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Keywords: embryonic stem cells
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Journal Articles
J Cell Sci (2021) 134 (14): jcs255018.
Published: 29 July 2021
...) environments, such as early mammalian embryos and a variety of adult tissues. Here, we use mouse embryonic stem cells (ESCs), which grow in 3D colonies, as a model to investigate division in 3D. We observe that, at the periphery of 3D colonies, ESCs display high spindle mobility and divide asymmetrically. Our...
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Stem Cells
J Cell Sci (2020) 133 (20): jcs245845.
Published: 23 October 2020
...Federico Pecori; Yoshihiro Akimoto; Hisatoshi Hanamatsu; Jun-ichi Furukawa; Yasuro Shinohara; Yuzuru Ikehara; Shoko Nishihara ABSTRACT Mouse embryonic stem cells (ESCs) can differentiate into a range of cell types during development, and this pluripotency is regulated by various extrinsic...
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In collection:
Stem Cells
J Cell Sci (2020) 133 (15): jcs240176.
Published: 14 August 2020
... complex, which are required for the transcriptional repression in embryonic stem cells. PRDM14–CtBP1/2–PRC2 complex Transcriptional repression Pluripotency Embryonic stem cells Pluripotent cells are common sources of germline and somatic cells. They are established early in the mammalian...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs222257.
Published: 20 September 2018
... ABSTRACT The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3. However, the contribution of other ancillary pathways stimulated by LIF in ESCs, such as the MAPK and PI3K pathways, is less well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs206896.
Published: 12 February 2018
... form and provide a regulatory micro-environment remains to be elucidated. We employed the human embryonic stem cell-based neural rosette system to investigate the structural development and function of neural rosettes. Our study shows that neural rosette formation consists of five types...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (22): 3809–3817.
Published: 15 November 2017
...Kuisheng Liu; Yan Zhang; Dahai Liu; Qi-Long Ying; Shoudong Ye ABSTRACT TFCP2L1 is a transcription factor that is crucial for self-renewal of mouse embryonic stem cells (mESCs). How TFCP2L1 maintains the pluripotent state of mESCs, however, remains unknown. Here, we show that knockdown of Tfcp2l1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 788–803.
Published: 15 February 2016
...Christine Hofstetter; Justyna M. Kampka; Sascha Huppertz; Heike Weber; Andreas Schlosser; Albrecht M. Müller; Matthias Becker ABSTRACT Pluripotent embryonic stem cells (ESCs) are characterised by their capacity to self-renew indefinitely while maintaining the potential to differentiate into all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1961–1968.
Published: 15 May 2015
...Hermes Taylor-Weiner; Neeraja Ravi; Adam J. Engler ABSTRACT Pluripotent embryonic stem cells (ESCs) exert low-traction forces on their niche in vitro whereas specification to definitive endoderm in vivo coincides with force-mediated motility, suggesting a differentiation-mediated switch. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2603–2613.
Published: 15 June 2014
...Tim Pieters; Frans van Roy ABSTRACT Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and catenins – their cytoplasmic scaffold proteins – in the fate, maintenance and differentiation of mammalian...
Journal Articles
J Cell Sci (2014) 127 (10): 2204–2216.
Published: 15 May 2014
... 05 2013 4 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Embryonic stem cells Endoderm p38 MAP kinase Gastrulation BMP4 Two distinct endoderm lineages arise during mammalian embryogenesis – the primitive endoderm, a derivative of the inner cell mass (ICM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 752–762.
Published: 15 February 2014
...Sicong Zeng; Lvjun Liu; Yi Sun; Pingyuan Xie; Liang Hu; Ding Yuan; Dehua Chen; Qi Ouyang; Ge Lin; Guangxiu Lu ABSTRACT High telomerase activity is a characteristic of human embryonic stem cells (hESCs), however, the regulation and maintenance of correct telomere length in hESCs is unclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5391–5399.
Published: 1 December 2013
...-Tayeb et al., 2010 ). Compared with the factors described above that direct hepatic differentiation, the role of extracellular matrices (ECMs) and scaffolds remains unclear. Hepatic differentiation In vitro differentiation Embryonic stem cells Induced pluripotent stem cells © 2013...
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Journal Articles
J Cell Sci (2013) 126 (21): 5062–5073.
Published: 1 November 2013
... positively influences differentiation of embryonic neural precursors, as well as that of neural stem cells from adult neurogenic niches. To study the impact of cell-released BDNF on neural differentiation of embryonic stem cells (ESCs), which represent an attractive source for cell transplantation studies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1807–1813.
Published: 1 April 2012
... mosaic mice through the injection of wild-type (WT) embryonic stem cells (ESCs) into SGδ-knockout (KO) blastocysts. ESC-derived SGδ was supplied to the sarcolemma of 18-month-old chimeric muscle, which resulted in the restoration of the SGC. Despite SGC rescue, and contrary to previous observations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 1992–2000.
Published: 15 June 2011
...Heather K. Bone; Adam S. Nelson; Christopher E. Goldring; David Tosh; Melanie J. Welham The use of small molecules to ‘chemically direct’ differentiation represents a powerful approach to promote specification of embryonic stem cells (ESCs) towards particular functional cell types for use...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1819–1830.
Published: 1 June 2011
... VEGF stimulation, and might activate distinct signaling pathways that variegate cardiac-associated vasculogenesis versus cardiac-independent (yolk sac hemangioblast-derived) vascular differentiation ( Iida et al., 2005 ; Kattman et al., 2006 ). Embryonic stem cells Cardiovascular...
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Journal Articles
J Cell Sci (2011) 124 (7): 1136–1144.
Published: 1 April 2011
...) Finally, Oct3/4 activates transcription of Nanog , which in turn, negatively regulates TEAD2 through an unknown mechanism. * Author for correspondence ( cecilia.anneren@imbim.uu.se ) 18 11 2010 © 2011. 2011 Embryonic stem cells Leukemia inhibitory factor Self-renewal Src...
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Journal Articles
J Cell Sci (2011) 124 (3): 348–358.
Published: 1 February 2011
...Matthew J. Birket; Adam L. Orr; Akos A. Gerencser; David T. Madden; Cathy Vitelli; Andrzej Swistowski; Martin D. Brand; Xianmin Zeng Here, we have investigated mitochondrial biology and energy metabolism in human embryonic stem cells (hESCs) and hESC-derived neural stem cells (NSCs). Although stem...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2733–2742.
Published: 15 August 2010
... for correspondence ( skume@kumamoto-u.ac.jp ) 30 4 2010 © 2010. 2010 Embryonic stem cells Endoderm In vitro differentiation Pancreatic differentiation Synthesized basement membrane (sBM) Extracellular matrix Embryonic stem (ES) cells have an unlimited replicative ability...
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Journal Articles
J Cell Sci (2009) 122 (18): 3303–3311.
Published: 15 September 2009
... signaling directs vascular endothelial differentiation of VEGFR2 + mesodermal progenitors is not well understood. In this study, we examined the signal transduction pathway downstream of VEGFR2 for endothelial differentiation using an in vitro differentiation system of mouse embryonic stem-cell-derived...
Includes: Supplementary data