... Actin p120ctn Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/P007503/1 The morphogenesis of all tissues requires precise control over the shape of individual cells. In epithelia, which outlines all cavities and surfaces of animal bodies, a variety...

...René Keil; Christina Kießling; Mechthild Hatzfeld P0071 (plakophilin-4) is a member of the p120ctn subfamily of armadillo proteins that are essential for cell contact formation. Additionally, p0071 plays a role in cytokinesis, in which it regulates local activation of RhoA together with Ect2...

.... (B) To determine whether Kaiso and Importin-α2 form a complex in vivo, we performed coimmunoprecipitation experiments from HCT116 cell lysates with Kaiso- and Importin-α2-specific monoclonal antibodies. Importin-α2 co-precipitated weakly with endogenous Kaiso (lane 1) but not with p120ctn (lane 2...

.... This mutant possessed a double point mutation within the p120 ctn NLS as indicated. The images shown are representative of at least 100 cells scored for each construct. Bars, 20 μm. Fig. 1. Identification of an NLS in the p120ctn Armadillo domain. (A) A cross-species comparison of the p120ctn amino acid...

... β- and γ-catenin and p120 catenin (p120ctn). E-cadherin-mediated contact formation was shown to inhibit cellular motility. We examine whether p120ctn may have a role in this regulation. We show here that overexpression of p120ctn in fibroblasts and epithelial cells induces pronounced changes in cell...

... used, whereas exon C is used rarely. The splicing complicates the nomenclature. Isoforms are designated p120ctn 1-4, depending on the N-terminal start site. The A, B, and/or C designations are included if the exon is present (e.g. p120 ctn 1A, p120ctn1BC). The letter N (for none) is used if it is known...

... . Mol. Cell. Biol . 15 , 1175 – 1181 . Keirsebilck , A. , Bonne , S. , Staes , K. , van Hengel , J. , Nollet , F. , Reynolds , A. and van Roy , F. ( 1998 ). Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced...