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1-20 of 51
Keywords: fibroblasts
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (11): jcs260688.
Published: 8 June 2023
... is not fully understood. Here, we found that primary fibroblasts isolated from aged mice (24 months old) exhibit an increased level of chromosome missegregation and micronucleation compared with that from young mice (2 months old), concomitant with an increased rate of aneuploid cells, suggesting the emergence...
Includes: Supplementary data
Journal Articles
Mei Sun, Devon Cogswell, Sheila Adams, Yasmin Ayoubi, Ambuj Kumar, Tea Reljic, Marcel Y. Avila, Curtis E. Margo, Edgar M. Espana
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (1): jcs258694.
Published: 12 January 2022
... 11 2021 © 2022. Published by The Company of Biologists Ltd 2022 Summary: Collagen XI, a minor fibrillar collagen, is expressed in mouse corneal stroma during early development and following injury in adults to regulate collagen fibrillogenesis. Regeneration Stroma Fibroblasts...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
Georgios Efthymiou, Agata Radwanska, Anca-Ioana Grapa, Stéphanie Beghelli-de la Forest Divonne, Dominique Grall, Sébastien Schaub, Maurice Hattab, Sabrina Pisano, Mallorie Poet, Didier F. Pisani, Laurent Counillon, Xavier Descombes, Laure Blanc-Féraud, Ellen Van Obberghen-Schilling
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (4): jcs252957.
Published: 24 February 2021
... remains unclear. Leveraging a unique biological toolset and image analysis pipeline for direct comparison of the variants, we demonstrate that the presence of one or both extra domains impacts FN assembly, function and physical properties of the matrix. When presented to FN-null fibroblasts, extra domain...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Dubravka Škalamera, Alexander J. Stevenson, Anna Ehmann, Stephen A. Ainger, Catherine Lanagan, Richard A. Sturm, Brian Gabrielli
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (24): jcs234716.
Published: 13 December 2019
.... Fibroblasts High-content-imaging Keratinocytes Melanocytes Melanoma Time-lapse tracking Worldwide Cancer Research 10.13039/100011713 Smiling for Smiddy Mater Foundation Skin homeostasis depends on regulated interaction between melanocytes and keratinocytes...
Includes: Supplementary data
Journal Articles
The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis
Qi Sun, Jiao Miao, Jing Luo, Qi Yuan, Hongdi Cao, Weifang Su, Yang Zhou, Lei Jiang, Li Fang, Chunsun Dai, Ke Zen, Junwei Yang
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (6): jcs202317.
Published: 26 March 2018
...Qi Sun; Jiao Miao; Jing Luo; Qi Yuan; Hongdi Cao; Weifang Su; Yang Zhou; Lei Jiang; Li Fang; Chunsun Dai; Ke Zen; Junwei Yang ABSTRACT Renal fibrosis is a final common pathway of chronic kidney disease. Sustained activation of fibroblasts is considered to play a key role in perpetuating renal...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (5): jcs208223.
Published: 6 March 2018
.... Moreover, a stiff extracellular matrix dampens the oscillations of the epithelial molecular clock. Here, we extend this analysis to other tissues and cell types, and identify an inverse relationship between circadian clocks in epithelia and fibroblasts. Epithelial cells from mammary gland, lung and skin...
Includes: Supplementary data
Journal Articles
Chibeza C. Agley, Anthea M. Rowlerson, Cristiana P. Velloso, Norman R. Lazarus, Stephen D. R. Harridge
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (24): 5610–5625.
Published: 15 December 2013
... predominantly of myogenic cells (CD56 + , desmin + ) and fibroblasts (TE-7 + , collagen VI + , PDGFRα + , vimentin + , fibronectin + ). To evaluate the behaviour of the cell types obtained, we optimised a double immuno-magnetic cell-sorting method for the separation of myogenic cells from fibroblasts...
Includes: Supplementary data
Journal Articles
Kyle J. Hewitt, Yulia Shamis, Elana Knight, Avi Smith, Anna Maione, Addy Alt-Holland, Steven D. Sheridan, Stephen J. Haggarty, Jonathan A. Garlick
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (9): 2276–2287.
Published: 1 May 2012
... in the function of fibroblasts in tissue homeostasis and regeneration. In this study, we characterized the expression of PDGFRβ in fibroblasts derived from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), and showed that this expression is important for cellular functions...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (19): 4427–4436.
