...Leila S. Coelho-Rato; Sepideh Parvanian; Sarka Andrs Salajkova; Ohad Medalia; John E. Eriksson ABSTRACT Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular...

..., host cytoskeletal networks constantly interact with bacteria and are integral to their uptake. Vimentin, an intermediate filament protein, is one such cytoskeletal component that interacts with bacteria during infection. Although vimentin is predominantly present in the cytoplasm, it also appears...

...Sujin Kim; Younglan Lim; So-Young Lee; Han-Na Yoon; Hayan Yi; Kwi-Hoon Jang; Nam-On Ku ABSTRACT Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role...

...-causing mutation on nuclear structure. National Institutes of Health http://dx.doi.org/10.13039/100000002 R01AR04897 Nuclear lamins are the intermediate filament (IF) building blocks of the nuclear lamina on the nucleoplasmic aspect of the inner nuclear membrane of metazoan cells...

...Yue Zhang; Zeyu Wen; Xuemeng Shi; Yan-Jun Liu; John E. Eriksson; Yaming Jiu ABSTRACT Epidemics caused by viral infections pose a significant global threat. Cytoskeletal vimentin is a major intermediate filament (IF) protein, and is involved in numerous functions, including cell signaling...

...Sachiko Fujiwara; Shinji Deguchi; Thomas M. Magin ABSTRACT Keratin intermediate filament (IF) proteins constitute the major cytoskeletal components in epithelial cells. Missense mutations in keratin 5 (K5; also known as KRT5) or keratin 14 (K14; also known as KRT14), highly expressed in the basal...

..., which mediates the assembly of CTP synthase filaments along the cytokeratin network to modulate enzymatic activity. CTPS filaments Intermediate filaments SNAP29 Histidine Ministry of Science and Technology, Taiwan 10.13039/501100004663 108-2311-B-182-004-MY3 MOST 108-2321-B-182...

... sheets and developing organisms. However, these contractile networks do not work alone but in concert with other cytoarchitectural elements, including a diverse network of intermediate filaments. This Review takes a close look at the intermediate filament network and its associated intercellular...

...Roy A. Quinlan; Nicole Schwarz; Reinhard Windoffer; Christine Richardson; Tim Hawkins; Joshua A. Broussard; Kathleen J. Green; Rudolf E. Leube ABSTRACT Textbook images of keratin intermediate filament (IF) networks in epithelial cells and the functional compromization of the epidermis by keratin...

... filament organization and delays apoptosis, thereby protecting liver from injury. Keratin Intermediate filaments Liver Apoptosis Caspase Cell integrity Protein stability Ministry of Education, Science and Technology 10.13039/501100004085 2016R1A2B4012808 Keratin 8...

... at different levels. National Institutes of Health 10.13039/100000002 AR39617 European Commission 10.13039/501100000780 FP7/REGPOT-2008-1 Desmin, the muscle-specific intermediate filament protein, forms a three-dimensional scaffold that interconnects the contractile apparatus...

... the control of NF-κB signaling. This kinase is post-translationally regulated through Hsp70-mediated refolding. Previous work has shown that such a chaperoning activity is specifically localized to keratin intermediate filaments. Our work was performed with the goal of identifying the molecule(s) that block...

...Claire L. Hyder; Glorianne Lazaro; Joanna W. Pylvänäinen; Maxwell W. G. Roberts; Susanna M. Qvarnström; John E. Eriksson ABSTRACT Nestin, an intermediate filament protein and marker of undifferentiated cells, is expressed in several cancers. Nestin is important for neuronal survival...

.... It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IFBD). Mutations affecting the IFBD cause devastating human diseases. Here, we show that serine 4642, which is located in the extreme C-terminus...

... filaments and microtubules in cell motility is well established, the role of intermediate filaments in this process is incompletely understood. Organization and structure of the keratin cytoskeleton, which consists of heteropolymers of at least one type 1 and one type 2 intermediate filament, are in part...

...Lee Wallace; Leiann Roberts-Thompson; Julia Reichelt Keratins K1 and K10 are the most abundant proteins in the upper epidermis where they polymerize to form intermediate filaments (IFs). In addition to their well-established function in providing epidermal stability, K1/K10 (i.e. the dimer between...

...Gloria M. Conover; Carol C. Gregorio Desmin intermediate filaments intimately surround myofibrils in vertebrate muscle forming a mesh-like filament network. Desmin attaches to sarcomeres through its high-affinity association with nebulin, a giant F-actin binding protein that co-extends along...

...Ruben Postel; Mirjam Ketema; Ingrid Kuikman; José M. de Pereda; Arnoud Sonnenberg The outer nuclear membrane protein nesprin-3 binds the cytoskeletal linker protein plectin, which are proposed to anchor the intermediate filaments to the nuclear envelope. To investigate the function of nesprin-3...

...W. Thomas Clarke; Ben Edwards; Karl J. A. McCullagh; Matthew W. Kemp; Catherine Moorwood; Diane L. Sherman; Matthew Burgess; Kay E. Davies Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein...

... ) 25 8 2009 © The Company of Biologists Limited 2009 2009 Intermediate filaments Keratin 8 Keratin 18 Cytoprotection Mitochondria Liver injury Apoptosis Cytochrome c release Oxidative stress Intermediate filaments (IFs), actin-containing microfilaments and microtubules...