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Keywords: hsp70
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Journal Articles
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Proteostasis
J Cell Sci (2024) 137 (11): jcs261977.
Published: 12 June 2024
...×GFP-op had higher cytotoxicity than 3×MOX-op because it perturbed the ubiquitin-proteasome system. Static aggregates formed by 3×GFP-op dynamically trapped Hsp70 family proteins (Ssa1 and Ssa2 in yeast), causing the heat-shock response. Systematic analysis of mutants deficient in the protein quality...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
.... However, the molecular mechanisms that regulate nuclear structure–function relationships during heat shock remain unclear. Here, we show that lamin A and C (hereafter lamin A/C; both lamin A and C are encoded by LMNA ) are required for heat-shock-mediated transcriptional induction of the Hsp70 gene locus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217760.
Published: 5 September 2018
... and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family proteins (hereafter Hsp70) in rhabdomyosarcoma triggers UPR induction and apoptosis. To define how these cancer cells...
Includes: Supplementary data
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J Cell Sci (2004) 117 (21): 4991–5000.
Published: 1 October 2004
...Xian-Chun Zeng; Samir Bhasin; Xufeng Wu; Joeng-Goo Lee; Shivani Maffi; Christopher J. Nichols; Kyung Jin Lee; J. Paul Taylor; Lois E. Greene; Evan Eisenberg The molecular chaperone Hsp70 interacts with misfolded proteins and also accumulates in the nucleus during heat shock. Using GFP-Hsp70...
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J Cell Sci (2002) 115 (14): 2809–2816.
Published: 15 July 2002
... function of signal transduction pathways. The relative levels of these proteins may be important, as too little or too much Hsp70 or Hsp90 can result in aberrant growth control, developmental malformations and cell death. Although the functions of heat shock proteins as molecular chaperones have been well...
Journal Articles
J Cell Sci (2002) 115 (12): 2517–2527.
Published: 15 June 2002
... was found between an N-terminal region of HSV UL14 protein and the substrate-binding domain of Hsp70 family proteins. Two arginine residues in this region were important for nuclear translocation of VP26. In addition, overexpression of UL14 protein increased the activity of coexpressed firefly luciferase...
Journal Articles
J Cell Sci (2001) 114 (19): 3565–3574.
Published: 1 October 2001
...Akemi Kawai; Shuh-ichi Nishikawa; Aiko Hirata; Toshiya Endo Ssc1p, a member of the Hsp70 family in the mitochondrial matrix of budding yeast, mediates protein import into mitochondria and prevents irreversible aggregation of proteins in the mitochondrial matrix during folding/assembly...
Journal Articles
J Cell Sci (2001) 114 (10): 1839–1845.
Published: 15 May 2001
...Yilmaz Niyaz; Matthias Zeiner; Ulrich Gehring ABSTRACT We investigated human Hap50, the large isoform of the previously characterized Hsp70/Hsc70-associating protein Hap46, also called BAG-1, for effects on transcriptional activities. Overproduction by transient transfection led to enhanced...
Journal Articles
J Cell Sci (1999) 112 (13): 2091–2098.
Published: 1 July 1999
... mutants, P574H accumulated in punctate cytoplasmic bodies that colocalized with endoplasmic reticulum (ER) markers. At 26°C, these bodies were no longer present. P574H showed a prolonged association with Hsp70 and also colocalized with Hsp70. We used brefeldin A (BFA) to determine which processing step(s...
Journal Articles
J Cell Sci (1995) 108 (11): 3541–3545.
Published: 1 November 1995
...Melissa A. Bloch; Karl A. Johnson ABSTRACT Monoclonal antibodies that recognize HSP70 family members from evolutionarily divergent organisms were used to identify both constitutively-expressed and stress-inducible HSP70 proteins in the green alga Chlamy-domonas . These monoclonal antibodies also...
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Journal Articles
J Cell Sci (1995) 108 (3): 1295–1306.
Published: 1 March 1995
... required to target and fuse with its acceptor membrane ( Palade, 1975 ). Prior to fusion with the acceptor organelle the protein coat is removed. hsp70 clathrin-coated vesicles ATPase coatomer © 1995 by Company of Biologists 1995 05 07 1994 05 07 1994 * Author...
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Journal Articles
J Cell Sci (1993) 105 (4): 1115–1120.
Published: 1 August 1993
... by Company of Biologists 1993 hsp70 glycosylation cytokinesis The luminal compartment of the endoplasmic reticulum (ER) contains a subset of proteins that are soluble but nevertheless are not secreted by vesicle transport out of the cell. One member of this group is BiP, a protein...