...Martin Harterink; Stacey L. Edwards; Bart de Haan; Kah Wai Yau; Sander van den Heuvel; Lukas C. Kapitein; Kenneth G. Miller; Casper C. Hoogenraad ABSTRACT The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal...

...Brian V. Jenkins; Harriet A. J. Saunders; Helena L. Record; Dena M. Johnson-Schlitz; Jill Wildonger ABSTRACT Microtubules are essential for neuronal structure and function. Axonal and dendritic microtubules are enriched in post-translational modifications that impact microtubule dynamics, transport...

...Yun Peng; Jiae Lee; Kimberly Rowland; Yuhui Wen; Hope Hua; Nicole Carlson; Shweta Lavania; Jay Z. Parrish; Michael D. Kim ABSTRACT Dendrites lengthen by several orders of magnitude during neuronal development, but how membrane is allocated in dendrites to facilitate this growth remains unclear...

...José I. Valenzuela; Matías Jaureguiberry-Bravo; Daniela A. Salas; Omar A. Ramírez; Víctor H. Cornejo; Hsiangmin E. Lu; Thomas A. Blanpied; Andrés Couve ABSTRACT In neurons, secretory organelles within the cell body are complemented by the dendritic endoplasmic reticulum (ER) and Golgi outposts...

...Srividya Chandramouli Iyer; Eswar P. Ramachandran Iyer; Ramakrishna Meduri; Myurajan Rubaharan; Aravinda Kuntimaddi; Madhu Karamsetty; Daniel N. Cox Summary Dendrite development is crucial in the formation of functional neural networks. Recent studies have provided insights into the involvement...

.... In the current study, we show that endogenous centaurin α1 protein is localized in the synaptosome fraction, with peak expression in early postnatal development. In cultured dissociated hippocampal neurons, centaurin α1 localizes to dendrites, dendritic spines and the postsynaptic region. siRNA-mediated...

...Henrietta Nyman-Huttunen; Li Tian; Lin Ning; Carl G. Gahmberg Intercellular adhesion molecule-5 (ICAM-5, telencephalin) is a dendrite-expressed membrane glycoprotein of telencephalic neurons in the mammalian brain. By deletion of the cytoplasmic and membrane-spanning domains of ICAM-5, we observed...

...Hiroshi Kimura; Tadao Usui; Asako Tsubouchi; Tadashi Uemura Seven-pass transmembrane cadherins (7-TM cadherins) play pleiotropic roles in epithelial planar cell polarity, shaping dendritic arbors and in axonal outgrowth. In contrast to their role in planar polarity, how 7-TM cadherins control...

... of ER in the dendrite of living neurons still remain unknown. To elucidate these, we expressed fluorescent protein-tagged ER proteins in cultured mouse hippocampal neurons, and monitored their movements using time-lapse microscopy. We report here that a sub-compartment of ER forms in relatively large...

...Yuji Ikegaya; Jeong-Ah Kim; Minami Baba; Takeshi Iwatsubo; Nobuyoshi Nishiyama; Norio Matsuki Postsynaptic neuronal dendrites undergo functional and morphological changes in response to pathologically excessive synaptic activation. Although rapid formation of segmental focal swelling (varicosity...

... filament formation in ABCs is associated with a distinctive pattern of dendritic degeneration that closely resembles the cytopathology of human neurofibrillary degenerative disease. This pattern includes localized cytoskeletal disruption and aggregation of membranous organelles, distal dendritic beading...

... of dendritic development and the formation of fewer synapses than in non-treated or sense-treated neurons. Moreover, this decreased synaptic density is accompanied by a selective inhibition of the clustering of GABA receptors. These results lead to the conclusion that agrin may be an important regulator...

...Caroline C. Overly; Heather I. Rieff; Peter J. Hollenbeck ABSTRACT Regional regulation of organelle transport seems likely to play an important role in establishing and maintaining distinct axonal and dendritic domains in neurons, and in managing differences in local metabolic demands. In addition...

...Kenneth S. Kosik; Alfredo Caceres ABSTRACT Dissociated neuronal cultures from several regions of the nervous system elaborate two populations of neurites which have features of axons and dendrites. The microtubule-associated protein tau appears to segregate to the axon in some of these culture...