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Keywords: exocytosis
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Membrane trafficking
J Cell Sci (2023) 136 (6): jcs260366.
Published: 5 March 2023
...Franziska Lehne; Sven Bogdan ABSTRACT Exocytosis is a fundamental cellular process by which cells secrete cargos from their apical membrane into the extracellular lumen. Cargo release proceeds in sequential steps that depend on coordinated assembly and organization of an actin cytoskeletal network...
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Membrane trafficking
J Cell Sci (2022) 135 (22): jcs260132.
Published: 21 November 2022
...Hanna C. A. Lammertse; Alessandro Moro; Ingrid Saarloos; Ruud F. Toonen; Matthijs Verhage ABSTRACT MUNC18-1 (also known as syntaxin-binding protein-1, encoded by Stxbp1 ) binds to syntaxin-1. Together, these proteins regulate synaptic vesicle exocytosis and have a separate role in neuronal...
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J Cell Sci (2022) 135 (18): jcs260107.
Published: 21 September 2022
... extracellular polyP inhibits exocytosis of undigested or partially digested nutrients. PolyP decreases plasma membrane recycling and apparent cell membrane fluidity, and this requires the G protein-coupled polyP receptor GrlD, the polyphosphate kinase Ppk1 and the inositol hexakisphosphate kinase I6kA. PolyP...
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Membrane trafficking
J Cell Sci (2021) 134 (11): jcs246694.
Published: 8 June 2021
...Cristina Escrevente; Liliana Bento-Lopes; José S. Ramalho; Duarte C. Barral ABSTRACT Lysosomes are dynamic organelles, capable of undergoing exocytosis. This process is crucial for several cellular functions, namely plasma membrane repair. Nevertheless, the molecular machinery involved...
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J Cell Sci (2020) 133 (10): jcs241141.
Published: 27 May 2020
... place across the Golgi. GEF Golgi RAB GTPase Exocytosis Multisubunit tethering complex Ministerio de Ciencia, Innovación y Universidades  BIO2015-65090R RTI2018-093344-B-I00 Comunidad de Madrid 10.13039/100012818 S2017/BMD-3691 InGEMICS-CM Transport protein...
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Journal Articles
J Cell Sci (2020) 133 (5): jcs240424.
Published: 21 February 2020
...Prasad V. Phatarpekar; Daniel D. Billadeau; Ana-Maria Lennon-Duménil ABSTRACT Natural killer (NK) cells, cytolytic lymphocytes of the innate immune system, play a crucial role in the immune response against infection and cancer. NK cells kill target cells through exocytosis of lytic granules...
Journal Articles
J Cell Sci (2020) 133 (3): jcs233791.
Published: 12 February 2020
... provides insights into actin-mediated regulation of exocytosis . J. Cell Biol.   217 , 945 - 957 . 10.1083/jcb.201705084 Vidali , L. , Augustine , R. C. , Kleinman , K. P. and Bezanilla , M. E. ( 2007 ). Profilin is essential for tip growth in the moss Physcomitrella patens...
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Journal Articles
J Cell Sci (2020) 133 (2): jcs236737.
Published: 22 January 2020
...://www.biologists.com/user-licence-1-1/ Highlighted Article: The neuronal endocytic adaptor protein AP180 has a dual role in the clearance of release sites and in membrane retrieval in inner hair cells of the murine cochlea. AP180 SNAP91 Ribbon synapse Exocytosis Endocytosis Hearing Electron...
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J Cell Sci (2020) 133 (5): jcs234781.
Published: 10 October 2019
... Ltd 2019 Summary: Why is membrane trafficking rate-limiting for release of constitutively secreted interleukin-6? We propose that cells monitor and adjust cytokine secretion rates for prevention of septic shock. Cytokine secretion Exocytosis Interleukin 6 Membrane trafficking...
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Organelles
J Cell Sci (2019) 132 (9): jcs228544.
Published: 30 April 2019
... granule exocytosis. Ca 2+ , in turn, is also rapidly taken up by the mitochondria and exerts important feedback regulation of metabolism. The aim of this study was to determine whether the distribution of mitochondria within beta cells is important for the secretory capacity of these cells. We find...
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Journal Articles
J Cell Sci (2019) 132 (7): jcs227165.
Published: 5 April 2019
...Jeffrey S. Dason; Aaron M. Allen; Oscar E. Vasquez; Marla B. Sokolowski ABSTRACT Sustained neurotransmission requires the tight coupling of synaptic vesicle (SV) exocytosis and endocytosis. The mechanisms underlying this coupling are poorly understood. We tested the hypothesis that a cGMP-dependent...
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Journal Articles
J Cell Sci (2019) 132 (5): jcs221952.
Published: 15 February 2019
...Camille Lenzi; Jennifer Stevens; Daniel Osborn; Matthew J. Hannah; Ruben Bierings; Tom Carter ABSTRACT Elevations of intracellular free Ca 2+ concentration ([Ca 2+ ] i ) are a potent trigger for Weibel–Palade body (WPB) exocytosis and secretion of von Willebrand factor (VWF) from endothelial cells...
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Journal Articles
J Cell Sci (2018) 131 (23): jcs217638.
Published: 30 November 2018
... in secretion of a STAT-activating cytokine. Live imaging suggests that changes in intracellular Ca 2+ are linked to this event. Our data suggest a cell-type specific requirement for particular vesicle trafficking components in regulated exocytosis during development. Given the central role for STAT signaling...
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Journal Articles
J Cell Sci (2018) 131 (23): jcs213017.
Published: 29 November 2018
...Chien-Chang Huang; Tai-Yu Chiu; Tzu-Ying Lee; Hsin-Jui Hsieh; Chung-Chih Lin; Lung-Sen Kao ABSTRACT α-Synuclein is associated with Parkinson's disease, and is mainly localized in presynaptic terminals and regulates exocytosis, but its physiological roles remain controversial. Here, we studied...
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Journal Articles
J Cell Sci (2018) 131 (16): jcs218610.
Published: 17 August 2018
...://www.biologists.com/user-licence-1-1/ Highlighted Article: Cholera toxin inhibits the exocytosis function of the SNX27-retromer complex, thereby inhibiting cargo trafficking to the PM. SNX27 Retromer NHE3 PDZ Secretory diarrhea Apical trafficking Exocytosis Cholera toxin Early endosomes...
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Imaging
J Cell Sci (2017) 130 (15): 2591–2605.
Published: 1 August 2017
... is von Willebrand factor (VWF) which, following stimulation with secretagogues, is released into the blood vessel lumen as large platelet-catching strings. This exocytosis changes the protein composition of the cell surface and also results in a net increase in the amount of plasma membrane. Compensatory...
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Journal Articles
J Cell Sci (2016) 129 (21): 3989–4000.
Published: 1 November 2016
...-licence-1-1/ Highlighted Article: Kiss-and-run and cavicapture are the dominant mechanisms associated with granule replenishment in mast cells after IgE-mediated degranulation. Kiss-and-run Cavicapture Exocytosis Endocytosis Proteoglycan Mast cell Mast cells are long-lived...
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Journal Articles
J Cell Sci (2016) 129 (10): 2085–2095.
Published: 15 May 2016
... targeting of Akt to a region of the cell marked the sites where IRAP–pHluorin vesicles fused, supporting the idea that local Akt-mediated signaling regulates exocytosis. Taken together, these results indicate that PI3K and Akt play distinct roles, and that PI3K stimulates Akt-independent pathways...
Includes: Supplementary data