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Keywords: differentiation
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Journal Articles
Journal Articles
J Cell Sci (2023) 136 (9): jcs260454.
Published: 5 May 2023
... role in the choice between distinct forms of mitotic arrest – reversible quiescence and terminal differentiation, which play distinct roles in tissue homeostasis. We outline evidence implicating the centrosome–basal body switch in stem cell function, including how the cilium–centrosome complex...
Journal Articles
J Cell Sci (2022) 135 (20): jcs260594.
Published: 26 October 2022
...Erez Cohen; Craig Johnson; Catherine J. Redmond; Raji R. Nair; Pierre A. Coulombe ABSTRACT A large group of keratin genes ( n =54 in the human genome) code for intermediate filament (IF)-forming proteins and show differential regulation in epithelial cells and tissues. Keratin expression can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs259307.
Published: 10 December 2021
... organizer CTCF in regulating expression of the HOXA gene locus during differentiation. ChIP sequencing revealed a significant overlap between Nup93 and CTCF peaks. Interestingly, Nup93 and CTCF are associated with the 3′ and 5′ HOXA genes, respectively. Depletions of Nup93 and CTCF antagonistically modulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... chondrocyte quiescence and immature chondrocyte state through reducing the amount of H3K9me3-marked heterochromatin. Chondrocyte Differentiation Heterochromatin Hydrostatic pressure Mechanotransduction Nucleus Replicative stress The ends of long bones at the regions of joints are covered...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (24): jcs247841.
Published: 23 December 2020
... mechanistic evidence indicating that ubiquitin carboxyl-terminal hydrolase 8 (USP8) modulates BDNF- and TrkB-dependent neuronal differentiation. USP8 binds to the C-terminus of TrkB using its microtubule-interacting domain (MIT). Immunopurified USP8 deubiquitylates TrkB in vitro , whereas knockdown of USP8...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (24): jcs247841.
Published: 23 December 2020
... mechanistic evidence indicating that ubiquitin carboxyl-terminal hydrolase 8 (USP8) modulates BDNF- and TrkB-dependent neuronal differentiation. USP8 binds to the C-terminus of TrkB using its microtubule-interacting domain (MIT). Immunopurified USP8 deubiquitylates TrkB in vitro , whereas knockdown of USP8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (16): jcs230490.
Published: 27 August 2019
.... In line with this, CXCL2 overexpression attenuated proliferation, as well as differentiation, of osteoblasts in vitro . By contrast, CXCL2 downregulation promoted osteoblast expansion and differentiation. Mechanistically, CXCL2 inhibits the ERK1/2 (MAPK3/1) signaling pathway in osteoblasts. Activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230490.
Published: 27 August 2019
.... In line with this, CXCL2 overexpression attenuated proliferation, as well as differentiation, of osteoblasts in vitro . By contrast, CXCL2 downregulation promoted osteoblast expansion and differentiation. Mechanistically, CXCL2 inhibits the ERK1/2 (MAPK3/1) signaling pathway in osteoblasts. Activation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
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Polarity
J Cell Sci (2018) 131 (24): jcs219204.
Published: 17 December 2018
... structural variations that result in a remarkable repertoire of diverse compounds. This diversity of GSLs is exploited during embryogenesis, when different GSLs are produced at specific developmental stages and along several differentiation trajectories. Importantly, plasma membrane receptors interact...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (24): jcs219204.
Published: 17 December 2018
... structural variations that result in a remarkable repertoire of diverse compounds. This diversity of GSLs is exploited during embryogenesis, when different GSLs are produced at specific developmental stages and along several differentiation trajectories. Importantly, plasma membrane receptors interact...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3740–3748.
Published: 1 November 2017
... regulation in neuroendocrine differentiated cells. This point mutation altered the promoter's regulatory mechanism by discrete changes in transcription factor TR occupancy and altered enrichment of the repressive chromatin modification of histone-3-lysine-9-trimethyl (H3K9Me3). Insights relating...