..., we show that IL-15 increases plasticity between cell migration behaviours and that different integrin ligands induce different forms of NK cell migration. * Author for correspondence ( [email protected] ) Handling Editor: Andrew Ewald Competing interests T.W.F.S. is the sole...

... on NPC fate of β1-integrin (ITGB1) and integrin-linked kinase signaling, and these effects are dependent on extracellular matrix cues. These findings demonstrate that TAZ and YAP perform divergent functions in the regulation of astrocyte differentiation, where YAP regulates cell cycle states...

... demonstrating how exposure of tumor cells to isolation stress upregulates the G-protein-coupled receptor lysophosphatidic acid receptor 4 (LPAR4), its downstream target fibronectin and two fibronectin-binding integrins, α5β1 and αvβ3. These responses create a fibronectin-rich niche for tumor cells, ultimately...

...: Mucinous colorectal carcinoma tumors maintain a robust apico-basolateral polarity with two distinct topologies – either a conventional ‘apical-in’ polarity or an inverted ‘apical-out’ topology. Apicobasolateral polarity Colorectal cancer Integrins Organoids TGFβ Institut National Du...

... wall. These events require the T cell integrins LFA-1 and VLA-4 and their endothelial ligands ICAM-1 and VCAM-1, respectively. T cells migrate against the direction of shear flow on ICAM-1 and with the direction of shear flow on VCAM-1, suggesting that these two ligands trigger distinct cellular...

... of integrin ligands expressed by high endothelial venules. Moreover, lymphocytes orient towards increasing adhesion with VLA-4 integrins (also known as integrin α 4 β 1 ), like all mesenchymal cells, but towards decreasing adhesion with LFA-1 integrins (also known as integrin α L β 4 ), which has...

... the presence of fibronectin on the sperm surface, its role in sperm–sperm interaction as well as participation of β-integrin in the activation of ERK2. Our results show that the signaling pathway downstream of fibronectin, via integrin, FAK, Grb2, MEK1/2, ERK2, GEF-H1 and RhoA regulates the actin...

... assays. We also illustrate how this system can be useful in a study as we investigated the behavior of integrin adhesion complexes upon cell stretching. We therefore present a cost-effective, multipurpose cell-stretching system that should help to increase understanding of mechanical signaling...

...Michael J. Shannon; Judith Pineau; Juliette Griffié; Jesse Aaron; Tamlyn Peel; David J. Williamson; Rose Zamoyska; Andrew P. Cope; Georgina H. Cornish; Dylan M. Owen; Ana-Maria Lennon-Duménil ABSTRACT Effector T-cells rely on integrins to drive adhesion and migration to facilitate their immune...

...Martinho Soto-Ribeiro; Birgit Kastberger; Michael Bachmann; Latifeh Azizi; Kenza Fouad; Marie-Claude Jacquier; David Boettiger; Daniel Bouvard; Martin Bastmeyer; Vesa P. Hytönen; Bernhard Wehrle-Haller ABSTRACT Heterodimeric integrin receptors control cell adhesion, migration and extracellular...

...Nicola De Franceschi; Mitro Miihkinen; Hellyeh Hamidi; Jonna Alanko; Anja Mai; Laura Picas; Camilo Guzmán; Daniel Lévy; Peter Mattjus; Benjamin T. Goult; Bruno Goud; Johanna Ivaska ABSTRACT Integrin transmembrane receptors control a wide range of biological interactions by triggering the assembly...

.... To identify adhesion receptor systems and matrix structures supporting glioma cell invasion into brain-like environments we used 2D and 3D organotypic invasion assays in combination with antibody-, peptide- and RNA-based interference. Combined interference with β1 and αV integrins abolished the migration of U...

...Cédric Zeltz; Donald Gullberg ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were originally identified on a subset of activated T-cells, and have since been found...

...Emanuel Rognoni; Raphael Ruppert; Reinhard Fässler ABSTRACT The kindlin (or fermitin) family of proteins comprises three members (kindlin-1,-2 and -3) of evolutionarily conserved focal adhesion (FA) proteins, whose best-known task is to increase integrin affinity for a ligand (also referred...

... knockdown, suggesting that nucleotide-dependent responses are not required for P2Y 2 R functions in tubular formation. The Arg-Gly-Asp (RGD) sequence of P2Y 2 R has been shown to interact with integrins, and a P2Y 2 R mutant lacking integrin-binding activity was unable to induce tubular formation. P2Y 2 R...

... the development of the follicle cell epithelium of the Drosophila ovary. Here, we have identified a fourth player, the integrin signaling pathway. Elimination of integrin function blocks the mitosis-to-endocycle switch and differentiation in posterior follicle cells (PFCs), by regulation of the cyclin-dependent...

...-like receptor (TLR) signaling in dendritic cells (DCs) suggests they have an important role in migration. Integrins are thought to participate in formation and dynamics of podosomes but the multiplicity of integrins in podosomes has made this difficult to assess. We report that murine DCs that lack β2...

... in the protein levels of integrin α5β1 at the cell membrane, activation of integrin β1 and an increase in integrin clustering. These effects have striking consequences for cell invasion, as nestin downregulation leads to a significant increase in pFAK- and integrin-dependent matrix degradation and cell invasion...

...Shomita S. Mathew; Bethsaida Nieves; Sharon Sequeira; Savitha Sambandamoorthy; Kevin Pumiglia; Melinda Larsen; Susan E. LaFlamme ABSTRACT Cytokinesis is the final stage in cell division. Although integrins can regulate cytokinesis, the mechanisms involved are not fully understood. In this study, we...

... macrophage migration in vivo . Integrins are key regulators of many of the adult macrophage responses, but their role in embryonic macrophages remains poorly characterized. Here, we have used Drosophila macrophages (haemocytes) as a model system to address the role of integrins during embryonic macrophage...