... of cell migration by p27 (officially known as CDKN1B) has been reported, but the exact mechanism(s) whereby p27 interacts with downstream effectors that control cell migration have not been elucidated. By systematically comparing p27 +/+ mouse embryonic fibroblasts (MEFs) with genetically ablated p27...

... and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27 Kip1 – molecular events that are associated with CSN activity. The knockdown of tescalcin led...

...Lubna Nadeem; Jelena Brkic; Yangchun Frank Chen; Tung Bui; Sadia Munir; Chun Peng Summary p27 Kip1 , a cyclin-dependent kinase (CDK) inhibitor, is a multi-functional protein that regulates various cellular activities. Trophoblast proliferation, migration and invasion are some of the key processes...

... dependency, suggesting the presence of an uncharacterised cell-cycle checkpoint, which can be overridden by coexpression of oncogenic Ras. We report here that, although cyclin-CDK complexes persisted in suspension, proliferation was inhibited in LT-expressing cells by the CDK inhibitor p27 Kip1 (p27...

... of OLIG2 is induced by the Tet-off system. Induction of OLIG2 resulted in suppression of both the proliferation and anchorage-independent growth of U12-1. It also resulted in an increase in the expression of p27 Kip1 . A luciferase assay revealed that the CTF site of the p27 Kip1 gene promoter...

... of G 1 cdk activity, mediated in part by an increase in the cdk inhibitors p21 WAF1/Cip1 , p27 Kip1 and p16 Ink4a . Flow cytometric and immunoblot analysis demonstrated that the timing of the up-regulation of p27, p16 and p130 corresponds closely with the induction of the squamous-specific genes...