...Benjamin William Walters; Tiak Ju Tan; Chew Teng Tan; Christabel Thembela Dube; Kang Ting Lee; Jace Koh; Yasmin Hui Binn Ong; Vanessa Xue Hui Tan; Fathima Rifkhana Shah Jahan; Xin Ni Lim; Yue Wan; Chin Yan Lim ABSTRACT The mammalian epidermis undergoes constant renewal, replenished by a pool...

.... Epidermis Skin Tumorigenesis Polarity Cell junction Cell adhesion Mitotic spindle orientation Epithelial organization National Institutes of Health 10.13039/100000002 R01AR072590 R01CA225463 Non-melanoma skin cancer, which includes basal cell carcinoma (BCC) and squamous cell...

... epidermis displays a highly ordered parallel stripe pattern as part of its subcellular structure, making it an ideal model to study the formation and reorganization of periodic patterns within cells. Here, we show that the initial formation of periodic striped patterns in the C. elegans epidermis...

... functions in the epidermis to instruct skin integrity. Significantly, we show that expression of a mouse RAB6A cDNA can rescue defects in C. elegans epidermis caused by lack of RAB-6.2, suggesting functional conservation across phyla. We also show that the novel function of RAB-6.2 in C. elegans cuticle...

... cells. Circadian clock Epithelial cell Fibroblast Breast Lung Epidermis Circadian gene expression Medical Research Council 10.13039/501100000265 G0900414 Biotechnology and Biological Sciences Research Council 10.13039/501100000268 Wellcome Trust 10.13039...

...-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis . J. Invest. Dermatol.   133 , 2191 - 2201 . 10.1038/jid.2013.66 Giarmarco , M. M. , Cleghorn , W. M. , Sloat , S. R. , Hurley , J. B. and Brockerhoff , S. E. (2017...

... embryos had reached embryonic day 9 (E9). After isolation of an embryo, its left lateral epidermis was wounded with a sewing needle. The wounded embryo was incubated in the embryonic medium (DMEM, 50% rat serum, 10 µM MEM-non-essential amino acids, and 1 mM 2-mercaptoethanol) at 37°C for 5 or 20 min...

... differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension. Comparison of normal skin with keloid scar tissue further revealed an upregulation of EGF signaling within the epidermis...

... Breast Lung Epidermis Circadian gene expression Medical Research Council 10.13039/501100000265 G0900414 Biotechnology and Biological Sciences Research Council 10.13039/501100000268 Wellcome Trust 10.13039/100010269 088785/Z/09/Z Most organisms have...

... of 0.99 μm, through the epidermis and the upper region of the mesophyll on the adaxial surface of the most expanded leaves. Standard deviation z -projections were obtained using the function in ImageJ (Schneider et al., 2012) and the number of plastids exhibiting or lacking stromules was counted manually...

... that the JAK/STAT pathway suppressed cell fusion during wound healing in the Drosophila larval epidermis, restricting cell fusion to the vicinity of the wound. In the absence of JAK/STAT signaling, a large syncytium containing a 3-fold higher number of nuclei than observed in wild-type tissue formed in wounded...

... skin stem cells (Salemi et al., 2012). We translated our findings in an organotypic skin model to challenge putative in vivo effects of autophagosome formation during the development of the epidermis. 3-MA treatment prevents epidermal stratification even in skin reconstructs composed of iASPP...

... homeostasis. To elucidate the in vivo function of the p18-mediated pathway, we conditionally ablated p18 in the mouse epidermis. Mutant mice were born with severe defects in formation of the stratum corneum and died within 12 h after birth due to dehydration caused by loss of skin barrier function. Mutant...

... polarity proteins in a range of in vivo processes, including stem cell behavior, cell fate determination, junction formation and maintenance and organ development. Using the epidermis of the skin as a model system, this Commentary aims to discuss the in vivo significance of cell and tissue polarity...

...E. Douglas Robertson; Lynda Weir; Malgorzata Romanowska; Irene M. Leigh; Andrey A. Panteleyev Summary Previously we showed that spatial and developmental modulation of ARNT (HIF1β) expression in mouse epidermis is essential for maintenance of keratinocyte differentiation, proper formation...

...Lee Wallace; Leiann Roberts-Thompson; Julia Reichelt Keratins K1 and K10 are the most abundant proteins in the upper epidermis where they polymerize to form intermediate filaments (IFs). In addition to their well-established function in providing epidermal stability, K1/K10 (i.e. the dimer between...

...Hamid Reza Rezvani; Nsrein Ali; Martin Serrano-Sanchez; Pierre Dubus; Christine Varon; Cécile Ged; Catherine Pain; Muriel Cario-André; Julien Seneschal; Alain Taïeb; Hubert de Verneuil; Frédéric Mazurier In mouse and human skin, HIF-1α is constitutively expressed in the epidermis, mainly...

... reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In this study, Panx1 and Panx3 were detected in the epidermis of 13.5 day embryonic mice. Compared with newborn mice, there was less Panx1 expression in both...

...., Wallace, I. M., Wilm, A., Lopez, R. et al. (2007). Clustal W and Clustal X version 2.0. Bioinformatics 23 , 2947 -2948. Lechler, T. and Fuchs, E. (2007). Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. J. Cell Biol. 176 , 147 -154. Lewis, L., Barrandon...

...Emilie A. Leclerc; Anne Huchenq; Nicolas R. Mattiuzzo; Daniel Metzger; Pierre Chambon; Norbert B. Ghyselinck; Guy Serre; Nathalie Jonca; Marina Guerrin Corneodesmosin (CDSN) is specific to desmosomes of epithelia undergoing cornification, mainly the epidermis and the inner root sheath of the hair...