.... The irreversible growth arrest state in NHEKs is characterized by an accumulation of the hypophosphorylated forms of Rb and p130, with subsequent down-regulation of levels of Rb, up-regulation of p130 and associated down-regulation of E2F-regulated genes such as cyclin A. These events correlate with an inhibition...

... virus (RSV)-transformed cells. This protein forms a stable complex with pp60 src and is directly phosphorylated by activated forms of c- src . Using a monoclonal antibody (mAb 4F4) specific for the src -associated p130 we show that p130 is also phosphorylated in response to cell adhesion...