... on pharyngeal arch deficiency and found that pharyngeal arches in hspa8 mutant embryos exhibited induction of endoplasmic reticulum stress and activation of the unfolded protein response via the Perk/p-eIF2α/Atf4 signaling cascade. Inhibition of Perk/p-eIF2α/Atf4 signaling rescued the developmental deficiency...

.... Mechanistically, VRB and cortisone signaled through the integrated stress response mediated by eIF2α (also known as EIF2S1), yet induced different kinases, with cortisone activating the GCN2 kinase (also known as EIF2AK4). Cortisone increased VRB-induced cell death and reduced the population of cells trapped...

... XBP1 PERK eIF2α ATF4 ATF6 Pancreas Eye In eukaryotic cells, the endoplasmic reticulum (ER) serves as the primary site of folding and maturation of secretory and transmembrane proteins. Nascent polypeptides undergo a complex, multistep chaperone-assisted process of maturation to attain...

...Lucas C. Reineke; Shebna A. Cheema; Julien Dubrulle; Joel R. Neilson ABSTRACT Stress granules (SGs) assemble under stress-induced conditions that inhibit protein synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins or inactivation of mTORC1. Classically...

... and composition of stress granule-like foci, the translation-related mechanisms of their assembly and their connection to cell survival. Haploid cell Translational control Stress response Stress granules Translation initiation eIF2α National Institutes of Health 10.13039/100000002 GM111700...

...Jon Halvor Jonsrud Knutsen; Gro Elise Rødland; Cathrine Arnason Bøe; Tine Weise Håland; Per Sunnerhagen; Beáta Grallert; Erik Boye ABSTRACT Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α...

...Elke Malzer; Małgorzata Szajewska-Skuta; Lucy E. Dalton; Sally E. Thomas; Nan Hu; Helen Skaer; David A. Lomas; Damian C. Crowther; Stefan J. Marciniak Summary Phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by the kinase GCN2 attenuates protein synthesis during amino...

...Noelia Valbuena; Ana Elisa Rozalén; Sergio Moreno Summary Serine 51 phosphorylation of the eukaryotic initiation factor-2α (eIF2α) is an important mechanism involved in blocking general protein synthesis in response to diverse types of stress. In fission yeast, three kinases (Hri1, Hri2 and Gcn2...

... and hydrogen peroxide induce phosphorylation of eIF2α, a known Gcn2 target, and an arrest in G1 phase. By contrast, exposure to psoralen plus long-wavelength ultraviolet light, inducing DNA adducts and crosslinks, or to ionizing radiation induce neither eIF2α phosphorylation nor a cell-cycle delay. We conclude...