..., with enhancement of localised secretion of matrix metalloproteinases responsible for extracellular matrix remodelling. Inhibition of matrix metalloproteinase activity results in a robust rescue of the vascular expansion elicited by heightened c-Src activity. This supports the premise that moderating focal adhesion...

... of muscle stem cells and their progeny is crucial in strategizing remedies for pathological dysregulation of these cues in aging and disease. In this study, we investigated the cell-level influences of extracellular matrix (ECM) ligands and culture substrate stiffness on primary human myoblast contractility...

...Samuele Metti; Francesco Da Ros; Giorgia Toniato; Matilde Cescon; Paolo Bonaldo ABSTRACT Adult muscle stem cells (MuSCs) are critical for muscle homeostasis and regeneration, and their behavior relies on a finely regulated niche made of specific extracellular matrix (ECM) components and soluble...

...Rebeka Tomasin; Ana Maria Rodrigues; Antonio Carlos Manucci; Alexandre Bruni-Cardoso ABSTRACT Cell context is key for cell state. Using physiologically relevant models of laminin-rich extracellular matrix (lrECM) induction of mammary epithelial cell quiescence and differentiation, we provide...

...Petar B. Petrov; James M. Considine; Valerio Izzi; Alexandra Naba ABSTRACT The extracellular matrix (ECM) is a complex meshwork of proteins that forms the scaffold of all tissues in multicellular organisms. It plays crucial roles in all aspects of life – from orchestrating cell migration during...

... of Biologists Ltd 2023 Summary: A review of how hemidesmosomes are emerging as playing a crucial role in tissue maintenance, healthy aging and mechanotransduction across different organisms. Hemidesmosome Mechanosignaling YAP1 Healthy aging Extracellular matrix Regeneration...

... of pancreatic tumours is extensive fibrosis and deposition of extracellular matrix (ECM). While pancreatic cancer cells are programmed by stimuli derived from a stiff ECM, metastasis requires loss of attachment and adaptation to a softer microenvironment at distant sites. Growing evidence suggests that stiff...

... plasticity and self-renewal activity. Adhesion of basal cells to laminin α5-containing matrix controls their function by directing them towards a luminal cell fate. Mammary epithelium Progenitor activity Cell identity Adhesion Extracellular matrix Basement membrane Laminin Academy...

...Vinay Kumar Dubey; Souradeep R. Sarkar; Vairavan Lakshmanan; Rimple Dalmeida; Akash Gulyani; Dasaradhi Palakodeti ABSTRACT Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital...

...Xuekai Xiong; Weini Li; Jin Nam; Meng Qu; Steve A. Kay; Ke Ma ABSTRACT The circadian clock is entrained to daily environmental cues. Integrin-linked signaling via actin cytoskeleton dynamics transduces physical niche cues from the extracellular matrix to myocardin-related transcription factor (MRTF...

... by either cell–extracellular matrix adhesion or cell–cell adhesion, and both the mechanisms and consequences of inter-tissue adhesion have been studied in vivo in numerous vertebrate and invertebrate species. In this Review, we discuss recent progress in understanding the many functions of inter-tissue...

...John Hellicar; Nicola L. Stevenson; David J. Stephens; Martin Lowe ABSTRACT The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation...

.... Introducing leukocytes into the vessels allowed real-time visualization of all different steps of the leukocyte transmigration cascade, including migration into the extracellular matrix. Individual cell tracking over time distinguished striking differences in migratory behaviour between T-cells...

... the possible synergistic effects of different extracellular matrix components, and might have important roles in cell adhesion and migration in vivo. In particular, since formation of filopodia has been shown to correlate with cancer cell metastasis ( Arjonen et al., 2011 ; Jacquemet et al., 2015 ), our...

...Wenting Bu; Zarina Levitskaya; Suet-Mien Tan; Yong-Gui Gao ABSTRACT Integrin-mediated cell–extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. Kindlins are important positive regulators of integrin activation. The FERM-domain...

... and provide a first step for the development of a generative model of FN networks to unravel assembly mechanisms and investigate the physical and functional versatility of extracellular matrix landscapes. This article has an associated First Person interview with the first author of the paper...

... and truncated EGFR transcriptionally represses integrins via a SHC–MEK signaling axis, and communicates with neighboring cells through TNFα to promote cooperative invasion. Cancer Extracellular matrix Adhesion Invasion National Institutes of Health 10.13039/100000002 R01CA206880...

... into tumour–microenvironment interactions have led to ideas on targeting it as treatments. Microenvironment Cancer Extracellular matrix Mechanobiology Signalling In tissue biology, the terms stroma or microenvironment have been used to distinguish supporting tissue from the parenchyma...

...Marilyn Janice Oentaryo; Anna Chung-Kwan Tse; Chi Wai Lee ABSTRACT Agrin is a crucial factor that induces postsynaptic differentiation at neuromuscular junctions (NMJs), but how secreted agrin is locally deposited in the context of extracellular matrix (ECM) environment and its function...

... of endothelial damage. This introduces a novel control over VWF function. Weibel–Palade bodies von Willebrand Factor Extracellular matrix RGS4 Constitutive secretion British Heart Foundation 10.13039/501100000274 PG/14/76/31087 Medical Research Council 10.13039/501100000265...