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Keywords: hsp70
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Journal Articles
In collection:
Proteostasis
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (11): jcs261977.
Published: 12 June 2024
...×GFP-op had higher cytotoxicity than 3×MOX-op because it perturbed the ubiquitin-proteasome system. Static aggregates formed by 3×GFP-op dynamically trapped Hsp70 family proteins (Ssa1 and Ssa2 in yeast), causing the heat-shock response. Systematic analysis of mutants deficient in the protein quality...
Includes: Supplementary data
Journal Articles
In collection:
Nuclear structure and function
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
.... However, the molecular mechanisms that regulate nuclear structure–function relationships during heat shock remain unclear. Here, we show that lamin A and C (hereafter lamin A/C; both lamin A and C are encoded by LMNA ) are required for heat-shock-mediated transcriptional induction of the Hsp70 gene locus...
Includes: Supplementary data
Journal Articles
Sara Sannino, Christopher J. Guerriero, Amit J. Sabnis, Donna Beer Stolz, Callen T. Wallace, Peter Wipf, Simon C. Watkins, Trever G. Bivona, Jeffrey L. Brodsky
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (17): jcs217760.
Published: 5 September 2018
... and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family proteins (hereafter Hsp70) in rhabdomyosarcoma triggers UPR induction and apoptosis. To define how these cancer cells...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (6): jcs210948.
Published: 20 March 2018
...Ganapathi Kandasamy; Claes Andréasson ABSTRACT During protein quality control, proteotoxic misfolded proteins are recognized by molecular chaperones, ubiquitylated by dedicated quality control ligases and delivered to the 26S proteasome for degradation. Proteins belonging to the Hsp70 chaperone...
Includes: Supplementary data
Journal Articles
Lavanya Ramapathiran, Tytus Bernas, Franziska Walter, Linda Williams, Heiko Düssmann, Caoimhín G. Concannon, Jochen H. M. Prehn
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (3): 609–619.
Published: 1 February 2014
... inhibition, relative to apoptosis activation in HCT116 colon cancer cells expressing enhanced green fluorescent protein (EGFP) under the control of the HSP70 promoter. Single-cell and high-content time-lapse imaging of epoxomicin treatment revealed that neither basal activity nor the time of onset of the HSR...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (14): 2367–2374.
Published: 15 July 2011
... chaperone protein HSP70 can prevent stress-induced cell death by inhibiting signaling pathways that lead to apoptosis. In this study, we used high-resolution two-dimensional gel electrophoresis and phosphoprotein staining to identify signaling pathways that are altered by hyperthermia and modulated by HSP70...
Journal Articles
Chaoqian Xu, Yanjie Lu, Zhenwei Pan, Wenfeng Chu, Xiaobin Luo, Huixian Lin, Jiening Xiao, Hongli Shan, Zhiguo Wang, Baofeng Yang
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (17): 3045–3052.
Published: 1 September 2007
...-1 level was significantly increased in response to oxidative stress. We identified single target sites for miR-1 only, in the 3′-untranslated regions of the HSP60 and HSP70 genes, and multiple putative target sites for miR-133 throughout the sequence of the caspase-9 gene. miR-1 reduced the levels...
Includes: Supplementary data
Journal Articles
Xian-Chun Zeng, Samir Bhasin, Xufeng Wu, Joeng-Goo Lee, Shivani Maffi, Christopher J. Nichols, Kyung Jin Lee, J. Paul Taylor, Lois E. Greene, Evan Eisenberg
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (21): 4991–5000.
Published: 1 October 2004
...Xian-Chun Zeng; Samir Bhasin; Xufeng Wu; Joeng-Goo Lee; Shivani Maffi; Christopher J. Nichols; Kyung Jin Lee; J. Paul Taylor; Lois E. Greene; Evan Eisenberg The molecular chaperone Hsp70 interacts with misfolded proteins and also accumulates in the nucleus during heat shock. Using GFP-Hsp70...
Journal Articles
Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (5): 701–710.
Published: 15 February 2004
...Victoria M. Longshaw; J. Paul Chapple; Maria S. Balda; Michael E. Cheetham; Gregory L. Blatch The co-chaperone murine stress-inducible protein 1 (mSTI1), an Hsp70/Hsp90 organizing protein (Hop) homologue, mediates the assembly of the Hsp70/Hsp90 chaperone heterocomplex. The mSTI1 protein can...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (17): 3557–3570.
