...Kristi McElmurry; Jessica E. Stone; Donghan Ma; Phillip Lamoureux; Yueyun Zhang; Michelle Steidemann; Lucas Fix; Fang Huang; Kyle E. Miller; Daniel M. Suter ABSTRACT Previously, we have shown that bulk microtubule (MT) movement correlates with neurite elongation, and blocking either dynein activity...

... an interaction with a G protein pathway complex (GPC) comprising Gα i/o , GAP-43 and G protein regulated inducer of neurite outgrowth 1 (Gprin1) in differentiating cells. Morphological studies indicate that α7 receptors regulate neurite length and complexity via a Gprin1-dependent mechanism that directs...

...Violet Votin; W. James Nelson; Angela I. M. Barth Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood. A candidate protein for controlling neurite extension...

... the tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), Shc, and c-Cbl and also their interaction with ALK and activation of ERK1/2. Furthermore, we show that continuous incubation with mAb16-39 induces the cell growth and neurite outgrowth of SK-N-SH cells. These responses are completely blocked...

... only expressed RAR α and β. When retinoic acid was added to each of the neuronal classes only the NGF and NT-3 dependent neurons responded by extending neurites, and this response involved the upregulation of RAR β 2 . This specificity was confirmed by the use of receptor-selective agonists as only...

... co-distribute with α3β1 integrin on neurites and growth cones of human NT2N cells. Also, stable CD151-α3β1 and CD81-α3β1 complexes were recovered in NT2N detergent lysates. Total NT2N neurite outgrowth on laminin-5 (a ligand for α3β1 integrin) was strongly inhibited by anti-CD151 and -CD81 antibodies...

... for neurite outgrowth of PC12 cells induced by nerve growth factor (NGF). Microinjection of a constitutively active mutant of PI-3 kinase induced process formation suggesting that PI-3 kinase is indeed involved in the neurite outgrowth. However, the processes appeared to be incomplete neurites as they had...

...Phillip R. Gordon-Weeks ABSTRACT Growth cones are transient structures present at the tips of growing axons and dendrites (neurites). They are crucial to neuronal development because of their pathfinding ability and their role in synaptogenesis (reviewed by Dodd and Jessell, 1988 ). In the last few...

...Kristine Lewandowska; Enrica Balza; Luciano Zardi; Lloyd A. Culp ABSTRACT Some neuron-derived cells, such as neuroblastoma cells, adhere and extend neurites on fibronectin (FN) substrata by processes that can be independent of binding to the Arg-Gly-Asp-Ser sequence (RGDS in FN) and independent...