...-stimulated translocation of the GATA transcription factor GtaC as indicated by the distribution of a GFP–GtaC reporter. Erk2 was also found to be essential for the translocation of GtaC in response to external folate, a foraging signal that directs the chemotaxis of amoeba to bacteria. Erk1, the only other...

... nervous system (CNS) causes impaired closure of the rostral neural tube at embryonic stage (E) 9.0. Similar neural tube defects (NTDs) have previously been attributed to impaired folate metabolism in mice. We therefore asked whether LRP2 might be required for the delivery of folate to neuroepithelial...

[email protected] ) 21 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 Folate Signal transduction Motility Polarity Chemotaxis Chemotaxis is the directed migration of cells towards or away from gradients of signaling molecules. This migratory process is implicated...

...′,5′-cyclic phosphate. Proc. Natl. Acad. Sci. USA 58 , 1152 -1154. Laevsky, G. and Knecht, D. A. ( 2001 ). Under-agarose folate chemotaxis of Dictyostelium amoebae in permissive and mechanically inhibited conditions. Biotechniques 31 , 1140 -1149. Liu, X., Osherov, N., Yamashita...

...John J. Turek; Philip S. Low ABSTRACT It has been demonstrated that proteins covalently conjugated to folic acid may be taken up by cells via endo-cytosis after binding to a folate binding protein (FBP) in the cell membrane. The proteins taken up in this manner remain catalytically active...

...H. S. Tillinghast; P. C. Newell ABSTRACT Following a previous study indicating a sensitivity to folate during the developmental phase of Dictyostelium discoideum , a series of pteridines were investigated for their ability to induce amoebal chemotaxis during development of this organism. Several...

... of this drug on cyclic GMP formation induced by chemoattractants were reassessed. It was found that TMB-8 abolished both folate and cyclic AMP-mediated accumulation of cyclic GMP in D. discoideum amoebae and that addition of Ca 2+ completely restored this response. Tire Ca 2+ chelating agent EGTA did not mimic...