...+ Endoplasmic reticulum HeLa cell Histamine IP 3 receptor KRAP MCU Membrane contact site Mitochondria Proximity ligation assay VDAC1 Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/TO/12986/1 Wellcome http://dx.doi.org/10.13039...

..., we demonstrate that the cAMP-dependent acid secretory agonist, histamine, induces a rapid, sustained rise in parietal cell lasp-1 phosphorylation and this increase in phosphorylation is closely correlated with the acid secretory response. In addition, elevation of intracellular cAMP concentrations...

... to a maximum of 835±195 nM, histamine (10 μM) to 352±51 nM, and ATP (5-500 μM) to more than 1500 nM. Nine of 14 cultures also responded to isoproterenol (10 μM), though with a smaller increase, to 210±29 nM. A response was observed with isoproterenol, and epinephrine, but not norepinephrine, phenylephrine...

...Taichi Takeda; Yuko Yamashita; Syuji Shimazaki; Youji Mitsui ABSTRACT To determine if histamine acts directly on the vascular endothelium, the effect of histamine on the permeability of cultured human endothelial cell monolayers and the role of second messengers were examined. The addition of 10 −6...