... muscle. Damage was [Ca]- and time-dependent and it is suggested that it is probably the active movement of Ca ions across key membrane sites that is critical in triggering damage of the myofilament apparatus. Strontium can substitute for Ca at higher concentrations. The action of saponin suggests...

.... * Author for correspondence 02 10 1986 05 11 1986 © 1987 by Company of Biologists 1987 muscle damage phospholipase A 2 lipoxygenase calcium Damage to tissues is known to occur in a variety of pathological conditions and a considerable amount of work has been undertaken...