... within the epidermal lineage; and orient hair follicles. We also describe how altered polarity signaling contributes to skin cancer. Fig. 4. Symmetric and asymmetric divisions in different compartments of the epidermis. In addition to ACD occurring in the IFE (see Fig. 2B), ACD-like divisions...

... and hair follicles. Previously, Rac1 was shown to regulate stem cell behaviour in these compartments. We have asked whether Rac1 has, in addition, a specific, stem-cell-independent function in the regulation of terminal hair follicle differentiation. To address this, we have expressed a constitutively...

...Anne-Catherine Feutz; Yann Barrandon; Denis Monard In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent...

...Uffe Birk Jensen; Xiaohong Yan; Charlotte Triel; Seung-Hyun Woo; Rikke Christensen; David M. Owens The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent capacity; however, the restricted contributions of these cells under homeostatic conditions indicates...

... keratinocytes of the interfollicular epidermis and in hair follicles. Here we have conditionally knocked out the POZ/BTB transactivation domain of Miz1 in keratinocytes using a keratin 14 (K14)- Cre mouse deleter strain. K14Cre + / Miz1 lox/lox mice have rough fur as a result of altered hair follicle...

... growth stimulation. * Author for correspondence (e-mail: [email protected]) 5 5 2005 © The Company of Biologists Limited 2005 2005 Cathepsins Epidermis Hair follicle Lysosomes Mice Knockout The molecular processes controlling proliferation...

...Majlinda Lako; Lyle Armstrong; Paul M. Cairns; Sue Harris; Nicholas Hole; Colin A. B. Jahoda Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental...

...Andrei A. Panteleyev; Colin A. B. Jahoda; Angela M. Christiano Recent genetic and molecular studies of hair follicle (HF) biology have provided substantial insight; however, the molecular data, including expression patterns, cannot be properly appreciated without an understanding of the basic...

...Karima Djabali; Vincent M. Aita; Angela M. Christiano ABSTRACT Hair follicle cycling is an exquisitely regulated and dynamic process consisting of phases of growth, regression and quiescence. The transitions between the phases are governed by a growing number of regulatory proteins, including...

... human α subunit (A,B) or γ subunit (C,D). The staining was largely attenuated by coincubation with the respective immunizing peptides (B,D). Bar, 83 µm. It has been previously reported that ENaC subunit mRNAs are expressed in rat epidermis and hair follicles (Roudier-Pujol et al., 1996). However...

... whereas the NF1-like proteins bound closer to the transcription start site. We conclude that the LEF-1 binding site is an enhancer element of the K2 . 10 promoter in the hair follicle cortex and that factors other than LEF-1 regulate promoter tissue- and differentiation-specificity. Fig. 4. LEF-1...

...Stephen Lyle; Melpo Christofidou-Solomidou; Yaping Liu; David E. Elder; Steven Albelda; George Cotsarelis ABSTRACT Stem cells are vital for the homeostasis of self-renewing tissues such as the hair follicle. Epithelial stem cells have been implicated in tumorigenesis and wound healing...

...-cell adhesion and signalling, is highly expressed in keratinocytes located in the bulge area of the rat vibrissa which contains the most K-CFCs. CD24 is also expressed in the outer epithelial sheath of human hair follicles and in glabrous epidermis. However, its expression is not restricted to K-CFCs...

... keratinocytes. * Author for correspondence 22 03 1995 12 11 1995 © 1996 by Company of Biologists 1996 In situ hybridization RNase protection Sweat gland Hair follicle Epidermis The entry and the transport of sodium in tight epithelia, namely the renal collecting duct...

...Da-Wen Yu; Tian Yang; Tadashige Sonoda; Kevin Gaffney; Pamela J. Jensen; Tom Dooley; Steve Ledbetter; Irwin M. Freedberg; Robert Lavker; Tung-Tien Sun ABSTRACT A group of specialized mesenchymal cells located at the root of the mammalian hair follicle, known as the follicu-lar or dermal papillary...

... an immortalised mouse hair follicle cortical cell line for the study of hair keratin gene control, SV40 TAg expression was targeted to the hair follicles of transgenic mice using a sheep hair gene promoter. Expression of SV40 TAg in the follicle cortex disrupted normal fiber ultra-structure, producing a marked...

... of Washington, Seattle, WA 98195, USA 11 10 1992 07 04 1993 © 1993 by Company of Biologists 1993 FGF hair follicle development The fibroblast growth factor (FGF) family is composed of a number of heparin-binding proteins characterized by their potent mitogenic effects...

...Colin A. B. Jahoda; Amanda J. Reynolds; Christine Chaponnier; James C. Forester; Giulio Gabbiani ABSTRACT We have examined the expression of smooth muscle α-actin in hair follicles in situ , and in hair follicle dermal cells in culture by means of immunohistochemistry. Smooth muscle "-actin...

...Amanda J. Reynolds; Colin A. B. Jahoda ABSTRACT Germinative epidermal cells in the lower end bulb region of anagen hair follicles are highly active, and give rise to hair fibres through rapid proliferation and complex differentiation. They have often been termed hair follicle stem cells, but owing...