..., a chaperone for lysosomal enzyme targeting and a lipid transporter. The large luminal domain of LIMP-2 contains a hydrophobic tunnel that enables transport of phospholipids, sphingosine and cholesterol from the lysosomal lumen to the membrane. The question about the fate of the lipids after LIMP-2-mediated...

...: To study the intricate metabolic network of sphingolipids, minimally modified probes are the tools of choice. We review progress made by using these probes together with the power of click chemistry. Expansion microscopy Lipid metabolism Lipid transport Photoactivation Photocrosslinking...

... of the VPS13A–XK complex is the basis of both diseases. References Adlakha , J. , Hong , Z. , Li , P. Q. and Reinisch , K. M. (2022). Structural and biochemical insights into lipid transport by VPS13 proteins . J. Cell Biol. 221 , e202202030 . 10.1083/jcb.202202030 Bean...

... chlamydial inclusions, thereby promoting inclusion growth and bacterial development. Chlamydia trachomatis Rab Rab39a Multivesicular bodies Pathogen–host-cell interaction Lipid transport Infections caused by Chlamydia trachomatis have a substantial impact on public health. Recurring...

.... These effectors function in vesicle formation and tethering, non-vesicular lipid transport and cytoskeletal regulation. Beyond fundamental membrane trafficking roles, Arf proteins also regulate mitosis, plasma membrane signaling, cilary trafficking and lipid droplet function. Tight spatial and temporal regulation...

... glucosylceramide over the phospholipid sphingomyelin. Here, we have interfered with the integrity of the Golgi complex in various ways and tested the effects on lipid transport and sorting. Nocodazole, which depolymerizes microtubules, dispersed the Golgi over the cytoplasm of MDCK cells and reduced transport...