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Keywords: mitosis
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Journal Articles
J Cell Sci jcs.261733.
Published: 21 May 2024
.... However, mechanistical understanding of mitosis and cytokinesis in dinoflagellate remains rudimentary. Using an optimized immunofluorescence protocol, we analysed changes in microtubule organization occurring during the mitotic cycle of the toxic dinoflagellate Ostreopsis cf. ovata. We find that the two...
Journal Articles
J Cell Sci (2024) 137 (9): jcs261744.
Published: 13 May 2024
... and to the centrosome, spindle midzone and bridging fiber area, and midbodies during mitosis. Loss of DPF3 causes kinetochore fiber instability, unstable kinetochore–microtubule attachment and defects in chromosome alignment, resulting in altered mitotic progression, cell death and genomic instability. In addition, we...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (11): jcs261014.
Published: 8 June 2023
... cohesion establishment and mitotic cohesion dissolution have been extensively explored, the regulation of cohesin loading is still poorly understood. Here, we report that the methyltransferase NSD3 is essential for mitotic sister chromatid cohesion before mitosis entry. NSD3 interacts with the cohesin...
Includes: Supplementary data
Journal Articles
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Cell cycle
J Cell Sci (2023) 136 (10): jcs260458.
Published: 31 May 2023
... both with and without cell cycle synchronization. We found that single-cell pHi is dynamic throughout the cell cycle: pHi decreases at G1/S, increases in mid-S, decreases at late S, increases at G2/M and rapidly decreases during mitosis. Importantly, although pHi is highly dynamic in dividing cells...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2023) 136 (6): jcs260266.
Published: 20 March 2023
... previously reported that protocadherin 7 (PCDH7) gets enriched at the cell surface during mitosis, which is required to build up the full mitotic rounding pressure. Here, we report that PCDH7 interacts with and is palmitoylated by the palmitoyltransferase, ZDHHC5. PCDH7 and ZDHHC5 colocalize at the mitotic...
Includes: Supplementary data
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Journal Articles
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Cell cycle , Motors
J Cell Sci (2023) 136 (5): jcs260528.
Published: 6 March 2023
...Carolyn M. Remsburg; Kalin D. Konrad; Jia L. Song ABSTRACT Mitosis is a fundamental and highly regulated process that acts to faithfully segregate chromosomes into two identical daughter cells. Localization of gene transcripts involved in mitosis to the mitotic spindle might be an evolutionarily...
Includes: Supplementary data
Journal Articles
In collection:
Cell cycle , Motors
J Cell Sci (2023) 136 (5): jcs220269.
Published: 2 March 2023
... attachments during mitosis . J. Biol. Chem. 293 , 5755 - 5765 . 10.1074/jbc.AAC118.004421 Auckland , P. , Roscioli , E. , Coker , H. L. E. and McAinsh , A. D. ( 2020 ). CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes . J...
Includes: Supplementary data
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Cytoskeleton
J Cell Sci (2023) 136 (2): jcs260152.
Published: 19 January 2023
...-regulating sequences, correlate with colorectal cancer. The cellular roles of APC in mitosis are widely studied, but the molecular mechanisms of its interaction with the cytoskeleton are poorly understood. Here, we investigated how APC-C regulates microtubule properties, and found that it promotes both...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (2): jcs260124.
Published: 17 January 2023
... and segregated, and, consequently, mitosis resumes. Therefore, we followed the above procedure of cold treatment and release to observe kinetochore (marked by Cnp3–tdTomato) dynamics. As shown in Fig. 6 C,D, 75% of mhf2 + cells (versus 36.8% of mhf2 Δ cells) displayed normal chromosome segregation during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (5): jcs260226.
Published: 8 November 2022
.... Kinetochore Mitosis Lis1 Dynein Microtubule King's College London Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/T008709/1 Accurate mitotic progression requires that chromosomes capture spindle microtubules and form...
Includes: Supplementary data
Journal Articles
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Plant cell biology
J Cell Sci (2022) 135 (19): jcs260127.
Published: 29 September 2022
... work is properly attributed. Summary: Expression of TAN1 in the root meristematic zone rescues cell-file-rotation defects in tan1 air9 mutant plants, suggesting that defects that occur in mitosis influence the organization of non-dividing cells. Mitosis Phragmoplast Root twisting...
Includes: Supplementary data
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In collection:
Cell cycle
J Cell Sci (2022) 135 (18): jcs259657.
Published: 23 September 2022
...Kehan Xu; Chunxue Wang; Kari Keinänen; Hong Li; Chunlin Cai ABSTRACT Swift and complete spindle disassembly in late mitosis is essential for cell survival, yet how it happens is largely unknown in mammalian cells. Here we used real-time live cell microscopy and biochemical assays to show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (17): jcs260031.
Published: 30 August 2022
... upregulation compromised mitotic spindle integrity and induced aneuploidy via micronuclei formation. Chromosomal instability Aneuploidy Micronuclei KIF11 Mitosis CRISPR activation Confocal imaging Machine learning Deep learning Cancer Research UK http://dx.doi.org/10.13039/501100000289...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (12): jcs259626.
Published: 21 June 2022
...Souradeep Basu; James O. Patterson; Theresa U. Zeisner; Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs255802.
Published: 10 June 2022
...Eugenia Almacellas; Caroline Mauvezin ABSTRACT Lysosomes exert pleiotropic functions to maintain cellular homeostasis and degrade autophagy cargo. Despite the great advances that have boosted our understanding of autophagy and lysosomes in both physiology and pathology, their function in mitosis...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2023) 136 (5): jcs260144.
Published: 31 May 2022
...Toni McHugh; Julie P. I. Welburn ABSTRACT The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (9): jcs259344.
Published: 6 May 2022
...) is a protein known to be involved in cortical domain remodeling. Here, we report that in HeLa cell early mitosis, Anx2 recruits the scaffold protein Ahnak at the cell cortex facing spindle poles, and the distribution of both proteins is controlled by cell adhesion. Depletion of either protein or impaired...
Includes: Supplementary data
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Cilia and flagella
J Cell Sci (2022) 135 (8): jcs259120.
Published: 21 April 2022
... of distal and subdistal appendages one-and-a-half cell cycles later, as they exit their second mitosis. Current models postulate that the centriolar protein centrobin acts as placeholder for distal appendage proteins that must be removed to complete distal appendage formation. Here, we investigated, in non...
Includes: Supplementary data