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Keywords: mRNA
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Journal Articles
In collection:
Proteostasis
J Cell Sci (2023) 136 (10): jcs261216.
Published: 23 May 2023
...Alison J. Inglis; Alina Guna; Ángel Gálvez-Merchán; Akshaye Pal; Theodore K. Esantsi; Heather R. Keys; Evgeni M. Frenkel; Robert Oania; Jonathan S. Weissman; Rebecca M. Voorhees ABSTRACT Translation of mRNAs containing premature termination codons (PTCs) results in truncated protein products...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (18): jcs259156.
Published: 28 September 2021
...Kiril Tishinov; Anne Spang ABSTRACT mRNA decay is a key step in regulating the cellular proteome. Processing bodies (P-bodies) are thought to be sites of mRNA decay and/or storage. P-body units assemble into P-body granules under stress conditions. How this assembly is regulated, however, remains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs239756.
Published: 8 April 2020
...Marc Oudart; Romain Tortuyaux; Philippe Mailly; Noémie Mazaré; Anne-Cécile Boulay; Martine Cohen-Salmon ABSTRACT Astrocytes are morphologically complex and use local translation to regulate distal functions. To study the distribution of mRNA in astrocytes, we combined mRNA detection via in situ...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 4 May 2018
...) experiments showed that ACA mRNA is also asymmetrically distributed at the back of polarized cells. By using the MS2 bacteriophage system, we now visualize the distribution of ACA mRNA in live chemotaxing cells. We found that the ACA mRNA localization is not dependent on the translation of the protein product...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (21): 4692–4701.
Published: 1 November 2014
... (EJC), which is loaded onto spliced mRNAs and plays an essential role in determining their fate. Unlike the three other EJC core components [eIF4AIII, Magoh and Y14 (also known as RBM8A)], MLN51 is mainly located in the cytoplasm, where it plays a key role in the assembly of stress granules...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2127–2133.
Published: 15 May 2014
...Richard M. Parton; Alexander Davidson; Ilan Davis; Timothy T. Weil ABSTRACT mRNA localisation coupled to translational regulation provides an important means of dictating when and where proteins function in a variety of model systems. This mechanism is particularly relevant in polarised...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2014) 127 (9): 1992–2004.
Published: 1 May 2014
...Julie Weidner; Congwei Wang; Cristina Prescianotto-Baschong; Alejandro F. Estrada; Anne Spang ABSTRACT Numerous mRNAs are degraded in processing bodies (P bodies) in Saccharomyces cerevisiae . In logarithmically growing cells, only 0–1 P bodies per cell are detectable. However, the number...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (12): 2551–2560.
Published: 15 June 2013
...Yiwen Fang; John F. Bateman; Julian F. Mercer; Shireen R. Lamandé Summary Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved mRNA surveillance system that degrades mRNA transcripts that harbour a premature translation-termination codon (PTC), thus reducing the synthesis of truncated...
Journal Articles
J Cell Sci (2011) 124 (2): 228–239.
Published: 15 January 2011
...J. Ross Buchan; Je-Hyun Yoon; Roy Parker Eukaryotic cells respond to cellular stresses by the inhibition of translation and the accumulation of mRNAs in cytoplasmic RNA–protein (ribonucleoprotein) granules termed stress granules and P-bodies. An unresolved issue is how different stresses affect...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (21): 4467–4478.
Published: 1 November 2003
.... In situ hybridization showed that poly(A) mRNA is abundant and non-uniformly distributed in nearly all axons. The specific transcripts for β-actin and actin-depolymerizing factor (ADF) were also present and non-uniformly distributed in axons, with an approximately hundredfold higher concentration...
Journal Articles
J Cell Sci (2003) 116 (4): 587–597.
Published: 15 February 2003
..., mRNAs and snRNAs, are specifically directed into distinct but in some cases partially overlapping nuclear export pathways. All non-coding RNAs are now known to depend on members of the karyopherin family of Ran-dependent nucleocytoplasmic transport factors for their nuclear export. In contrast, mRNA...
Journal Articles
J Cell Sci (1998) 111 (21): 3157–3166.
Published: 1 November 1998
... documented that the protein synthetic activity of squid optic lobe synaptosomes is largely due to the presynaptic terminals of the photoreceptor neurons. The identification of ribosomes and poly(A + )-mRNA in the plaques indicates that these structures are sites of local protein synthesis in synaptic domains...
Journal Articles
J Cell Sci (1995) 108 (8): 2781–2790.
Published: 1 August 1995
... fluorescence in situ hybridization and immunofluorescence in conjunction with dual channel confocal laser scanning microscopy. Arginyl-tRNA synthetase, elongation factor 1a, ribosomal RNA, and myelin basic protein mRNA were all co-localized in granules in the processes, veins and membrane sheets of the cell...
Journal Articles
J Cell Sci (1995) 108 (7): 2629–2644.
Published: 1 July 1995
...). The results indicated that 12(S)-HETE transcriptionally activates the gene expression of integrin αv as assessed by quantitative reverse transcription/polymerase chain reaction/Southern hybridization, RNase protection assay, solution hybridization, and northern blotting. The induction of αv mRNA occurred...
Journal Articles
J Cell Sci (1994) 107 (3): 377–386.
Published: 1 March 1994
... generated by the myofibril are transduced laterally into the extracellular matrix. We observed costameres developing in cultured skeletal muscles, grown in micromass culture from cells taken from embryonic chicken leg. We detected proteins by immunofluorescence and mRNA by in situ hybridization. Antibody...
Journal Articles
J Cell Sci (1994) 107 (3): 353–366.
Published: 1 March 1994
... proteinase activity, seem to co-localize with the specific kind of cytoplasmic intermediate filament in relation to the cell type. These results, which generalize the previous data, are discussed in view of possible role(s) for prosomes in mRNA metabolism and/or intermediate filaments remodelling...
Journal Articles
J Cell Sci (1993) 104 (4): 1187–1197.
Published: 1 April 1993
...R. W. Dirks; F. M. van de Rijke; S. Fujishita; M. van der Ploeg; A. K. Raap ABSTRACT We have determined optimal conditions for the detection of mRNA sequences in cultured cells by non-radioactive in situ hybridization. For this purpose a number of different cell lines have been used: rat 9G cells...
Journal Articles
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 61–67.
Published: 1 February 1991
..., the mRNA that encodes the protein is also located in dendrites. This suggests that synthesis of MAP2 may be regulated locally in the dendritic cytoplasm. The molecular mechanism underlying the sorting of these proteins within neurons is unknown at present. © The Company of Biologists Limited 1991 1991...