... to dissect nutritional genotoxicity, providing insight into how phagocytosis can induce mutagenesis and compromise survival fitness. Cancer Research UK 10.13039/501100000289 13647 The DNA damage response is highly conserved and prevents the accumulation of deleterious DNA damage after...

... regulates Rad18-mediated template switch . Nature   456 , 915 - 920 . Broomfield   S. , Hryciw   T. , Xiao   W. ( 2001 ). DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae . Mutat. Res.   486 , 167 - 184 . Chen   I. P. , Mannuss   A. , Orel   N...

... phototoxicity and can probe deeper into biological tissues. Perhaps the most dramatic development on this front has been the introduction of new FPs derived from mRFP1 through directed mutagenesis targeting chromophore residues that are known to play a key role in determining the spectral characteristics ( Fig...

... a drastic effect on the affinity for leptin. The D615A mutation in CRH2 breaks a predicted salt bridge with K5 in leptin and has a pronounced negative effect on leptin binding and receptor signalling. Structural and functional analysis of binding site I in growth hormone/receptor complex by mutagenesis...

... University, Halifax, Nova Scotia, Canada 25 03 1996 10 07 1997 © 1997 by Company of Biologists 1997 APL PML RING finger Mutagenesis Nuclear body PML nuclear bodies are nuclear multi-protein complexes which are distinct from other sub-nuclear structures ( Nickerson et...

... Mutagenesis Dimerization Subcellular localization Estrogen receptor Yeast viability Fig. 1. Schematic representation of Hsp90WT and mutants: non denaturing gel filtration and native PAGE data. The two hydrophilic regions A and B, the central leucine zipper region Z, and the epitopes of antibodies...

...Simon J. Atkinson; Murray Stewart ABSTRACT Complementation of alternating zones of positive and negative charge in the myosin rod enables molecules to interact in a number of ways. This accounts for the complexity of the molecular organisation of thick filaments. However, directed mutagenesis...

... for correspondence 14 09 1989 23 11 1989 © 1990 by Company of Biologists 1990 coronavirus Golgi lysosomes mutagenesis Proteins destined for the plasma membrane of eukaryotic cells generally reach their destination via the membranes of the endoplasmic reticulum (ER) and Golgi...

... at the endogenous thrombin site near the middle of the N-terminal non-helical domain of GFAP. A shorter 1047 bp fragment, in which the C-terminal non-helical domain of GFAP was deleted, was also produced using oligonucleotide-directed sitespecific mutagenesis of the original cDNA clone. After proteolysis...