... miRNA Mouse Nicotinic acetylcholine receptors nAChR Cell culture Fluorescence Neuromuscular junction Dystrophin complex National Institute of Neurological Disorders and Stroke http://dx.doi.org/10.13039/100000065 R01NS111041 University of Michigan http://dx.doi.org...

...Bartika Ghoshal; Edouard Bertrand; Suvendra N. Bhattacharyya ABSTRACT MicroRNAs (miRNAs), the tiny regulators of gene expression, can be transferred between neighbouring cells via extracellular vesicles (EVs) to control the expression of genes in both donor and recipient cells. How the EV-derived...

...Susanta Chatterjee; Yogaditya Chakrabarty; Saikat Banerjee; Souvik Ghosh; Suvendra N. Bhattacharyya ABSTRACT Defective intracellular trafficking and export of microRNAs (miRNAs) have been observed in growth-retarded mammalian cells having impaired mitochondrial potential and dynamics. Here, we...

... postnatally, lifelong plasticity facilitates stimulus-dependent adaptation. Functional adaptation requires molecular adaptation, which is partially provided by miRNA-mediated post-transcriptional regulation. miR-206 is a muscle-specific miRNA enriched in slow muscles. We investigated whether miR-206 drives...

... applied in several studies involving disease models, drug screening and cellular replacement therapies. However, the somatic reprogramming by transcription factors is a low-efficiency process. Moreover, the reprogramming process is also regulated by microRNAs (miRNAs), which modulate the expression...

...) granules. RNP granules assemble through a concentration-dependent liquid–liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain...

... that Gliotactin levels are also regulated at the mRNA level by micro (mi)RNA-mediated degradation and that miRNAs are targeted to a short region in the 3′UTR that includes a conserved miR-184 target site. miR-184 also targets a suite of septate junction proteins, including NrxIV, coracle and Mcr. miR-184...

... diseases. Endothelial cell Endothelial dysfunction Endothelial–mesenchymal transition EndMT Fibroblast growth factor FGF MicroRNA miRNA Transforming growth factor beta TGFβ Netherlands Organisation for Health Research and Development 10.13039/501100001826 916.11.022 40-00506-98...

... largely unknown. Intriguingly, we found that the dynamin (DNM) genes, a GTPase family of proteins responsible for endocytosis in eukaryotic cells, encode the conserved miR-199a and miR-199b family of miRNAs within their intronic sequences. Here, we demonstrate that miR-199a and miR-199b regulate endocytic...

...Luba Farberov; Eytan Herzig; Shira Modai; Ofer Isakov; Amnon Hizi; Noam Shomron MicroRNAs (miRNAs) are short non‐coding RNAs that play a central role in the regulation of gene expression by binding to target mRNAs. Several studies have revealed alterations in cellular miRNA profiles following HIV‐1...

... polyadenylation and reverse transcription of all miRs within the sample into cDNA in a single reaction step. Individual miRs were then detected using LNA-enhanced miRNA-specific primer sets (Exiqon) for hsa-miR-145 (target sequence: 5′-GUCCAGUUUUCCCAGGAAUCCCU-3′) or 5S rRNA. miR expression was quantified against...

... in obstructed kidney. This study reveals a new mechanism whereby microvesicle-mediated communication of miRNA between fibroblasts and tubular cells is involved in regulating tubular cell apoptosis, which might provide new therapeutic targets for renal tubulointerstitial fibrosis. * These authors...

... system for studying the molecular signaling pathways underlying beta cell differentiation, as well as a potential source of cells for the treatment of type 1 diabetes. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate many biological processes, including cellular differentiation. We...

...Biao Yan; Ban Liu; Chang-Dong Zhu; Kang-Le Li; Li-Jia Yue; Jin-Liang Zhao; Xiao-Ling Gong; Cheng-Hui Wang Summary MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play crucial roles in numerous biological processes. However, the role of miRNAs in skin color determination in fish has...

...Lihi Ninio-Many; Hadas Grossman; Noam Shomron; Dana Chuderland; Ruth Shalgi Summary Fyn, a member of the Src family kinases (SFKs), has a pivotal role in cell adhesion, proliferation, migration and survival, and its overexpression is associated with several types of cancer. MicroRNAs (miRNAs) play...

...Stephanie B. Greene; Preethi H. Gunaratne; Scott M. Hammond; Jeffrey M. Rosen In an effort to understand the potential role of microRNAs (miRNAs) in mammary-gland stem or progenitor cells, miRNA microarrays were performed on subpopulations of the mouse mammary epithelial cell (MEC) line COMMA-DβGeo...