... and zebrafish embryos. Mitochondria Respiration Cardiomyocyte hypertrophy Zebrafish Phenylephrine Pyruvate Uridine University Grants Commission http://dx.doi.org/10.13039/501100001501 MAY2018-353734 201610094029 NOV2017-341658 Science and Engineering Research Board http...

...Antigoni Diokmetzidou; Luca Scorrano ABSTRACT Mitochondrial contact sites are specialized interfaces where mitochondria physically interact with other organelles. Stabilized by molecular tethers and defined by unique proteomic and lipidomic profiles, these sites enable direct interorganellar...

... row cells. Adhesion Integrin Extracellular matrix Cell migration Mitochondria Morphogenesis National Institutes of Health http://dx.doi.org/10.13039/100000002 R35-GM131865 T32-GM008136 T32-GM007267 R25-HL088724 F30-HD111307 University of Virginia http...

... functional protein level and translating ribosomes, giving insight into how these unique particles regulate mitochondrial biology in Drosophila . Clu Drosophila Ribonucleoprotein Cycloheximide Translation Mitochondria University of Iowa http://dx.doi.org/10.13039/100008893...

...Eleonora Zilio; Tim Schlegel; Marta Zaninello; Elena I. Rugarli ABSTRACT Mitochondria are dynamic and heterogeneous organelles that rewire their network and metabolic functions in response to changing cellular needs. To this end, mitochondria integrate a plethora of incoming signals to influence...

...Laurie P. Lee-Glover; Martin Picard; Timothy E. Shutt ABSTRACT As we have learned more about mitochondria over the past decades, including about their essential cellular roles and how altered mitochondrial biology results in disease, it has become apparent that they are not just powerplants pumping...

... interactors MAPL, ATAD1 and TRABD. We show that TRABD is likely involved in carrier protein translocation. Mitochondria Mitochondrial biogenesis Protein transport TOM complex Mitochondrial quality control Mitochondrial protein import Ministry for Science and Culture of Lower Saxony http...

...Kailash Venkatraman; Nicolas-Frédéric Lipp; Itay Budin ABSTRACT Unique membrane architectures and lipid building blocks underlie the metabolic and non-metabolic functions of mitochondria. During eukaryogenesis, mitochondria likely arose from an alphaproteobacterial symbiont of an Asgard archaea...

...Corey N. Cunningham; Jonathan G. Van Vranken; Jakeline Larios; Katarina Heyden; Steven P. Gygi; Jared Rutter ABSTRACT Mitochondria perform diverse functions, including producing ATP through oxidative phosphorylation, synthesizing macromolecule precursors, maintaining redox balance among many others...

... resistance in pathogens including C. neoformans emphasize the need to find new drugs. Mitochondria have long been associated with drug resistance in fungi. They are connected to the endoplasmic reticulum (ER) via a multiprotein complex, the ER–mitochondria encounter structure (ERMES), which is unique...

...Nathaniel Shannon; Cory Raymond; Chloe Palmer; Silver Homa; Marcelo Bonini; David Seward; Brian Cunniff ABSTRACT Mitochondrial positioning supports localized energy and signaling requirements. Miro1 is necessary for attachment of mitochondria to microtubule motor proteins for trafficking. When...

.... Mitochondrial dysfunction plays a key role in the pathogenesis of myocardial ischemia and reperfusion injury. Dysfunctional mitochondria can be removed by mitophagy, culminating in their degradation within acidic lysosomes. Mitophagy is pivotal in maintaining cardiac homeostasis and emerges as a potential...

...)–mitochondria contact sites and mitochondrial cristae structure. The mitochondrial intermembrane bridging (MIB) complex connects the outer and inner mitochondrial membranes at the cristae junction through the mitochondrial contact site and cristae organization system (MICOS). However, the interaction between...

... to promote organelle function. Here, we examined two well-characterized mitochondria–endoplasmic reticulum (ER) MCSs – the ER–mitochondria encounter structure (ERMES) and the mitochondria–ER–cortex anchor (MECA) in Saccharomyces cerevisiae . We report that loss of MECA results in a substantial reduction...

... lacking Alo1 exhibited defects in mitochondrial morphology and inheritance. During oxidative stress, dysfunctional mitochondria are immobilized in the mother in wild-type cells. Intriguingly, overexpression of ALO1 restored bud-directed transport of mitochondria under these conditions. We propose...

.... , Morini , M. F. , Zacchetti , D. , Grohovaz , F. and Codazzi , F. ( 2011 ). Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity . Aging Cell 10 , 172 - 183 . 10.1111/j.1474-9726.2010.00652.x Pelizzoni , I...

... subunit of BORC. RAS dysregulated cancer cells rely on a high turnover of mitochondria due to their susceptibility to oxidative stress-induced damage; likewise, NF1- deficient tumor cells with RAS dysregulation might also require rapid mitochondrial turnover. Although autophagy is utilized...

... at MCSs. We show, using simultaneous measurements of Ca 2+ concentration in the cytosol and mitochondrial matrix, that KRAP also licenses IP 3 Rs to release Ca 2+ to mitochondria. Loss of KRAP abolishes cytosolic and mitochondrial Ca 2+ signals evoked by stimulation of IP 3 Rs via endogenous receptors...

... of mitochondria. Conversely, overexpression of GTPBP8 shifted mitochondrial morphology from tubular to fragmented. Notably, the induced mitochondrial fragmentation from GTPBP8 overexpression was inhibited in cells either depleted of the mitochondrial fission protein Drp1 (also known as DNM1L) or carrying mutated...

...Claire Caron; Giulia Bertolin ABSTRACT Mitochondria are multifunctional organelles of key importance for cell homeostasis. The outer mitochondrial membrane (OMM) envelops the organelle, and the inner mitochondrial membrane (IMM) is folded into invaginations called cristae. As cristae composition...