...-induced direct DNA damage, such as thymine dimers, cause the initial PARP activation, whereas ultraviolet B-induced oxidative damage cause the second PARP activation. Our results suggest that cells can selectively activate PARP for participation in different cellular responses associated with different...

... and the exacerbation of iron-induced oxidative damage to DNA. We demonstrate that H-rich ferritin is present in the nucleus of human astrocytoma tumor cells. To study the mechanism and regulation of ferritin translocation to the nucleus,we developed a cell culture model using SW1088 human astrocytoma cells. Changes...

... 09 1999 17 11 1999 © 1999 by Company of Biologists 1999 Programmed cell death Apoptosis Radiation Radiosensitivity Cell cycle Development Central nervous system Retina Oxidative damage Free radical Antioxidant Cell death induced by ionizing radiation can occur...