... of Biologists 1999 Dystrophin Dystroglycan Merosin Laminin Myotube Duchenne muscular dystrophy (DMD) is a progressive, X-linked disease with an incidence of around 1/3500, one third of which are sporadic with no previous family history ( Emery, 1993 ). Both DMD and the more benign Becker...

... to a doublet of 350-380 kDa, which was subsequently found in both cell extracts and conditioned culture media. This thyroid laminin variant was compared with merosin, another variant found in the basement membranes of tro-phoblast, Schwann cells, striated muscle and liver. The heavy chain (M) of merosin shows...

...-laminin promotes neurite outgrowth also from embryonic mammalian RGC, in contrast to previous reports, and that these exhibit similar agedependent growth responses on laminin. Antibody blocking studies show that this behaviour is mediated in mouse RGC by 㯁6β1 integrin dimers. The laminin isoform merosin...