... maintenance and remodeling . Mol. Biol. Cell 33 , ar136 . 10.1091/mbc.E22-06-0205 Claude , P. and Goodenough , D. A. ( 1973 ). Fracture faces of zonulae occludentes from “tight” and “leaky” epithelia . J. Cell Biol. 58 , 390 - 400 . 10.1083/jcb.58.2.390 Dubrovskyi...

... methods for interrogating the initiation of ADPKD cystogenesis. 3D cell model Epithelia Kidney Tubulogenesis Collecting duct Polycystic kidney disease In vitro models of stem cell differentiation and kidney development have set the stage for expanding our understanding...

... and Myosin II balance regulates an optimal lateral furrow length for transition of a circular to a polygonal plasma membrane organization in cortical syncytial division cycles in Drosophila embryogenesis. Syncytium Embryo Epithelia Polygon Drosophila DE-cadherin Myosin II Spherical...

... function in the face of cell and tissue dynamics. Actomyosin Barrier function Epithelia Morphogenesis Tight junction Paracellular permeability Epithelia aid in organizing the body by creating tissue barriers – sheets of connected cells with the ability to regulate the quantity and type...

... polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type. Cdc42 Epithelia MRCK PAK Par complex Polarity Cell polarity – the asymmetric distribution of membrane domains, cytoskeletal components and organelles – is a fundamental feature of cells...

... that together promote the fast and efficient closure of tissue discontinuities. The Grainy head family of transcription factors (Grh in flies; GRHL1–GRHL3 in mammals) are essential proteins that have been implicated both in the development and repair of epithelia. However, the genes and the molecular mechanisms...

... feature of epithelial and polarised cells. This Review presents the dynamics of cortical domains in early Drosophila embryos and discusses underlying mechanisms for formation of cortical domains. Drosophila F-actin Cortical compartment Cortical domain Epithelia Below the plasma...

..., epithelia at mucosal surfaces must allow selective paracellular flux that discriminates between solutes and water while preventing the passage of bacteria and toxins. In vertebrates, tight junctions seal the paracellular space; flux across the tight junction can occur through two distinct routes that differ...

...George T. Eisenhoffer; Gloria Slattum; Oscar E. Ruiz; Hideo Otsuna; Chase D. Bryan; Justin Lopez; Daniel S. Wagner; Joshua L. Bonkowsky; Chi-Bin Chien; Richard I. Dorsky; Jody Rosenblatt; Andrew Ewald ABSTRACT Epithelia provide a crucial protective barrier for our organs and are also the sites...

.... PRL-3 PTP4A3 Midbody Cell polarity Epithelia Cancer Defects in polarized epithelial tissue architecture are the source of more than 80% of human cancers, and deregulation or loss of polarity in epithelial cells is considered fundamental during tumor progression ( Datta et al., 2011...

... remains unclear. Here, we examine the hierarchy of events during cytoskeletal polarisation in Drosophila melanogaster epithelia. Core apical-basal polarity determinants polarise the spectrin cytoskeleton to recruit the microtubule-binding proteins Patronin (CAMSAP1, CAMSAP2 and CAMPSAP3 in humans...

... ). Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia . Proc. Natl. Acad. Sci. USA   92 , 10629 - 10633 . 10.1073/pnas.92.23.10629 O'Brien , L. E. , Zegers , M. M. P. and Mostov , K. E. ( 2002 ). Opinion: building epithelial...

.... , Loftus   P. D. , Yoshigi   M. , Otsuna   H. , Chien   C. B. , Morcos   P. A. , Rosenblatt   J. ( 2012 ). Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.   Nature   484 , 546 – 549 . 10.1038/nature10999 Fadok   V. A. , Bratton   D. L...

... protein kinase.   Proc. Natl. Acad. Sci. USA   104 , 819 – 822 . 10.1073/pnas.0610157104 * Author for correspondence ( michael.caplan@yale.edu ) 27 08 2013 © 2013. Published by The Company of Biologists Ltd 2013 Calcium-sensing receptor Epithelia Tight junction...

... differentiation. * Author for correspondence ( m.mogensen@uea.ac.uk ) 31 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 EB2 EB1 ACF7 Epithelia Microtubules Cochlea Intestinal crypt Actin filaments Microtubule reorganisation is critical for differentiation...

... suited to coalesce and reorganize actin bundles within the filopodia. * Author for correspondence ( skhurana@uh.edu ) 13 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 Villin Actin Bundling PtdIns(4,5) P 2 Metastasis Epithelia Filopodia Cell migration...

... and structure of the polarised epithelial actin cytoskeleton. * Author for correspondence ( marios.georgiou@ucl.ac.uk ) 12 1 2010 © 2010. 2010 Par Polarity Epithelia Rho-GTPases Protrusions Actin Animal cells are able to form a number of distinct dynamic actin-filament-based...

... of the complex is restricted to a distinct region of the apical plasma membrane that abuts the zonula adherens in epithelia and photoreceptor cells of invertebrates and vertebrates, including humans. In addition to the core components, a variety of other proteins can be recruited to the complex, depending...

... epithelia ( Peto, 2001 ), and the proliferation and differentiation of epithelial cells are crucially dependent on the EGFR ( Arteaga, 2002 ; Miettinen et al., 1995 ; Sibilia and Wagner, 1995 ; Threadgill et al., 1995 ; Yarden, 2001 ). The EGFR plays fundamental roles in carcinogenesis. EGFR...

...Nicole Gorfinkiel; Alfonso Martinez Arias Dynamic interactions between epithelial sheets are a regular feature of morphogenetic processes. Dorsal closure in Drosophila relies on the coordinated movements of two epithelia, the epidermis and the amnioserosa, and provides an excellent model system...