Published: 1 October 2005
... culture. In most situations in vivo, however, matrix assembly occurs within existing three-dimensional (3D) extracellular matrix networks. In an attempt to mimic this environment, we analyzed matrix assembly by fibroblasts cultured on a pre-assembled 3D fibronectin matrix and found significant stimulation...
Journal Articles
Florence Debacq-Chainiaux, Céline Borlon, Thierry Pascal, Véronique Royer, François Eliaers, Noëlle Ninane, Géraldine Carrard, Bertrand Friguet, Françoise de Longueville, Sophie Boffe, José Remacle, Olivier Toussaint
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (4): 743–758.
Published: 15 February 2005
...Florence Debacq-Chainiaux; Céline Borlon; Thierry Pascal; Véronique Royer; François Eliaers; Noëlle Ninane; Géraldine Carrard; Bertrand Friguet; Françoise de Longueville; Sophie Boffe; José Remacle; Olivier Toussaint Premature senescence of human diploid fibroblasts (HDFs) can be induced...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (5): 667–675.
Published: 15 February 2004
...J. Michael Sorrell; Arnold I. Caplan Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at least three distinct subpopulations of fibroblasts, which occupy unique niches in the dermis...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (17): 3471–3478.
Published: 1 September 2003
.... * Author for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2003 2003 Chemotaxis Dictyostelium PI 3-kinase Fibroblasts Neutrophils Actin Chemotaxis, movement of a cell towards a chemoattractant signal, is a fundamental process involved in a wide...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1997) 110 (7): 861–870.
Published: 1 April 1997
...Doris Greiling; Richard A. F. Clark ABSTRACT After injury, the wound space is filled with a fibrin/fibronectin clot containing growth factors released by platelets and monocytes. In response to these factors, fibroblasts migrate into the fibrin clot and contribute to the formation of granulation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 106 (1): 343–354.
Published: 1 September 1993
... that have already become oriented with topographic features of the substratum. The purpose of this study was to examine the sequence in which microtubules, focal contacts and microfilament bundles become aligned to the substratum topography as fibroblasts spread on grooved substrata. Human gingival...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 105 (2): 423–432.
Published: 1 June 1993
...Miriam Griffin; Rena Bhandari; Graham Hamilton; Yiu-Che Chan; Janet T. Powell ABSTRACT During alveolar development and alveolar repair close contacts are established between fibroblasts and lung epithelial cells through gaps in the basement membrane. Using co-culture systems we have investigated...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 105 (2): 317–331.
Published: 1 June 1993
... from still images obtained in time-lapse via automated image analysis. We present the first quantitative correlation of contact guidance (based on cell orientation) with collagen fibril orientation (based on birefringence) for human foreskin fibroblasts cultured in a collagen gel, by using gels...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 104 (2): 399–407.
Published: 1 February 1993
..., vasopressin and bradykinin are inactive. The inhibitory activity of serum may be due to phos-pholipids, since it can be replaced by lysophosphatidic acid in the presence of serum albumin. * Author for correspondence © 1993 by Company of Biologists 1993 fibronectin fibroblasts cell shape...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1992) 103 (4): 1065–1072.
Published: 1 December 1992
... in proliferating cells and compounds needed for growth activation of arrested cells. By using time-lapse video recording we have studied the possible regulatory role of cholesterol, dolichol and mevalonate in the cell cycle of human diploid fibroblasts (HDF). HDF, which are serum-dependent, were rapidly growth...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1992) 102 (2): 315–322.
Published: 1 June 1992
... by human foreskin fibroblasts. Contraction was quantified as loss in gel weight. Both PDGF-A A and PDGF-BB were found to induce a rapid collagen-gel contraction. TGF- β 1 also stimulated gel contraction but with a delayed onset and at a slower rate than the PDGF-stimulated contraction. Rabbit polyclonal...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1992) 102 (1): 113–121.
Published: 1 May 1992
... have compared the patterns of RAR expression in human keratinocytes and dermal fibroblasts in vitro , and studied the effects of retinoic acid on RAR expression. RAR-α and RAR-γ were expressed in keratinocytes and fibroblasts: RAR-γ was expressed at similar levels in both cell types but RAR-α was more...
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