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Keywords: mitosis
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Journal Articles
J Cell Sci (2022) 135 (12): jcs259626.
Published: 21 June 2022
...Souradeep Basu; James O. Patterson; Theresa U. Zeisner; Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs255802.
Published: 10 June 2022
...Eugenia Almacellas; Caroline Mauvezin ABSTRACT Lysosomes exert pleiotropic functions to maintain cellular homeostasis and degrade autophagy cargo. Despite the great advances that have boosted our understanding of autophagy and lysosomes in both physiology and pathology, their function in mitosis...
Journal Articles
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Cytoskeleton
J Cell Sci (2023) 136 (5): jcs260144.
Published: 31 May 2022
...Toni McHugh; Julie P. I. Welburn ABSTRACT The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (9): jcs259344.
Published: 6 May 2022
...) is a protein known to be involved in cortical domain remodeling. Here, we report that in HeLa cell early mitosis, Anx2 recruits the scaffold protein Ahnak at the cell cortex facing spindle poles, and the distribution of both proteins is controlled by cell adhesion. Depletion of either protein or impaired...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (8): jcs259120.
Published: 21 April 2022
... of distal and subdistal appendages one-and-a-half cell cycles later, as they exit their second mitosis. Current models postulate that the centriolar protein centrobin acts as placeholder for distal appendage proteins that must be removed to complete distal appendage formation. Here, we investigated, in non...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (7): jcs259648.
Published: 14 April 2022
... Effler , J. C. , Kee , Y.-S. , Berk , J. M. , Tran , M. N. , Iglesias , P. A. and Robinson , D. N. ( 2006 ). Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape . Curr. Biol. 16 , 1962 - 1967 . 10.1016/j.cub.2006.08.027 Faix...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (4): jcs259532.
Published: 18 February 2022
... to resist microtubule pulling forces during mitosis. One hallmark of the pericentromere is the enrichment of the structural maintenance of chromosome (SMC) proteins cohesin and condensin. Based on studies from population approaches (ChIP-seq and Hi-C) and experimentally obtained images of fluorescent probes...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (3): jcs258745.
Published: 2 February 2022
...-kinetochore microtubules. Dissection of the dynamics of microtubule populations provides a greater understanding of mitotic spindle kinetics and insight into their roles in facilitating chromosome attachment, movement and segregation during mitosis. To target interdigitating interpolar microtubules, Eg5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259273.
Published: 18 January 2022
...Thomas Tischer; Jing Yang; David Barford ABSTRACT The control of protein abundance is a fundamental regulatory mechanism during mitosis. The anaphase-promoting complex/cyclosome (APC/C) is the main protein ubiquitin ligase responsible for the temporal regulation of mitotic progression. It has been...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2021) 134 (21): jcs258856.
Published: 2 November 2021
..., but they must be inherited from mother cells into buds during budding yeast mitosis. We report that this process occurs in a preferred sequence. Budding yeast Mitosis Endoplasmic reticulum Peroxisome, Vacuole Mitochondria, Nucleus Organelle segregation National Institute of General Medical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs247171.
Published: 9 September 2021
...Takanobu Moriuchi; Fumiko Hirose ABSTRACT Dephosphorylation of lamin A, which triggers nuclear lamina reconstitution, is crucial for the completion of mitosis. However, the specific phosphatase and regulatory mechanism that allow timely lamin A dephosphorylation remain unclear. Here, we report...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs249763.
Published: 3 August 2021
... in mitotic mammalian tissue cells . J. Cell Biol. 153 , 517 - 527 . 10.1083/jcb.153.3.517 Cimini , D. , Moree , B. , Canman , J. C. and Salmon , E. D. ( 2003 ). Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs255018.
Published: 29 July 2021
... attributed. Summary: Mouse embryonic stem cells display asymmetric divisions in 3D colonies, with cell–cell junctions and cell geometry acting as key regulators of division symmetry. 3D cell division E-cadherin Embryonic stem cells Mitosis Spindle positioning Medical Research...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (13): jcs258382.
Published: 12 July 2021
... of genes encoding presenilin lead to familial forms of Alzheimer's disease. We propose the sea urchin embryo as a model to study the expression of presenilin Presenilin PSEN Sea urchin Development Mitosis Calcium Presenilins (PSENs) are transmembrane proteins that play both proteolysis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (13): jcs249771.
Published: 8 July 2021
... activity is regulated remains largely unclear. Here, using in vivo and in vitro assays, we report that conjugation of SUMO2 with AurA at K258 in early mitosis promotes the kinase activity of AurA and facilitates the binding with its activator Bora. Knockdown of the SUMO proteases SENP3 and SENP5 disrupts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (10): jcs255844.
Published: 20 May 2021
... were not properly fragmented at mitosis and were partitioned asymmetrically to daughter cells. Respiratory functions of mitochondria were impaired and ROS generation was enhanced. On a cellular level, cell proliferation, cytokinesis and cell–matrix adhesion were negatively affected. On a molecular...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (4): jcs258356.
Published: 19 February 2021
.... J. , Copeland , R. A. et al . ( 2007 ). Binding of TPX2 to Aurora A alters substrate and inhibitor interactions . Biochemistry 46 , 10287 - 10295 . 10.1021/bi7011355 Asare , A. , Levorse , J. and Fuchs , E . ( 2017 ). Coupling organelle inheritance with mitosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs251769.
Published: 11 February 2021
... onset of mitosis. Gene deletions that advance cells into mitosis at a smaller size or delay cells entering mitosis have led to the identification of genes potentially involved in this mechanism. However, the molecular basis of this control is still not understood. In this work, we have screened...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (3): jcs255794.
Published: 1 February 2021
... and clathrin, but not each other. We also show that PIK3C2A, a clathrin-binding protein that was proposed to stabilize the TACC3–chTOG–clathrin–GTSE1 complex during mitosis, is not a member of the complex. This work establishes that targeting the TACC3–clathrin interface or their microtubule-binding sites...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (2): jcs255950.
Published: 27 January 2021
... in processes such as ciliogenesis. Human CDC14 Mitosis Cytokinesis DNA damage Ciliogenesis CDC14 encodes an essential highly conserved dual specificity protein phosphatase that in budding yeast Saccharomyces cerevisiae promotes mitotic exit, the transition from mitosis into G1 phase...
Includes: Supplementary data