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Keywords: p21-activated kinase
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Journal Articles
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Cell cycle , Organelles
J Cell Sci (2024) 137 (21): jcs261948.
Published: 13 November 2024
... myosin receptor. Its timely breakdown terminates transport and results in the proper positioning of vacuoles in the bud. Vac17 breakdown is controlled by the bud-concentrated p21-activated kinase Cla4, and the E3-ubiquitin ligase Dma1. We found that the spindle position checkpoint kinase Kin4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (2): jcs261645.
Published: 30 January 2024
... Rho GTPase RhoU self-associates via its C-terminal extension. This interaction increases activation of downstream p21-activated kinases and regulates cell morphology, constituting a new mechanism of Rho GTPase regulation. RhoU Rho GTPases Cell morphology Phosphorylation p21-activated kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs207019.
Published: 6 March 2018
... APPL1 regulates α5β1 integrin and Rac activity through the GTPase Rab5. Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase National Institutes of Health 10.13039/100000002 GM092914 S10RR025524 R01GM117916 Ruth L...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (9): 1861–1872.
Published: 1 May 2005
... of RhoGTPases and regulate the actin cytoskeleton are unclear. Here we show that p21-activated-kinase 4 (PAK4) mediates morphological changes through its association with the Rho-family guanine nucleotide exchange factor (GEF), GEF-H1. We show that this association is dependent upon a novel GEF-H1 interaction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2002) 115 (20): 3947–3956.
Published: 15 October 2002
...Claire M. Wells; Arie Abo; Anne J. Ridley The p21-activated kinases (PAKs) are divided into two subgroups based on sequence homology. Group 1 PAKs (PAK1-3) are involved in cell migration, and are activated by pro-migratory stimuli and by Cdc42/Rac GTPases. In contrast,little is known about...
Includes: Multimedia, Supplementary data