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Keywords: growth factors
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Journal Articles
J Cell Sci (2007) 120 (20): 3688–3699.
Published: 15 October 2007
... Limited 2007 2007 Cell motility Cell proliferation Metalloproteases Transactivation Growth factors The EGF receptor (EGFR, also known as erbB1 and HER1) tyrosine kinase system is vitally involved in normal physiological processes such as tissue morphogenesis and wound repair, because...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (1): 172–183.
Published: 1 January 2006
..., or with the growth factors, IGF-1 or BDNF, increases SIRPα phosphorylation and SHP-2 binding rapidly and transiently, via Src family kinase activation; phosphorylated SIRPα dissociates from the lipid microdomains. A cytoplasmic tail fragment of SIRPα (cSIRPα), when expressed in primary cortical neurons, also...
Journal Articles
J Cell Sci (2004) 117 (15): 3189–3199.
Published: 1 July 2004
...Eugene Tkachenko; Esther Lutgens; Radu-Virgil Stan; Michael Simons Full activity of fibroblast growth factors (FGFs) requires their internalization in addition to the interaction with cell surface receptors. Recent studies have suggested that the transmembrane proteoglycan syndecan-4 functions...
Journal Articles
J Cell Sci (2002) 115 (9): 1961–1971.
Published: 1 May 2002
... of endogenous UPA in mediating the mitogenic effects of platelet-derived growth factor (PDGF) and basic fibroblast growth factor(bFGF) on human vascular smooth muscle cells (SMC). Growth-arrested SMC constitutively expressed UPA, but UPA expression and secretion increased several times upon stimulation...
Journal Articles
J Cell Sci (2001) 114 (19): 3433–3443.
Published: 1 October 2001
...-stimulated cells, there is a constant active export of p42/p44 MAPKs from the nucleus. We previously showed that removal of growth factors leads to the exit of p42/p44 MAPKs from the nucleus ( Lenormand et al., 1993 ). We thus tested the effect of a rapid and total block of MEK activity by UO126...
Journal Articles
J Cell Sci (1990) 1990 (Supplement_13): 31–42.
Published: 1 January 1990
...WILLIAM J. LAROCHELLE; NEILL GIESE; MARY MAY-SIROFF; KEITH C. ROBBINS; STUART A. AARONSON Summary Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprising two related chains encoded by distinct genes. The B chain is the homolog of the v- sis oncogene product...
Journal Articles
J Cell Sci (1990) 1990 (Supplement_13): 75–85.
Published: 1 January 1990
.... The expression of DIA/LIF in vitro is both developmentally programmed and controlled by the action of other growth factors, the most notable of which are members of the fibroblast growth factor family expressed by the stem cells themselves. This indicates that differentiation and proliferation in early...
Journal Articles
J Cell Sci (1988) 1988 (Supplement_10): 257–266.
Published: 1 February 1988
... and embryonic stem (ES) cells. EC cells have proved to be a useful source of embryonic growth factors. A potent mitogen, ECDGF has been isolated from EC cell conditioned medium. ECDGF appears to be a novel member of the heparin binding growth factor family. A remarkable feature of heparin binding growth factors...
Journal Articles
J Cell Sci (1988) 1988 (Supplement_10): 243–255.
Published: 1 February 1988
...WILLIAM L. FARRAR; STUART W. EVANS; ANNICK HAREL-BELLAN; DOUGLAS K. FERRIS Summary Haemopoietic growth factors stimulate a number of consensus biochemical and molecular events regardless of the specificity detailed by unique ligand and receptor structures. Analysis of three distinct colony...
Journal Articles
J Cell Sci (1988) 1988 (Supplement_10): 195–230.
Published: 1 February 1988
... . Signalling involves a bifurcating action of a combination of soluble growth factors e.g. TGF- α , TGF- β , PDGF and FGF on palatal epithelia and mesenchyme. These factors stimulate the synthesis of specific extracellular matrix molecules by palate mesenchyme cells, and the appearance of receptors...