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Keywords: endocytosis
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Journal Articles
J Cell Sci jcs.258587.
Published: 08 September 2021
... adaptor, a key player in clathrin-mediated endocytosis, is a highly organized process controlled by alpha and gamma adaptin binding protein (AAGAB, also known as p34). In this work, we demonstrate that besides AP2, AAGAB also regulates the assembly of AP1, a cargo adaptor involved in clathrin-mediated...
Journal Articles
J Cell Sci (2021) 134 (10): jcs258603.
Published: 24 May 2021
... of cell-cell interaction. In our model, Rab11 and Disp pathways appear to compete for Hh. Rab11 promotes Hherisome formation after Hh endocytosis, whereas Disp extracts Hh from the plasma membrane. Our data suggest that the Rab11-dependent step is limited in the wild-type context. This limitation...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (3): jcs217356.
Published: 10 February 2021
.../caveolae-mediated but not clathrin-mediated endocytosis, on its tautomerase activity and, probably, on its thiol protein oxidoreductase activity. As MIF treatment restrained actin polymerisation in vitro , our findings establish a new intracellular role for MIF/D-DT in driving cell motility through...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs249524.
Published: 01 December 2020
...Matthias Corrotte; Mark Cerasoli; Fernando Y. Maeda; Norma W. Andrews ABSTRACT Endocytosis of caveolae has previously been implicated in the repair of plasma membrane wounds. Here, we show that caveolin-1-deficient fibroblasts lacking caveolae upregulate a tubular endocytic pathway and have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs246199.
Published: 12 October 2020
... that endocytosis is required for activation of a subset of Domeless targets. Our data indicate that endocytosis both qualitatively and quantitatively regulates Domeless signalling. STAT92E, the single STAT transcription factor in Drosophila , appears to be the target of endocytic regulation, and our studies show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs247684.
Published: 12 October 2020
...Thomas O. Tolsma; Hallie P. Febvre; Deanna M. Olson; Santiago M. Di Pietro ABSTRACT Endocytosis of plasma membrane proteins is mediated by their interaction with adaptor proteins. Conversely, emerging evidence suggests that adaptor protein recruitment to the plasma membrane may depend on binding...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (17): jcs239681.
Published: 01 September 2020
.../pnas.1309482110 Baschieri , F. , Dayot , S. , Elkhatib , N. , Ly , N. , Capmany , A. , Schauer , K. , Betz , T. , Vignjevic , D. M. , Poincloux , R. and Montagnac , G. ( 2018 ). Frustrated endocytosis controls contractility-independent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs245415.
Published: 21 August 2020
... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Coincidence detection of phosphorylated and ubiquitylated cargo-specific regions is used for epsin target recognition among multiple ubiquitylated proteins in yeast. Endocytosis Internalization Ena1 Epsin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243675.
Published: 14 August 2020
...Fiete Haack; Kai Budde; Adelinde M. Uhrmacher ABSTRACT Endocytosis plays a pivotal regulatory role in canonical WNT signaling. Internalization of the low-density lipoprotein receptor-related protein 6 (LRP6) receptor complex can either promote or attenuate canonical WNT signaling, depending...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244467.
Published: 09 July 2020
... a role for clathrin and/or endocytosis in the regulation of this pathway, but conflicting results exist and demand a deeper mechanistic understanding. We investigated the consequences of clathrin depletion on Wnt/β-catenin signaling in cell lines and found a pronounced reduction in β-catenin protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs242859.
Published: 06 July 2020
... that plays a crucial role in albumin absorption. To date, the mechanism of albumin endocytosis mediated by CUBAM remains to be elucidated. Here, we describe a quantitative assay to evaluate albumin uptake by CUBAM using cells expressing full-length CUBN and elucidate the crucial roles of the C-terminal part...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240861.
Published: 04 June 2020
...Francesco Baschieri; Kseniia Porshneva; Guillaume Montagnac ABSTRACT Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to cluster receptors and to locally bend...
Journal Articles
J Cell Sci (2020) 133 (10): jcs228114.
Published: 22 May 2020
...Åsa B. Birgisdottir; Terje Johansen ABSTRACT Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded...
Journal Articles
J Cell Sci (2020) 133 (3): jcs233791.
Published: 12 February 2020
... tagged formins coupled with examination of formin-null lines reveals that phylogenetically distinct formins differentially contribute to actin formation in plant cells. Actin Formin Plant Endocytosis Exocytosis Microtubule Formins are a diverse family of proteins found throughout...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs236737.
Published: 22 January 2020
... is required for clathrin-dependent endocytosis and SV reformation in IHCs. Moreover, AP180 deletion led to a high prevalence of SVs in a multi-tethered or docked state after stimulation, a reduced rate of SV replenishment and a hearing impairment. We conclude that, in addition to its role in clathrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs222992.
Published: 21 October 2019
... complex Clathrin Membrane traffic Endocytosis Golgi Hereditary spastic paraplegia Nearly a third of the proteins encoded by the human genome are predicted to be integral membrane proteins, all of which have to get to the right part of the cell. There are several ways of moving membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs233502.
Published: 11 September 2019
...Cameron Dale MacQuarrie; MariaSanta C. Mangione; Robert Carroll; Michael James; Kathleen L. Gould; Vladimir Sirotkin ABSTRACT Arp2/3 complex-nucleated branched actin networks provide the key force necessary for endocytosis. The Arp2/3 complex is activated by nucleation-promoting factors including...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 02 September 2019
... mediators of protein trafficking and the spatially dependent alterations in the dynamics of K ir 2.1 fluorescent recovery after photobleaching revealed that the K ir 2.1 channels are transported to the cell membrane uniformly, but are preferentially internalized by endocytosis at sites that are distal from...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (17): jcs232579.
Published: 02 September 2019
...Julie Loh; Mei-Chun Chuang; Shan-Shan Lin; Jophin Joseph; You-An Su; Tsung-Lin Hsieh; Yu-Chen Chang; Allen P. Liu; Ya-Wen Liu ABSTRACT Internalization of macromolecules and membrane into cells through endocytosis is critical for cellular growth, signaling and plasma membrane (PM) tension...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs232868.
Published: 15 August 2019
...-binding proteins in Arabidopsis that could have equivalent functions to ESCRT-0. We further hypothesise that SH3 domain-containing proteins might serve as membrane curvature-sensing endophilin and amphiphysin homologues during plant endocytosis. * These authors contributed equally to this work...