...Ron C. J. Schackmann; Milou Tenhagen; Robert A. H. van de Ven; Patrick W. B. Derksen Summary The epithelial adherens junction is an E-cadherin-based complex that controls tissue integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as CTNND1). Mutational...

... of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating β-catenin. For example, in common with β-catenin, exogenous expression of destruction complex components, such as GSK3β and axin, promotes degradation of p120-catenin. Again in parallel with β...

... the extension of cadherin contacts through a phosphoinositide 3-kinase (PI 3-kinase)-Rac1 pathway. Cadherin adhesions were formed by PI 3-kinase-independent, Rac1-dependent co-recruitment of adhesion complexes and actin filaments. The expression and localization of p120 at the plasma membrane, associated...

...Agnes Roczniak-Ferguson; Albert B. Reynolds P120-catenin is the prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins involved in cell-cell adhesion. Interestingly, all members of the p120 subfamily have also been observed in the nucleus, suggesting that they have...

... the effect of v-Src expression on E-cadherinmediated adhesion. The aggregation of L cells expressing the wild-type or EαC chimeric protein, which both interact with p120 ctn , was reduced by v-Src expression, whereas that of L cells expressing the tail-less E-cadherin was not affected by the expression...

... of proteins into the junctional plaque. Among these junctional plaque proteins are members of the armadillo gene family, β-catenin, plakoglobin (γ-catenin), B6P/plakophilin and p120. These proteins are assumed to play a key role in cell cell signalling through intercellular junctions. Here we report cloning...