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Keywords: p130Cas
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (7): 1263–1273.
Published: 1 April 2017
... targeting (FAT) domain. To determine the role of the FAT domain in these proteins, we compared wild-type exogenous NEDD9 with a hybrid construct in which the NEDD9 FAT domain had been exchanged for the p130Cas (also known as BCAR1) FAT domain. Fluorescence recovery after photobleaching (FRAP) revealed...
Journal Articles
J Cell Sci (2014) 127 (16): 3440–3450.
Published: 15 August 2014
... adhesion proteins is crucial for cells to communicate with the extracellular environment. However, the mechanisms that transmit actin cytoskeletal motion to the extracellular environment to drive cell migration are poorly understood. We find that the movement of p130Cas (Cas, also known as BCAR1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2647–2658.
Published: 15 June 2014
...-grade gliomas. DOK1 becomes tyrosine phosphorylated upon PDGF-BB stimulation of human glioma cells. Knockdown of DOK1 or expression of a DOK1 mutant (DOK1FF) containing Phe in place of Tyr at residues 362 and 398, resulted in inhibition of both the PDGF-BB-induced tyrosine phosphorylation of p130Cas...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1394–1405.
Published: 1 April 2014
...-associatied substrate Cas BCAR1 p130Cas Src family kinase SFK Actin dynamics Focal adhesion kinase FAK The Crk-associated substrate (Cas, p130Cas or BCAR1) is a prominent member of the Cas family of multidomain scaffolding proteins that are phosphorylated by major tyrosine kinases of the Abl...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (8): 1603–1611.
Published: 15 March 2004
... proposed in addition to the one at the genomic level. Estrogen has been described to activate c-Src kinase and this activation has been shown to be responsible for estrogen-dependent mitogenicity. A major substrate of c-Src kinase activity is the cytoskeletal protein p130Cas, originally identified in v-Src...