...Johannes F. Weijman; Laura Vuolo; Caroline Shak; Anna Pugnetti; Aakash G. Mukhopadhyay; Lorna R. Hodgson; Kate J. Heesom; Anthony J. Roberts; David J. Stephens ABSTRACT Primary cilia are essential eukaryotic organelles required for signalling and secretion. Dynein-2 is a microtubule-motor protein...

... understood. This Review discusses these fascinating enigmas. Retrograde trafficking Microtubule motors Lipid asymmetry Extracellular vesicle Morphogenesis Myelination Deutscher Akademischer Austauschdienst http://dx.doi.org/10.13039/501100001655 US-BI_BI-5026 Deutsche...

... transport Microtubule motors Summary: We discuss current understanding of the cytoplasmic dynein-2 microtubule motor, and its roles in cilia assembly and function. © 2020. Published by The Company of Biologists Ltd 2020 Competing interests The authors declare no competing or financial...

... the N-terminus, which can interact with kinases of the JNK pathway and p38 MAPK pathway to signal for growth, differentiation and apoptosis (Whitmarsh, 2006). In addition to signaling factors, JIPs interact with microtubule motors. All of the JIPs have been found to interact with kinesin-1 (Verhey et al...

... from the active site of the directly bound head via its central β-sheet to the tethered head. * Author for correspondence (e-mail: [email protected]) 3 10 2007 © The Company of Biologists Limited 2007 2007 Cryo-electron microscopy Image reconstruction Microtubule motors...

... transporters motility microtubule motors Cytoplasmic dynein is a minus end-directed microtubule-associated motor protein (Paschal and Vallee, 1987). It has been implicated in retrograde axonal transport and movements of organelles, such as lysosomes and endosomes, towards the minus ends...

... and implicate this motor enzyme in Golgi structure, function and dynamics. * Author for correspondence 24 03 1994 09 05 1994 © 1994 by Company of Biologists 1994 liver microtubule motors immunofluorescence transcytotic carriers It is well documented that the Golgi...

... simply as a consequence of motor protein activity, but are stable domains that appear to be enriched in active microtubule motors. Negative stain electron microscopy reveals that the motile globular domains associated with the RER networks are generally smaller than those observed in networks derived...

... superfamily peptide antibody microtubule motors Numerous KLPs have thus been identified at the nucleic acid level using genetic techniques or the PCR (polymerase chain reaction), but we know of no reports of the biochemical identification and isolation of KLPs from their native cell type. Here we...