... be responsible for downstream AP-1 activation ( Fig. 5B,C ). Interestingly, JunD is also known to be involved in connexin 43 ( GJA1 ) gene expression ( Mitchell and Lye, 2005 ) and has been demonstrated to be able to bind within the gene body of GJA1 as demonstrated by H1 ESC ENCODE CHIP data ( Fig. 5D...

... complex is dismantled is essential for appreciating how physiological gene expression is maintained and also how concurrent processes that occur synchronously on the DNA are coordinated. Although the strategies employed by the different classes of eukaryotic RNAPs are traditionally considered...

...) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/β-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of β-catenin target gene expression. Upon Wnt...

... binding to the TSS of genes dependent on Pol II pausing stimulates transcription by promoting Pol II release in a human triple-negative breast cancer cell model. Histone variants RNA polymerase II-paused genes Gene expression Chromatin structure Cellular migration Breast cancer H2020...

... -null cells. Analyses of primary cultures of skin keratinocytes from a mouse strain expressing K17 with a mutated NLS corroborated these findings. Proteomics screens identified K17-interacting nuclear proteins with known roles in gene expression, chromatin organization and RNA processing. Key histone...

... that is essential for viability in flies, but is not required for DNA replication. Dbf4 Gcn5 Cell cycle Gene expression Histone acetylation American Cancer Society 10.13039/100000048 58-006-53 National Institutes of Health 10.13039/100000002 P30 CA023168 National...

... in any medium provided that the original work is properly attributed. Summary: Δ40p53 exerts tumor suppressor activity that is associated with upregulation of p53-target gene expression and induces senescence in hepatocellular carcinoma cell lines. Δ40p53 Gene targeting Liver cancer...

... but to a lesser extent. Therefore, a complete CWI transcriptional response requires not only phosphorylation of Rlm1 by Slt2 but also concurrent SLT2 - and RLM1 -mediated positive-feedback mechanisms; sustained patterns of gene expression are mainly achieved by positive autoregulatory circuits based...

... Extracellular vesicle Exosome Gene expression microRNA Cell stress Liver cancer Hypoxia linc-RoR Hepatocellular cancer (HCC) is the fifth most common cancer in men and the seventh most common cancer in women worldwide ( El-Serag, 2012 ). HCC is a highly treatment-resistant malignancy...

... in transfection efficiency. All of the reporter constructs were verified by sequencing. The miRNA expression data were acquired on the Illumina Human v2 miRNA platform (with 1146 miRNA probes) and the mRNA expression data was acquired on the Illumina Human HT-12 v4 gene expression microarray (>40,000...

... periphery has drawn much attention due to its role as a sub-nuclear compartment involved in virulence gene expression. Recent data have implicated components of the nuclear envelope in regulating gene expression in several eukaryotes. Special attention has been given to nucleoporins that compose the nuclear...

... transcriptional activity is enhanced in the presence of plakoglobin. Our data suggest that plakoglobin regulates gene expression in conjunction with p53 and that plakoglobin may regulate p53 transcriptional activity, which may account, in part, for the tumor/metastasis suppressor activity of plakoglobin...

... glycoprotein gene expression sites, although many members of this diverse family are also transcribed elsewhere in the genome. ESAG9 genes are among the most highly regulated genes in transmissible stumpy forms, encoding a group of secreted proteins of cryptic function. To understand their developmental...

... for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is progressively reduced during heart development without reduction of its own transcript. Simultaneous reduction of histone deacetylase (HDAC) expression prompted us to investigate the potential...

... to define their phenotype as slow or fast twitch muscle fibers. We have previously shown that voltage-gated L-type calcium channel (Cav1.1) acts as a voltage sensor for activation of inositol (1,4,5)-trisphosphate [Ins(1,4,5) P 3 ]-dependent Ca 2+ signals that regulates gene expression. ATP released...

... polarized hepatocyte-like cells (HLCs) from hFHPCs. Global gene expression profiling was performed on triplicate samples of hFHPCs, immature-HLCs and mature-HLCs. When the differential gene expression was compared based on the differentiation stage, a number of genes were identified that might be essential...

... ( [email protected] ; [email protected] ) 3 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Actin-related protein Histone variant Nuclear organization Chromosome territory Gene expression Various chromatin remodeling and histone modification...

...Kanako Watanabe; Yuki Akimoto; Katsuyuki Yugi; Shinsuke Uda; Jaehoon Chung; Shinichi Nakamuta; Kozo Kaibuchi; Shinya Kuroda A latent process involving signal transduction and gene expression is needed as a preparation step for cellular function. We previously found that nerve growth factor (NGF...

...Laura Leitner; Dmitry Shaposhnikov; Alexander Mengel; Arnaud Descot; Sylvia Julien; Reinhard Hoffmann; Guido Posern Monomeric actin regulates gene expression through serum response factor (SRF) by inhibiting its transcriptional coactivator myocardin-related transcription factor (MAL/MRTF). Many...

... address: S. De Bellis Scientific Institute, 70013 Castellana Grotte, Bari, Italy 1 6 2011 © 2011. 2011 PC12 cells NT2/D1 cells Neural cell differentiation Neurosecretion Gene expression The RE-1-specific silencing transcription factor (REST, also referred to as NRSF...