejandra Tomas; Sylwia Jones; Simon O. Vaughan; Daniel Hochhauser; Clare E. Futter ABSTRACT EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR...

... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...

... no competing interests. 24 01 2013 4 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Cell cycle MK2 One carbon cycle S -adenosylmethionine SAM p38 MAPK MAPKAPK2 In order to maintain DNA integrity and faithfully transmit genetic information, mammalian...

... activates TACE via the phosphorylation of amino acid residue Tyr702 in the intracellular tail of TACE, resulting in increased TNFα release and p38 activation. Src inhibition or deficiency blocks stretch activation of the TACE–p38-MAPK signaling, resulting in impaired myogenic gene expression. In response...

..., promote or potentiate one function of ATF2 over another. *Authors for correspondence: ( [email protected] ; [email protected] ) © 2012. Published by The Company of Biologists Ltd 2012 ATF2 Transcription DNA damage Mitochondria Melanoma Skin cancer JNK p38 MAPK PKC The activating...

...-Jk was decreased by expression of PS2 in PS1 and PS2 double-knockout cells. We also found that PS1-knockout cells treated with a specific inhibitor of p38 mitogen-activated protein kinase ∂ (MAPK) had significantly increased levels of RBP-Jk. p38 MAPK phosphorylates RBP-Jk at Thr339 by physical...

...). This is the first demonstration that an oncogenic transformation within an epithelium induces cell competition in a mammalian cell culture system. * Author for correspondence ( [email protected] ) 14 8 2011 © 2012. 2012 MDCK cells Scribble Cell competition p38 MAPK Since...

... and dopamine, respectively. It has been shown that expression of Drosophila TH and Ddc is induced in various physiological and pathological conditions, including bacterial challenge; however, the mechanism involved has not been fully elucidated. Here, we show that ectopic activation of p38 MAPK induces TH...

...Anu Kukkonen-Macchi; Oana Sicora; Katarzyna Kaczynska; Christina Oetken-Lindholm; Jeroen Pouwels; Leena Laine; Marko J. Kallio The p38 mitogen-activated protein kinase (p38 MAPK) family, which is comprised of four protein isoforms, p38α, p38β, p38γ and p38δ, forms one of the key MAPK pathways...

... that might intersect with the canonical Wnt–β-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells. Wnt3a-induced p38 MAPK activation was sensitive to siRNAs against Gα q or Gα s , but not against either Gα o or Gα 11 . Activation...

... pathway replaces PI3K over time. By contrast, p38-MAPK-inhibited cells, or cells lacking MK2, were unable to polarize in response to fMLP. Long-term chemotaxis assays using a pan-PI3K inhibitor, a PI3Kδ-specific inhibitor or PI3Kγ-knockout neutrophils, demonstrated no role for PI3K in mediating chemotaxis...

...Mei Zhan; Bingwen Jin; Shuen-Ei Chen; James M. Reecy; Yi-Ping Li Skeletal muscle responds to mechanical stimulation by activating p38 MAPK, a key signal for myogenesis. However, the mechanotransduction mechanism that activates p38 is unknown. Here we show that mechanical stimulation of myoblasts...

... and p38 MAPK are both essential for successful myogenesis. Pro-myogenic growth factors such as IGF-II activate PI3-K via receptor tyrosine kinases but the extracellular cues and upstream intermediates required for activation of the p38 MAPK pathway in myoblast differentiation are not known. Initial...

... connections. Western blot analysis suggests that H 2 O 2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H 2 O 2 treatment. These results...

... ; Zhang et al., 2001 ) and/or by p38 MAPK ( Fan et al., 2002 ) is reported to upregulate ATF3 expression in cell lines. We determined if activation of JNK or p38 MAPK was necessary for phosphorylation of ATF2 and elevation of ATF3 in LKs of scrape wounds. Confluent cultures of HKs were pretreated...

... hyperphosphorylated and aggregated in a number of neurodegenerative diseases referred to as tauopathies. In this study, we identify and compare the residues in human Tau phosphorylated in vitro by all four p38 MAPK isoforms, and study the regulation of the phosphorylation of Thr50, under conditions where p38 MAPKs...

... and unexpected role for p38 MAPK inhibition in myogenesis and highlight the importance of the limb bud microenvironment in promoting the progression of limb myoblasts. ‡ Author for correspondence (e-mail: [email protected] ) * Present address: Institute for Systems Biology, Seattle, WA, USA 98012...