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Keywords: microRNA
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (19): jcs261286.
Published: 11 October 2023
...Parisa Naeli; Xu Zhang; Patric Harris Snell; Susanta Chatterjee; Muhammad Kamran; Reese Jalal Ladak; Nick Orr; Thomas Duchaine; Nahum Sonenberg; Seyed Mehdi Jafarnejad ABSTRACT Viruses use microRNAs (miRNAs) to impair the host antiviral response and facilitate viral infection by expressing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (17): jcs259783.
Published: 7 September 2022
... is differentially required to regulate valve development. MicroRNA Valvulogenesis Conditional knockout Heart development National Institutes of Health R01HL095783 Congenital heart diseases (CHDs) occur in as many as 1–5% of newborns and remain the leading noninfectious cause...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (12): jcs257535.
Published: 21 June 2021
... effector proteins that reduce RNA polymerase II activity on genes required for neurogenesis. miR-26b regulates neurogenesis in zebrafish by targeting ctdsp2 mRNA, but the molecular events triggered by this microRNA (miR) remain unknown. Here, we show in a murine embryonic stem cell differentiation paradigm...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (12): jcs258575.
Published: 17 June 2021
...-inducible factors (HIFs). Among many determinants dictating cell responses to hypoxia and HIFs are microRNAs (miRNAs). Cajal bodies (CBs), subnuclear structures involved in ribonucleoprotein biogenesis, have been recently proven to contribute to miRNA processing and biogenesis but have not been studied...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs202317.
Published: 26 March 2018
... fibrosis but the driving force in the perpetuation stage is only partially understood. To date, some investigations have specifically identified overexpression of microRNA 21 (miR-21) in the progression of kidney fibrosis. Nevertheless, the precise role of miR-21 in fibroblast activation remains largely...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (12): 2314–2327.
Published: 15 June 2015
... the function of microRNAs (miRNAs) and small interfering RNAs (siRNAs) during meiosis in males, we generated germ-cell-specific conditional deletions of Dgcr8 and Dicer in mice. Analysis of spermatocytes from both conditional knockout lines revealed that there were frequent chromosomal fusions during meiosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 293–304.
Published: 15 January 2015
...William W. Du; Xianmin Li; Tianbi Li; Haoran Li; Azam Khorshidi; Fengqiong Liu; Burton B. Yang ABSTRACT The microRNA miR - 17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 70–80.
Published: 1 January 2015
...Wendong Fan; Rong Fang; Xiaoyuan Wu; Jia Liu; Mingzhe Feng; Gang Dai; Guojun Chen; Guifu Wu ABSTRACT Although many studies have described the roles of microRNAs (miRNAs) in the modulation of the endothelial response to shear stress, the mechanisms remain incompletely understood. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1585–1594.
Published: 1 April 2014
... expression and increased expression of the linc-RoR target microRNA-145 (miR-145). Linc-RoR was highly expressed in extracellular RNA released by hepatocellular cancer (HCC) cells during hypoxia. Incubation with extracellular vesicle preparations containing extracellular RNA increased linc-RoR, HIF-1α...
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (12): 2678–2691.
Published: 15 June 2013
... cells located beneath the basal lamina of the myofiber, and are the principal cellular source of growth and regeneration in skeletal muscle. MicroRNAs (miRNAs) play key roles in modulating several cellular processes by targeting multiple mRNAs that comprise a single or multiple signaling pathway...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2012) 125 (24): 6117–6126.
Published: 15 December 2012
... of sGC is obligatory for the biological stability and activity of the sGC heterodimer. MicroRNAs (miRNAs) are important regulators of gene expression and exert great influences on diverse biological activities. The aim of the present study was to determine whether or not the expression of sGCβ 1...
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (18): 4179–4787.
Published: 15 September 2012
... of generating pluripotent stem cells. Here, we discuss recent findings that show that, in addition to transcription factors, microRNAs can promote pluripotent reprogramming and can even substitute for these pluripotency transcription factors in some cases. Taking into consideration that microRNAs have...
Journal Articles
J Cell Sci (2012) 125 (15): 3590–3600.
Published: 1 August 2012
...Katarzyna Goljanek-Whysall; Helio Pais; Tina Rathjen; Dylan Sweetman; Tamas Dalmay; Andrea Münsterberg Summary MicroRNAs are short non-coding RNAs involved in post-transcriptional regulation of multiple messenger RNA targets. The miR-1/miR-206 family is expressed during skeletal muscle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2709–2720.
Published: 1 June 2012
...Clément Bellemer; Marie-Line Bortolin-Cavaillé; Ute Schmidt; Stig Mølgaard Rask Jensen; Jørgen Kjems; Edouard Bertrand; Jérôme Cavaillé Nuclear primary microRNA (pri-miRNA) processing catalyzed by the DGCR8–Drosha (Microprocessor) complex is highly regulated. Little is known, however, about how...
Includes: Multimedia, Supplementary data