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Keywords: eIF2α
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Journal Articles
J Cell Sci (2019) 132 (5): jcs217216.
Published: 15 February 2019
... of ATF4 targets include growth arrest and DNA damage-inducible 34 (GADD34; also known as PPP1R15A) and constitutive repressor of eIF2α phosphorylation (CReP; also known as PPP1R15B) that help to de-phosphorylate phospho-eIF2α as part of a negative-feedback loop ( Connor et al., 2001 ; Fawcett et al...
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 05 October 2018
...Lucas C. Reineke; Shebna A. Cheema; Julien Dubrulle; Joel R. Neilson ABSTRACT Stress granules (SGs) assemble under stress-induced conditions that inhibit protein synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins or inactivation of mTORC1. Classically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 927–937.
Published: 01 March 2017
... ). Cells exposed to various stresses respond with the immediate shutoff of general protein synthesis, mediated by the inhibition of translation initiation via two key regulatory mechanisms. The first mechanism involves phosphorylation of the α-subunit of the eukaryotic initiation factor 2 (eIF2α, also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4420–4427.
Published: 01 December 2015
...Jon Halvor Jonsrud Knutsen; Gro Elise Rødland; Cathrine Arnason Bøe; Tine Weise Håland; Per Sunnerhagen; Beáta Grallert; Erik Boye ABSTRACT Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α...
Journal Articles
J Cell Sci (2013) 126 (6): 1406–1415.
Published: 15 March 2013
...Elke Malzer; Małgorzata Szajewska-Skuta; Lucy E. Dalton; Sally E. Thomas; Nan Hu; Helen Skaer; David A. Lomas; Damian C. Crowther; Stefan J. Marciniak Summary Phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by the kinase GCN2 attenuates protein synthesis during amino...
Journal Articles
J Cell Sci (2012) 125 (24): 5955–5959.
Published: 15 December 2012
...Noelia Valbuena; Ana Elisa Rozalén; Sergio Moreno Summary Serine 51 phosphorylation of the eukaryotic initiation factor-2α (eIF2α) is an important mechanism involved in blocking general protein synthesis in response to diverse types of stress. In fission yeast, three kinases (Hri1, Hri2 and Gcn2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4047–4054.
Published: 15 December 2008
... and hydrogen peroxide induce phosphorylation of eIF2α, a known Gcn2 target, and an arrest in G1 phase. By contrast, exposure to psoralen plus long-wavelength ultraviolet light, inducing DNA adducts and crosslinks, or to ionizing radiation induce neither eIF2α phosphorylation nor a cell-cycle delay. We conclude...
Includes: Supplementary data