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Keywords: desmosomes
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Journal Articles
J Cell Sci (2021) 134 (21): jcs258418.
Published: 5 November 2021
..., ablation of ET-20 lncRNA effectively blocks Tnc expression and with it EMT. Mechanistically, ET-20 interacts with desmosomal proteins, thereby impairing epithelial desmosomes and promoting EMT. A short transcript variant of ET-20 is shown to be upregulated in invasive human breast cancer cell lines, where...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238295.
Published: 16 April 2020
...Lisa Müller; Katrin Rietscher; René Keil; Marvin Neuholz; Mechthild Hatzfeld ABSTRACT Desmosome remodeling is crucial for epidermal regeneration, differentiation and wound healing. It is mediated by adapting the composition, and by post-translational modifications, of constituent proteins. We have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs212191.
Published: 22 May 2018
...Katrin Rietscher; René Keil; Annemarie Jordan; Mechthild Hatzfeld ABSTRACT Desmosomes are essential for strong intercellular adhesion and are abundant in tissues exposed to mechanical strain. At the same time, desmosomes need to be dynamic to allow for remodeling of epithelia during differentiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3437–3445.
Published: 15 October 2017
... mutations promulgate a mechanical role for this important cytoskeletal component. In stratified epithelia, keratin filaments form prominent radial spokes that are focused onto cell-cell contact sites, i.e. the desmosomes. In this Hypothesis, we draw attention to a subset of keratin filaments...
Journal Articles
J Cell Sci (2014) 127 (11): 2507–2517.
Published: 1 June 2014
...Andrew R. Harris; Alicia Daeden; Guillaume T. Charras ABSTRACT Adherens junctions and desmosomes integrate the cytoskeletons of adjacent cells into a mechanical syncitium. In doing so, intercellular junctions endow tissues with the strength needed to withstand the mechanical stresses encountered...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3202–3209.
Published: 1 July 2012
... cadherin- and integrin-based adhesion structures and hence epidermal function. In this study, we show that a member of this family, Rnd3, regulates desmosomal cell–cell adhesion in that loss of Rnd3 expression leads to an increase in desmosomes at sites of cell–cell adhesion and altered colony morphology...
Journal Articles
J Cell Sci (2012) 125 (7): 1750–1758.
Published: 1 April 2012
... epidermal keratins K5/K14, and electron microscopy revealed total absence of IFs in the suprabasal epidermis. Although plakoglobin was unchanged, the expression of the desmosomal proteins desmoplakin, desmocollin 1 and desmoglein 1 were altered and suprabasal desmosomes were smaller in Krt1 −/− ; Krt10...
Journal Articles
J Cell Sci (2011) 124 (5): 745–754.
Published: 1 March 2011
... of the ameloblast–SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation. The reduced size of desmosomes in Perp -null teeth contrasts with the slightly increased desmosome size in the skin of Perp -null mice (Ihrie et al., 2005). The reasons...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3561–3569.
Published: 1 November 2008
...Lisa M. Sevilla; Rachida Nachat; Karen R. Groot; Fiona M. Watt Kazrin is an evolutionarily conserved protein that is upregulated during keratinocyte terminal differentiation. Kazrin localizes to desmosomes and binds the epidermal cornified envelope protein periplakin. Kazrin overexpression in human...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (17): 2844–2849.
Published: 1 September 2008
...Jiangli Chen; Zhining Den; Peter J. Koch Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified epithelia, such as the epidermis. Based on its amino acid sequence homology to classical cadherins, such as E-cadherin, it has been...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (16): 3303–3314.
Published: 15 August 2003
...Andrew P. South; Hong Wan; Michael G. Stone; Patricia J. C. Dopping-Hepenstal; Patricia E. Purkis; John F. Marshall; Irene M. Leigh; Robin A. J. Eady; Ian R. Hart; John A. McGrath Ablation of the desmosomal plaque component plakophilin 1 underlies the autosomal recessive genodermatosis, skin...
Journal Articles
Journal Articles
J Cell Sci (1993) 104 (3): 741–750.
Published: 1 March 1993
...Joachim Arnemann; Kate H. Sullivan; Anthony I. Magee; Ian A. King; Roger S. Buxton ABSTRACT Desmosomal junctions are abundant in epidermis and contain two classes of transmembrane glycoprotein, the desmocollins and the desmogleins, which are members of the cadherin superfamily of Ca 2+ -dependent...
Journal Articles
J Cell Sci (1992) 103 (2): 463–473.
Published: 1 October 1992
...P. Bogner; P. Skehan; S. Kenney; E. Sainz; M.A. Akeson; S. J. Friedman ABSTRACT Short-chain monocarboxylic acids (MCAs) selectively protect desmosomal junctions of MDCK cells from disruption by chelating agents and low calcium medium. This effect occurs in the millimolar concentration range...
Journal Articles
J Cell Sci (1992) 103 (1): 69–80.
Published: 1 September 1992
...Katrina T. Trevor; Lara S. Steben ABSTRACT In diverse epithelia, cytoskeletal keratin intermediate filaments (IFs) associate with the cytoplasmic face of intercelluar junctional desmosomes. The processes underlying desmosome formation and keratin IF interactions remain unclear. We have examined F9...
Journal Articles
J Cell Sci (1990) 97 (4): 689–704.
Published: 1 December 1990
...D. L. Mattey; G. Burdge; D. R. Garrod ABSTRACT The development or maturation of intercellular adhesions following their initiation has received very little attention even though this is an area of significance for a variety of in vivo processes. Using Ca 2+ -induced desmosome formation in MDCK...
Journal Articles
J Cell Sci (1990) 97 (2): 239–246.
Published: 1 October 1990
...J. L. Holton; T. P. Kenny; P. K. Legan; J. E. Collins; J. N. Keen; R. Sharma; D. R. Garrod ABSTRACT The N-terminal sequence of a mixture of desmosomal glycoproteins 2 and 3 (dg2/3, desmocollins) from bovine nasal epidermis, prepared by electro-elution from polyacrylamide gels, was determined...
Journal Articles
J Cell Sci (1990) 96 (2): 239–248.
Published: 1 June 1990
...E. P. Parrish; J. E. Marston; D. L. Mattey; H. R. Measures; R. Venning; D. R. Garrod ABSTRACT Metabolic labelling with [ 35 S]methionine and immu-noprecipitation with specific antibodies to bovine desmosomal glycoproteins 2 and 3 (dg2 and dg3: desmocollins) reveals a triplet of polypeptides of M r...