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Keywords: growth factor
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Journal Articles
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Imaging
J Cell Sci (2016) 129 (18): 3485–3498.
Published: 15 September 2016
... to hyperpolarizing during development. Here, we introduce transforming growth factor β2 (TGF-β2) as a new regulator of KCC2 membrane trafficking and functional activation. TGF-β2 controls membrane trafficking, surface expression and activity of KCC2 in developing and mature mouse primary hippocampal neurons...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4856–4861.
Published: 01 November 2013
... barely understood. Here we show that, on the basis of its binding characteristics, the secreted ectodomain of APP (sAPP) is a new member of the heparin-binding growth factor superfamily. Like other of its members, sAPP binds in a bivalent manner to the plasma membrane with two different subdomains. The N...
Journal Articles
J Cell Sci (2013) 126 (14): 2979–2989.
Published: 15 July 2013
... for matrix degradation and are formed by cancer and normal cells, respectively. Although initial studies focused on defining the core machinery of these two structures, recent studies have identified inputs from both growth factor and adhesion signaling as crucial for invasive activity. This Commentary...
Journal Articles
J Cell Sci (2013) 126 (3): 745–755.
Published: 01 February 2013
...Maiko Higuchi; Rina Kihara; Tomohiko Okazaki; Ichiro Aoki; Shiro Suetsugu; Yukiko Gotoh Summary The crosstalk between spatial adhesion signals and temporal soluble signals is key in regulating cellular responses such as cell migration. Here we show that soluble growth factors enhance integrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3445–3458.
Published: 15 October 2008
..., the transferrin (Tf) receptor quantitatively recycles to the plasma membrane, whereas the epidermal growth factor (EGF) receptor undergoes degradation. To determine how Tf and EGF engage these two different pathways we imaged their binding and early endocytic pathway in live cells using total internal reflection...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (12): 2008–2017.
Published: 15 June 2008
... in the platelet-derived growth factor (PDGF)-induced activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling for cell survival. This complex was associated with PDGF receptor on the plasma membrane at cell-cell adhesion sites. Thus, the nectin-afadin complex is involved in PDGF-induced cell survival...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (14): 2997–3002.
Published: 15 July 2005
... ). Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 18 , 664 -674. Chang, L. and Karin, M. ( 2001 ). Mammalian MAP kinase signalling cascades. Nature 410 , 37 -40. Christen, B. and Slack, J...
Journal Articles
J Cell Sci (2004) 117 (22): 5405–5415.
Published: 15 October 2004
...Hisako Muramatsu; Peng Zou; Hiromichi Suzuki; Yoshihiro Oda; Guo-Yun Chen; Nahoko Sakaguchi; Sadatoshi Sakuma; Nobuaki Maeda; Masaharu Noda; Yoshikazu Takada; Takashi Muramatsu Midkine is a heparin-binding growth factor that promotes the growth, survival, migration and differentiation of various...
Journal Articles
J Cell Sci (2002) 115 (6): 1305–1312.
Published: 15 March 2002
... transforming growth factor-beta 1 (TGF-β1), which is known to control proliferation in epithelial cells, we now demonstrate that in the human HaCaT skin keratinocytes, TGF-β1 downregulated c-Myc, and this blocked proliferation. This also caused a decrease in hTERT expression, which in turn inhibited telomerase...
Journal Articles
J Cell Sci (2001) 114 (16): 2943–2951.
Published: 15 August 2001
... of polyploidy for understanding tissue development, regeneration and oncogenesis. 3 5 2001 © The Company of Biologists Limited 2001 2001 Growth factor Hepatocyte Liver Ploidy Regeneration Polyploid cells accumulate large amounts of DNA compared with diploid cells, due to DNA...
Journal Articles
J Cell Sci (1994) 107 (4): 747–752.
Published: 01 April 1994
... of ras. Proc. Nat. Acad. Sci. USA 89 , 6511 – 6515 Buday L. , Downward J. ( 1993 ). Epidermal growth factor regulates p21rasthrough the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73 , 611 – 620 Cantley L. C...
Journal Articles
J Cell Sci (1990) 1990 (Supplement_13): 97–117.
Published: 01 January 1990
...REINER WESTERMANN; CLAUDIA GROTHE; KLAUS UNSICKER Summary Basic fibroblast growth factor (bFGF), a heparin-binding mitogen for mesoderm-derived cells, also acts as a mitogen, differentiation inducing and maintenance factor for many neuroectodermal cells including glial cells, neurons, paraneurons...
Journal Articles
J Cell Sci (1990) 1990 (Supplement_13): 87–96.
Published: 01 January 1990
.... Sequence analysis showed int -2 to be a member of the fibroblast growth factor family of genes. In normal breast and most other adult mouse tissues, int -2 expression was not detected except for low levels in brain and testis. However, using in situ hybridization, expression was found at a number of sites...