... by adhesion molecules, is well established for mesenchymal cells such as fibroblasts, whereas its existence remains unreported for amoeboid cells that require less or no adhesion in order to migrate. We show that, in vitro , amoeboid human T lymphocytes develop adhesive haptotaxis mediated by densities...

...Tiphaine Douanne; Julie Gavard; Nicolas Bidère ABSTRACT Antigen-receptor-mediated activation of lymphocytes relies on a signalosome comprising CARMA1 (also known as CARD11), BCL10 and MALT1 (the CBM complex). The CBM activates nuclear factor κB (NF-κB) transcription factors by recruiting...

... Kaer L. , Kerr L. D. ( 2000 ). Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function . J. Immunol. 165 , 5418 - 5427 . Compagno M. , Lim W. K. , Grunn A. , Nandula S. V. , Brahmachary M. , Shen Q...

... ). HS1-deficient mice do not exhibit major defects in lymphocyte development, but immunoreceptor-induced proliferation of lymphocytes is impaired ( Gomez et al., 1997 ; Taniuchi et al., 1995 ). Studies in HS1-deficient T cells reveal that although TCR-stimulated tyrosine phosphorylation events...

... cells (Jurkat) were found to synthesize laminin α4, β1 and γ1 mRNAs and polypeptides and to assemble the chains into laminin-8. Lymphoblastoid B (NAD-20) cells, lymphoid NK (NKL) cells and blood lymphocytes also contained laminin-8 and, after cell permeabilization, practically all blood lymphocytes...

... ) 05 03 1993 15 07 1993 © 1997 by Company of Biologists 1997 Transferrin Receptor Lymphocyte Coated-pit independent endocytosis Cytoskeleton Ligands bound to specific receptors on the cell surface are internalized by receptor-mediated endocytosis. Once they have reached...

... in nuclei of Sertoli cells of the adult testis and in stimulated blood lymphocytes. The distribution of chromosomes in the two cell types is significantly different. A strong tendency for each pair of homologues to pair is inferred from the observation of only a single detectable signal in the majority...

... that the dissociation constant for erythrocytes was determined to be 8 µM and for lymphocytes to be almost 3 µM. On the basis of this comparison together with artificial membranes, the membrane protein components of the lym phocyte surface are implicated in the binding of albumin or the erythrocyte membrane proteins...

... event. However, in experiments using lymphocytes from heterozygous cattle in which at least four MHC class I gene products are expressed, mAbs which reacted with only one of these products did not inhibit entry. Using a series of bovine deletion mutant cell lines from which one or both MHC class I...

...Helen Hourihan; Terry D. Allen; Ann Ager ABSTRACT The constitutive recirculation of lymphocytes between the widely distributed organs of the immune system is essential for host defence. We have developed an in vitro model of lymphocyte migration from the blood into lymph nodes which employs primary...

..., the basis for the research being the relationship that has recently been shown to exist between the morphology of cell death and its pathogenesis. Chang liver cells coated with a rabbit anti-human antibody were used as targets and normal human peripheral-blood lymphocytes as effector cells. Cytotoxicity...