... mitochondrial localization. Moreover, inserting a mutation that generates a stop codon in the coding sequence, specifically within the mitochondria-targeting signal (MTS), which is important for mRNA localization ( Eliyahu et al., 2010 ; Lesnik et al., 2014 ), yielded a similar outcome and decreased...

... Summary: An aggregation–dissolution model for the temporal and spatial control of mRNA translation is found for Pum1-mediated control in mouse oocytes. Pumilio 1 Vertebrate mRNA localization Oocyte Meiosis Translational control Takeda Science Foundation 10.13039/100007449...

... in the Gap43 -depleted cultures ( Fig. 6 E). siRNAs targeting a different region of Gap43 generated similar results, with increased localization of GFP MYR 3′nrn1 upon depletion of Gap43 from these neurons (data not shown). These results show that the 3′UTR of Nrn1 can drive axonal mRNA localization...

... and robust, the localization activity of individual transport signals is weak. Notably, increasing the strength of individual transport signals, or adding a strong transport signal, disrupts the later stages of oskar mRNA localization. We propose that the oskar transport signals are weak by necessity...

... synthesized proteins into the membrane. Endoplasmic reticulum mRNA localization Secretion Tail-anchored protein One major mechanism that directs proteins to their correct subcellular destination is localization of their mRNA ( Holt and Bullock, 2009 ; Martin and Ephrussi, 2009 ). Likely...

..., we have identified enzymes that are involved in phospholipid metabolism. Loss of the phospholipid methyltransferase Cho2p, which showed the strongest impact on mRNA localization, disturbs mRNA localization, as well as ER morphology and segregation, owing to an increase in the amount of cellular...

... localization to Pbodies requires Bfr1p. Images of bfr1 mutant strains containing Dcp2pCFP and MS2tagged RPS16A , VNX1 or TDP1 . The mRNA and Dcp2p localization is shown after A no starvation, B 10minutes of glucose starvation, C 50 minutes of glucose starvation. Scale bars 5 m. Fig. 6. Latephase mRNA...

... and maintain a persistent and directional motility. * Authors for correspondence ( [email protected] ; [email protected] ) 21 8 2011 © 2012. 2012 Cancer cell invasion Post-transcriptional regulation mRNA localization In the early stages of metastasis, cancer cells...

...-mail: [email protected] ) 31 01 2000 01 12 1999 © 2000 by Company of Biologists 2000 Amphoterin HMG-1 mRNA localization RAGE Cell migration Amphoterin (p30) is a developmentally regulated heparin-binding protein that is abundantly expressed in embryonic brain...