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Keywords: eIF2α
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Journal Articles
J Cell Sci (2022) 135 (21): jcs259734.
Published: 31 October 2022
... on pharyngeal arch deficiency and found that pharyngeal arches in hspa8 mutant embryos exhibited induction of endoplasmic reticulum stress and activation of the unfolded protein response via the Perk/p-eIF2α/Atf4 signaling cascade. Inhibition of Perk/p-eIF2α/Atf4 signaling rescued the developmental deficiency...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259629.
Published: 26 July 2022
.... Mechanistically, VRB and cortisone signaled through the integrated stress response mediated by eIF2α (also known as EIF2S1), yet induced different kinases, with cortisone activating the GCN2 kinase (also known as EIF2AK4). Cortisone increased VRB-induced cell death and reduced the population of cells trapped...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs217216.
Published: 15 February 2019
... and fish to mammals, the UPR is mediated by the three well-known ER stress sensor molecules: inositol requiring 1 (IRE1), pancreatic ER eIF2α kinase (PERK), and activating transcription factor 6 (ATF6). Upon sensing the presence of unfolded proteins inside the ER, these sensors activate downstream...
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 5 October 2018
...Lucas C. Reineke; Shebna A. Cheema; Julien Dubrulle; Joel R. Neilson ABSTRACT Stress granules (SGs) assemble under stress-induced conditions that inhibit protein synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins or inactivation of mTORC1. Classically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 927–937.
Published: 1 March 2017
... and composition of stress granule-like foci, the translation-related mechanisms of their assembly and their connection to cell survival. Haploid cell Translational control Stress response Stress granules Translation initiation eIF2α During stress, translational control allows for the rapid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4420–4427.
Published: 1 December 2015
...Jon Halvor Jonsrud Knutsen; Gro Elise Rødland; Cathrine Arnason Bøe; Tine Weise Håland; Per Sunnerhagen; Beáta Grallert; Erik Boye ABSTRACT Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α...
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (24): 5955–5959.
Published: 15 December 2012
...Noelia Valbuena; Ana Elisa Rozalén; Sergio Moreno Summary Serine 51 phosphorylation of the eukaryotic initiation factor-2α (eIF2α) is an important mechanism involved in blocking general protein synthesis in response to diverse types of stress. In fission yeast, three kinases (Hri1, Hri2 and Gcn2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4047–4054.
Published: 15 December 2008
... and hydrogen peroxide induce phosphorylation of eIF2α, a known Gcn2 target, and an arrest in G1 phase. By contrast, exposure to psoralen plus long-wavelength ultraviolet light, inducing DNA adducts and crosslinks, or to ionizing radiation induce neither eIF2α phosphorylation nor a cell-cycle delay. We conclude...
Includes: Supplementary data