...). In this cell line, and other similar hybrids, malignancy, as measured by progressive growth in vivo , is suppressed; and it has been shown that the keratinocyte imposes its own programme of terminal differentiation on the non-malignant hybrid cell. In particular, involucrin, a precursor of one of the major...

...Michael C. Copeman; Henry Harris ABSTRACT It has been shown that when malignant tumour cells are fused with normal fibroblasts the suppression of malignancy in the hybrids is linked to their ability to produce a collagenous extracellular matrix in vivo . When, as a consequence of chromosome loss...