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Keywords: nucleus
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Journal Articles
J Cell Sci (2021) 134 (6): jcs253021.
Published: 26 March 2021
...Sanju Ashraf; Ye Dee Tay; David A. Kelly; Kenneth E. Sawin ABSTRACT Movement of the cell nucleus typically involves the cytoskeleton and either polymerization-based pushing forces or motor-based pulling forces. In the fission yeast Schizosaccharomyces pombe , nuclear movement and positioning...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... is sensed and how its effects are transduced into the nucleus remain key open questions. As cartilage tissue and chondrocytes are reported to be incompressible under low strains ( Bachrach et al., 1998 ; Ofek et al., 2009 ), a pressure-sensing mechanism in the absence of a gas–liquid interface remains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs252544.
Published: 09 November 2020
... of adenovirus (AdV) infection. AdV delivers, transcribes and replicates a linear double-stranded DNA genome in the nucleus. We measured the abundance of viral transcripts using single-molecule RNA fluorescence in situ hybridization (FISH) and the incoming 5-ethynyl-2′-deoxycytidine (EdC)-tagged viral genomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
...Justin T. Jacob; Raji R. Nair; Brian G. Poll; Christopher M. Pineda; Ryan P. Hobbs; Michael J. Matunis; Pierre A. Coulombe ABSTRACT Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs235911.
Published: 14 November 2019
... (0.079) suggesting that, at very high N/C ratios, nuclear growth ceases. Average cellular and nuclear growth rates were calculated for cohorts of time bins assigned into cohorts by nucleus or cell volume at the start of the bin. Cellular growth rate correlated with both the cell ( Fig. 4 E) and nucleus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
...Tiina Viita; Salla Kyheröinen; Bina Prajapati; Jori Virtanen; Mikko J. Frilander; Markku Varjosalo; Maria K. Vartiainen ABSTRACT In addition to its essential functions within the cytoskeleton, actin also localizes to the cell nucleus, where it is linked to many important nuclear processes from gene...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs218479.
Published: 29 October 2018
... used experimental systems as well as in vivo . In this Hypothesis, we highlight known examples of intracellular mechanical challenges in biological systems and focus on the coping mechanisms of two important organelles, the nucleus and mitochondria, for they are the best studied in this aspect...
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
... or their cleaved cytoplasmic domains. In cancer cells, these nuclear functions contribute to tumor progression and drug resistance. Here, we examined whether the single Drosophila EGFR can also localize to the nucleus. A chimeric EGFR protein fused at its cytoplasmic C-terminus to DNA-binding and transcriptional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs216556.
Published: 27 July 2018
...Cédric Yapo; Anu G. Nair; Jeanette Hellgren Kotaleski; Pierre Vincent; Liliana R. V. Castro ABSTRACT Although it is known that protein kinase A (PKA) in the nucleus regulates gene expression, the specificities of nuclear PKA signaling remain poorly understood. Here, we combined computational...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211094.
Published: 13 April 2018
... for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation . Biochem. J.   248 , 765 - 770 . 10.1042/bj2480765 Dieck , C. B. , Wood , A. , Brglez , I. , Rojas-Pierce , M. and Boss , W. F. ( 2012 ). Increasing phosphatidylinositol (4,5) bisphosphate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2926–2940.
Published: 01 September 2017
... events given that the analysis requires components from many cells. Microscopy can visualize single cells, but the cell body and organelles can hamper staining and visualization of the nucleus. Normally, chromatin is visualized by immunostaining a fixed sample or by expressing exogenous fluorescently...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (14): 2243–2250.
Published: 15 July 2017
... role of cell adhesion receptors in this process is established, it has only recently been appreciated that mechanical cues reach far beyond the plasma membrane and the cytoskeleton, and are directly transmitted to the nucleus. Furthermore, changes in the mechanical properties of the perinuclear...
Journal Articles
J Cell Sci (2017) 130 (12): 2066–2077.
Published: 15 June 2017
.... This demonstrated the importance of image analysis to enhance super-resolution techniques. Structured illumination microscopy Image analysis Chromatin Nucleus Histone modification Nuclear pore complexes The nuclear periphery (NP) represents a complex compartment of substantial importance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3412–3425.
Published: 15 September 2016
...Leonid A. Serebryannyy; Megan Parilla; Paolo Annibale; Christina M. Cruz; Kyle Laster; Enrico Gratton; Dmitri Kudryashov; Steven T. Kosak; Cara J. Gottardi; Primal de Lanerolle ABSTRACT Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 1981–1988.
Published: 15 May 2016
... provided that the original work is properly attributed. Summary: We find that nuclear translocation of paxillin is tuned by focal adhesion maturation. This could provide a method for mechanosensing signals to be used by cells to control transcription. FAT domain Focal adhesion Nucleus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1115–1127.
Published: 15 March 2016
... to impact on nuclear size, and we propose that NTF2 might be a new cancer biomarker. Nucleus NTF2 Nuclear transport Ran Nuclear pore complex Nuclear structure Xenopus Cancer Melanoma Development Nuclear size Nuclear scaling Cell size varies when comparing different species and tissue...
Journal Articles
J Cell Sci (2016) 129 (2): 314–328.
Published: 15 January 2016
... species induce dephosphorylation of pTyr23AnxA2 located in the PML bodies of the nucleus, whereas AnxA2 associated with F-actin at the cell cortex is Tyr23 phosphorylated. The H 2 O 2 -induced responses in both compartments are transient and the pTyr23AnxA2 accumulating at the cell cortex is subsequently...
Journal Articles
J Cell Sci (2015) 128 (24): 4475–4486.
Published: 15 December 2015
...Filipe V. Almeida; Gernot Walko; James R. McMillan; John A. McGrath; Gerhard Wiche; Asa H. Barber; John T. Connelly ABSTRACT The transmission of mechanical forces to the nucleus is important for intracellular positioning, mitosis and cell motility, yet the contribution of specific components...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3607–3620.
Published: 01 October 2015
... Dechat , T. , Pfleghaar , K. , Sengupta , K. , Shimi , T. , Shumaker , D. K. , Solimando , L. and Goldman , R. D. ( 2008 ). Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin . Genes Dev.   22 , 832 - 853 . 10.1101/gad...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2388–2400.
Published: 01 July 2015
... RNAi screen is used to identify several conserved regulators of nuclear actin import and polymerization, and thus links control of nuclear actin to many cellular processes. Actin Nucleus Cofilin RNA interference Actin is a multifunctional protein in both the cytoplasm and the nucleus...
Includes: Supplementary data