...Collin Y. Ewald; Alexander Nyström ABSTRACT Hemidesmosomes are structural protein complexes localized at the interface of tissues with high mechanical demand and shear forces. Beyond tissue anchoring, hemidesmosomes have emerged as force-modulating structures important for translating mechanical...

...Lisa te Molder; Jose M. de Pereda; Arnoud Sonnenberg ABSTRACT Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes...

... that periodically organized subcellular structures perform synchronized duplication to increase their numbers and accommodate epidermal cell growth. C. elegans Epidermis Periodic pattern Hemidesmosome Collagen National Natural Science Foundation of China 10.13039/501100001809 31670912...

.... In this study, we investigated the role of CD151 in the formation and maintenance of laminin-associated adhesions. We show that CD151, through binding to integrin α3β1, plays a critical role in the stabilization of an adhesion structure with a distinct molecular composition of hemidesmosomes with tetraspanin...

...Rong Fu; Yi Zhu; Xiaowan Jiang; Yuanbao Li; Ming Zhu; Mengqiu Dong; Zhaohui Huang; Chunxia Wang; Michel Labouesse; Huimin Zhang ABSTRACT Hemidesmosomes are epithelial-specific attachment structures that maintain tissue integrity and resist tension. Despite their importance, how hemidesmosomes...

...Leila Nahidiazar; Maaike Kreft; Bram van den Broek; Pablo Secades; Erik M. M. Manders; Arnoud Sonnenberg; Kees Jalink ABSTRACT Hemidesmosomes have been extensively studied with immunofluorescence microscopy, but owing to its limited resolution, the precise organization of hemidesmosomes remains...

...Emilie Faure; Françoise Garrouste; Fabrice Parat; Sylvie Monferran; Ludovic Leloup; Gilbert Pommier; Hervé Kovacic; Maxime Lehmann Summary α6β4 integrin is the main component of hemidesmosomes (HD) that stably anchor the epithelium to the underlying basement membrane. Epithelial cell migration...

...Karine Raymond; Maaike Kreft; Hans Janssen; Jero Calafat; Arnoud Sonnenberg The α6β4 integrin is located at the basal surface of keratinocytes, in hemidesmosomal structures that mediate stable adhesion of epidermal cells to the underlying basement membrane component laminin-5. The absence of α6β4...

...Jan Koster; Dirk Geerts; Bertrand Favre; Luca Borradori; Arnoud Sonnenberg Hemidesmosomes (HDs) are multi-protein complexes that promote stable adhesion of epithelial cells to the underlying extracellular matrix. We assessed the interactions between different hemidesmosomal components with each...

...Mirjam G. Nievers; Ingrid Kuikman; Dirk Geerts; Irene M. Leigh; Arnoud Sonnenberg ABSTRACT Hemidesmosomes are adhesion structures that mediate anchorage of epithelial cells to the underlying basement membrane. We have previously shown that the α6β4 integrin can induce the assembly of these multi...

... to a protein complex that can trigger the formation of hemidesmosomes, certain cell-matrix attachment sites found in epithelial cells. We have prepared a monoclonal antibody (12C4) whose epitope is located toward the carboxy terminus of the globular domain of the α3 laminin subunit. This epitope is lost from...

... segment, is critical for the localization of α 6 β 4 in hemidesmosomes. In addition, this region was shown to regulate the distribution of HD1/plectin in transfected cells. In order to investigate the function of the β 4 extracellular and cytoplasmic domains in the assembly and integrity of hemidesmosomes...

...Carien M. Niessen; Esther H. M. Hulsman; Lauran C. J. M. Oomen; I. Kuikman; Arnoud Sonnenberg ABSTRACT The integrin α6β4 is a major component of hemidesmosomes, in which it mediates firm adhesion to laminin 5. Previous studies have shown that the incorporation of α6β4 into hemidesmosomes requires...

...Paloma Sánchez-Aparicio; Ana M. Martínez de Velasco; Carien M. Niessen; Luca Borradori; Ingrid Kuikman; Esther H. M. Hulsman; Reinhard Fässler; Katsushi Owaribe; Arnoud Sonnenberg ABSTRACT The high molecular mass protein, HD1, is a structural protein present in hemidesmosomes as well as in distinct...

...Stephanie Stahl; Sigmund Weitzman; Jonathan C. R. Jones ABSTRACT In vivo, normal mammary epithelial cells utilize hemidesmosome attachment devices to adhere to stroma. However, analyses of a potential role for hemidesmosomes and their components in mammary epithelial tissue morphogenesis have never...

...Filippo G. Giancotti © 1996 by Company of Biologists 1996 α 6 β 4 integrin Hemidesmosome Signaling Fig. 1. Molecular architecture of the hemidesmosome. Fig. 2. Model of α 6 β 4 -mediated signal transduction. REFERENCES Aberdam , D...

...A. Sonnenberg; A. A. de Melker; A. M. Martinez de Velasco; H. Janssen; J. Calafat; C. M. Niessen ABSTRACT Keratinocytes attach to an underlying basement mem-brane by adhesion junctions called hemidesmosomes. We have characterized a cell line, RAC-11P/SD, estab-lished from a murine mammary tumor...

...Robert Edward Lee; Paul Kugrens ABSTRACT Katablepharis ovalis Skuja is a free-living unicellular flagellate with a phagocytic mode of nutrition. Each cell has one or two hemidesmosome-like attachment strips consisting of electron-dense ridges that pass through the plasma membrane to end...