...Thomas D. Carroll; Alistair J. Langlands; James M. Osborne; Ian P. Newton; Paul L. Appleton; Inke Näthke ABSTRACT Homeostasis of renewing tissues requires balanced proliferation, differentiation and movement. This is particularly important in the intestinal epithelium where lineage tracing suggests...

... together, the data show that EGF suppresses cell shedding in the intestinal epithelium through a selective MAPK-dependent pathway affecting multiple extrusion mechanisms. EGFR signaling might be a therapeutic target for disorders featuring excessive cell turnover, such as inflammatory bowel diseases...

...Amelie Rezza; Seham Skah; Colette Roche; Julien Nadjar; Jacques Samarut; Michelina Plateroti The RNA-binding protein Musashi-1 (Msi1) has been proposed as a marker of intestinal epithelial stem cells. These cells are responsible for the continuous renewal of the intestinal epithelium. Although...

... ClC-2 Intestinal epithelium Epithelial polarity MDCK cells LLC-PK1 cells CBS domains Cystic fibrosis (CF) is an autosomal recessive disease that affects the epithelium of the gastrointestinal tract, sweat ducts, respiratory tract and the male reproductive system. The disease is caused...

... epithelial cells could modulate their cell-matrix signalling even while rapidly migrating in heterogeneous sheets over a shared basement membrane. *Author for correspondence (e-mail: [email protected] ) 14 3 2001 © The Company of Biologists Limited 2001 2001 Intestinal epithelium...

... analogue of prostaglandin I 2 ) and/or prostaglandin E 2 (1 μM) caused a significant reduction of reactive oxygen species-induced cell injury, mimicking the effect of trefoil factor 3. In summary, our results indicate that trefoil factor 3 activates cyclooxygenase-2 in intestinal epithelium to produce...

..., is predominantly expressed in the epithelial cells of several tissues. We demonstrate here that Munc-18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal epithelium and Caco-2 cells. The presence of a physical complex of the two proteins is verified by 2-way coimmunoprecipitation...

... membrane. * Author for correspondence 20 04 1994 21 06 1994 © 1994 by Company of Biologists 1994 membrane protein carcinoembryonic antigen dipeptidylpeptidase IV cell polarity intestinal epithelium cancer cell line The transepithelial transport and vectorial...

... mucosal immunity intestinal epithelium oral vaccines The lining of the intestine is a vast monolayer of highly polarized epithelial cells that provides an effective barrier to most of the macromolecules, microorganisms and toxins present in the intestinal lumen. One component of this barrier...

... intestinal epithelium morphogenesis mesenchyme organ culture The interaction between the epithelium and surrounding mesenchyme has been intensively studied by epithelial-mesenchymal recombination experiments. The results indicate that mesenchymes play major roles in determining epithelial...