... promotes invasion and migration in multiple tumor types. The mechanisms by which LCN2 promotes invasion and migration remain unclear. Previous work from our laboratory demonstrated that LCN2 promotes actin filament formation by inhibiting actin glutathionylation. In this study, we demonstrate...

... to generate increased pressure in the back compartment that drives the nucleus through the constriction. Nucleus Confined migration Invasion Cortex Mechanobiology Pressure National Institutes of Health R01 HL082792 R01 CA 221346 U54 CA210184 R35 GM153257 R01 GM137605...

... and mammalian hosts. Motility and invasion are powered by an actin–myosin motor complex linked to the glideosome, which contains glideosome-associated proteins (GAPs), MyoA and the myosin A tail-interacting protein (MTIP). However, the role of several proteins involved in gliding motility remains unknown. We...

... mechanistic contributions of CA induction alone to tumour architecture and extracellular matrix (ECM) remodelling. CA induction in non-tumorigenic breast cells MCF10A causes cell migration and invasion, with underlying disruption of epithelial cell–cell junction integrity and dysregulation of expression...

... a helical path. The cortical microtubules, which are ultra-stable and spirally arranged, have been considered to be a structure that guides the long-distance movement of the parasite. Here, we address the role of the cortical microtubules in parasite motility, invasion and egress by utilizing a previously...

... promoted lamellipodia formation. We also demonstrate that SHARPIN S146 phosphorylation-mediated ARP2/3 interaction is sensitive to inhibition of ERK1/2 or reactivation of protein phosphatase 2A (PP2A). Notably, CRISPR/Cas9-mediated knockout of SHARPIN abrogated three-dimensional (3D) invasion of several...

... oligomers and key features of SRC signal encoding and decision-making activity. SRC Conformational intermediates Optogenetics Time-resolved phosphoproteomics Pleiotropy Migration Invasion Encoding intracellular signaling Cytoskeletal Adhesions Agence Nationale de la Recherche http...

...Afsheen Banisadr; Mariam Eick; Pranjali Beri; Alison D. Parisian; Benjamin Yeoman; Jesse K. Placone; Adam J. Engler; Frank Furnari ABSTRACT A lack of biological markers has limited our ability to identify the invasive cells responsible for glioblastoma multiforme (GBM). To become migratory...

...Battuya Bayarmagnai; Louisiane Perrin; Kamyar Esmaeili Pourfarhangi; Xavier Graña; Erkan Tüzel; Bojana Gligorijevic ABSTRACT The process of tumor cell invasion and metastasis includes assembly of invadopodia, protrusions capable of degrading the extracellular matrix (ECM). The effect of cell cycle...

... and structural inheritance over successive generations. This was correlated with a major invasion deficiency at early stages of CEN2 knockdown, and replication defects at later stages. These results indicate that CEN2 is incorporated into multiple cytoskeletal structures to serve distinct functions...

... as PTK2B), which initiates the SOCE–Pyk2–Src signaling cascade required for invasion. Overall, the discovery of elemental Ca 2+ signals of SOCE not only unveils a previously unappreciated gating mode of STIM1-Orai1 channels in situ , but also underscores a critical role of the spatiotemporal dynamics...

...Samer J. Hanna; Kessler McCoy-Simandle; Edison Leung; Alessandro Genna; John Condeelis; Dianne Cox ABSTRACT The interaction between tumor cells and macrophages is crucial in promoting tumor invasion and metastasis. In this study, we examined a novel mechanism of intercellular communication, namely...

... exacerbated in three-dimensional culture, where FGFR2 mutant cells were unable to form well-organised acini, instead undergoing exogenous ligand-independent invasion. Our findings uncover collective cell polarity and invasion as common targets of disease-associated FGFR2 mutations that lead to poor outcome...

.... , Beauchamp , E. M. , Rahim , S. , Kosturko , G. W. , Glasgow , E. , Dakshanamurthy , S. , Lee , H.-S. , Daar , I. , et al. (2012). Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells . Oncogene   31 , 269 - 281 . 10.1038/onc.2011.245...

... known as MAPK1) signalling to promote an invasive phenotype. However, the mechanisms through which Rab17 loss permits invasiveness, and the endosomal cargoes that are responsible for mediating this, are unknown. Using quantitative mass spectrometry-based proteomics, we have found that knockdown of Rab17...

...Tae-Hyung Kim; Navjot Kaur Gill; Kendra D. Nyberg; Angelyn V. Nguyen; Sophia V. Hohlbauch; Nicholas A. Geisse; Cameron J. Nowell; Erica K. Sloan; Amy C. Rowat ABSTRACT Invasion by cancer cells is a crucial step in metastasis. An oversimplified view in the literature is that cancer cells become more...

...: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs Spreading initiation centers SICs RNA-binding proteins Focal adhesion Translation regulation Invasion Mesenchymal cells...

... cell biology in vivo . Owing to the versatility of this workflow, we envision broad applications in various fields of biological research, such as cancer or developmental biology. Ultrastructural details of the two identified invasive cells (Fig. 7 A, arrows 1 and 3) were imaged by using serial TEM...

... remodelling of adhesions, through rapid endocytic and exocytic trafficking of integrin receptors, is an important mechanism employed by cells to regulate integrin–ECM interactions, and thus cellular signalling, during processes such as cell migration, invasion and cytokinesis. The initial concept of integrin...

... tethered at focal adhesion complexes, Eps8 is also recruited to focal adhesions and is required for FAK-dependent polarization and invasion. Therefore, Eps8 is a crucial mediator of Src- and FAK-regulated processes; it participates in specific biochemical complexes and promotes actin re-arrangements...