Published: 1 September 2003
... component of the stress granules. Based on analysis of our deletion mutants, HSF2 influences to the localization of HSF1 in stress granules. Moreover, our results indicate that the stress granules are dynamic structures and suggest that they might be regulated in an Hsp70-dependent manner. The reversible...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (14): 2809–2816.
Published: 15 July 2002
... function of signal transduction pathways. The relative levels of these proteins may be important, as too little or too much Hsp70 or Hsp90 can result in aberrant growth control, developmental malformations and cell death. Although the functions of heat shock proteins as molecular chaperones have been well...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (12): 2517–2527.
Published: 15 June 2002
... was found between an N-terminal region of HSV UL14 protein and the substrate-binding domain of Hsp70 family proteins. Two arginine residues in this region were important for nuclear translocation of VP26. In addition, overexpression of UL14 protein increased the activity of coexpressed firefly luciferase...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (19): 3565–3574.
Published: 1 October 2001
...Akemi Kawai; Shuh-ichi Nishikawa; Aiko Hirata; Toshiya Endo Ssc1p, a member of the Hsp70 family in the mitochondrial matrix of budding yeast, mediates protein import into mitochondria and prevents irreversible aggregation of proteins in the mitochondrial matrix during folding/assembly...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (10): 1839–1845.
Published: 15 May 2001
...Yilmaz Niyaz; Matthias Zeiner; Ulrich Gehring ABSTRACT We investigated human Hap50, the large isoform of the previously characterized Hsp70/Hsc70-associating protein Hap46, also called BAG-1, for effects on transcriptional activities. Overproduction by transient transfection led to enhanced...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (13): 2091–2098.
Published: 1 July 1999
... mutants, P574H accumulated in punctate cytoplasmic bodies that colocalized with endoplasmic reticulum (ER) markers. At 26°C, these bodies were no longer present. P574H showed a prolonged association with Hsp70 and also colocalized with Hsp70. We used brefeldin A (BFA) to determine which processing step(s...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (11): 3541–3545.
Published: 1 November 1995
...Melissa A. Bloch; Karl A. Johnson ABSTRACT Monoclonal antibodies that recognize HSP70 family members from evolutionarily divergent organisms were used to identify both constitutively-expressed and stress-inducible HSP70 proteins in the green alga Chlamy-domonas . These monoclonal antibodies also...
Journal Articles
Nuria E. Vilaboa, Consuelo Calle, Concepción Pérez, Elena de Blas, Laura García-Bermejo, Patricio Aller
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (8): 2877–2883.
Published: 1 August 1995
...Nuria E. Vilaboa; Consuelo Calle; Concepción Pérez; Elena de Blas; Laura García-Bermejo; Patricio Aller ABSTRACT Treatment of U-937 human promonocytic cells with the cAMP increasing agents isoproterenol plus theophylline decreased the basal level of heat-shock protein 70 ( HSP70 ) mRNA. In addition...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (3): 1295–1306.
Published: 1 March 1995
... required to target and fuse with its acceptor membrane ( Palade, 1975 ). Prior to fusion with the acceptor organelle the protein coat is removed. hsp70 clathrin-coated vesicles ATPase coatomer © 1995 by Company of Biologists 1995 05 07 1994 05 07 1994 * Author...
Journal Articles
Eric Perret, Mohammed Moudjou, Marie Line Geraud, Jean Derancourt, Marie-Odile Soyer-Gobillard, Michel Bornens
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (2): 711–725.
Published: 1 February 1995
... or associated structures in several systems, including unicellular eukaryotes such as dinoflagellates or ciliates. A 72 kDa antigen has been identified and purified from the dinoflagellate C. cohnii and its NH 2 -terminal sequence partially established. It shows a close homology with HSP70 proteins...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 105 (4): 1115–1120.
Published: 1 August 1993
... by Company of Biologists 1993 hsp70 glycosylation cytokinesis The luminal compartment of the endoplasmic reticulum (ER) contains a subset of proteins that are soluble but nevertheless are not secreted by vesicle transport out of the cell. One member of this group is BiP, a protein...
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