... mutants were used to investigate the role of BMPR1A and BMPR1B in chondrogenesis and osteogenesis. We found that BMPR1A is necessary for chondrogenesis and osteogenesis, and BMPR1B prevents hypertrophy. GDF5 BMP2 M1673 Chondrogenesis Hypertrophy Osteogenesis Bone morphogenetic proteins...

... an immortalized human mesenchymal stromal cell (MSC) line model, we show that both N - and O-glycan processing in the Golgi functionally modulates early steps of osteogenic differentiation. We found that inhibiting O-glycan processing in the Golgi prior to the start of osteogenesis inhibited the mineralization...

... that modulate adhesion, cytoskeleton remodeling and differentiation. Although it is well recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive FA maturation, actin organization and stress fiber polarization, the extent to which FA-mediated signals regulated by the FA protein...

... the architectural effects of the in vivo microenvironment and also for the therapeutic use of stem cells. * Author for correspondence ( [email protected] ) 14 10 2011 © 2012. 2012 Cell differentiation Mesenchymal stem cells Osteogenesis Nanotopography Surface functionalization...

..., such as dexamethasone, promote osteoblastic differentiation in several in vitro model systems. The mechanism by which these hormones induce osteogenesis remains poorly understood. We demonstrate here that the coordinate action of dexamethasone and the osteogenic transcription factor Runx2/Cbfa1 synergistically induces...

... with bone morphogenetic proteins (BMPs), a treatment that induces osteogenic differentiation, suggesting that MyoD has a role in BMP-induced osteogenesis of myogenic cells. This possibility is supported by our observations that muscle satellite cells derived from adult MyoD -/- mice show severely impaired...

... bone formation, which unfolds in a precisely defined spatial and temporal frame * Author for correspondence (e-mail: [email protected] ) 1 4 2003 © The Company of Biologists Limited 2003 2003 Osteoprogenitors Osteogenesis Chondrogenesis Bone-marrow stromal cells...

... Osteogenesis Mesenchymal cells Dedifferentiation Redifferentiation © The Company of Biologists Limited 2002 2002 11 9 2002 * Author for correspondence (e-mail: [email protected] ) We have recently shown that ES cells differentiate into chondrocytes in vitro...

... plays a role in pericyte differentiation and bone formation. * Author for correspondence 25 08 1995 14 11 1995 © 1996 by Company of Biologists 1996 Pericyte Thrombospondin Osteogenesis Differentiation It is still not clear how mineralisation and bone formation...

...Eleanor J. Mackie; Richard P. Tucker ABSTRACT The extracellular matrix glycoprotein, tenascin, is associated in vivo with mesenchyme undergoing osteogenesis and chondrogenesis, but is absent from mature bone and cartilage matrix. The expression of tenascin by osteoblastic cells in vitro has been...

..., demonstrate an inverse relationship between the differentiation of adipocytic and osteogenic cells in this culture system and are consistent with the possibility that the regulation of adipogenesis and osteogenesis can occur at the level of a common precursor in vivo . * Author for correspondence...

... of Biologists 1991 marrow adipocytes fibroblasts osteogenesis Cells with fibroblastic and adipocytic characteristics together with macrophages and endothelial cells are often included in descriptions of marrow stromal cell populations ( Dexter, 1982 ). Recently it has been proposed...

... 1990 23 07 1990 © 1990 by Company of Biologists 1990 pericytes osteogenesis differentiation calcification microvasculature Pericytes are defined by their location in vivo within the basement membrane of venules, arterioles and capillaries ( Kuwabara and Cogan, 1963...

... status for osteogenesis, it seems likely that a large proportion of CFU-F in the present cultures are early stem and progenitor cells of the stromal system. The main effect of EG F in the present experiments was to increase average colony size concomitant with depression of AP activity to negligible...