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Keywords: cyclin
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Journal Articles
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Autophagy
J Cell Sci (2020) 133 (17): jcs247817.
Published: 9 September 2020
... the early phases of the nitrogen starvation response. This excessive TORC1 reactivation results in the silencing of the Ste11-Mei2 pathway and mating defects. Additionally, we found that pef1 genetically interacts with tsc1 and tsc2 for TORC1 regulation, and physically interacts with three cyclins, Clg1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235721.
Published: 17 March 2020
...Yang Ma; Guanxiong Yan; Xiaojie Han; Jing Zhang; Jie Xiong; Wei Miao ABSTRACT To investigate the mechanisms underlying initiation of the sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) in the well-studied model ciliate, Tetrahymena thermophila . We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1108–1115.
Published: 1 April 2010
...Nikki A. Copeland; Heather E. Sercombe; Justin F. X. Ainscough; Dawn Coverley Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs). Under these conditions, cyclin E supports pre...
Journal Articles
J Cell Sci (2009) 122 (22): 4208–4217.
Published: 15 November 2009
...Reinhard Sigl; Cornelia Wandke; Veronika Rauch; Jane Kirk; Tim Hunt; Stephan Geley The anaphase-promoting complex/cyclosome (APC/C) is essential for progression through mitosis. At anaphase onset, the APC/C requires the activator protein CDC20 to target securin and cyclin B1 for proteasome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (14): 2319–2326.
Published: 15 July 2008
...Adam Walker; Claire Acquaviva; Takahiro Matsusaka; Lars Koop; Jonathon Pines Ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase lies at the heart of the cell cycle. The APC/C targets mitotic cyclins for destruction in mitosis and G1 phase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2390–2401.
Published: 15 July 2007
... is not due to a defect in the recruitment of the polarisome scaffold protein Spa2 or the actin cytoskeleton regulators Cdc42 and Cdc24 in the neck region. Previous results indicate a connection between Rot1 and the cyclin Clb2. In fact, overexpression of CLB2 is toxic when ROT1 is partially inactivated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 702–711.
Published: 15 February 2007
...Raïssa Eluère; Nicolas Offner; Isabelle Varlet; Olivia Motteux; Laurence Signon; André Picard; Eric Bailly; Marie-Noëlle Simon Orderly progression through the eukaryotic cell cycle is a complex process involving both regulation of cyclin dependent kinase activity and control of specific...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (16): 3571–3578.
Published: 15 July 2004
... is therefore first required after egg activation for polar body condensation and zygotic mitoses. Embryos containing pronounced anterior-posterior gradients of Gnu activity demonstrate that Gnu regulates mitotic activity by promoting cyclin B stability. Our gnuGFP-bcd3 ′ UTR vector provides a novel...
Journal Articles
J Cell Sci (2002) 115 (23): 4393–4397.
Published: 1 December 2002
.... Morata for the hh-GAL4 flies used for making Fig. 2 . References Barnes, E. A., Kong, M., Ollendorff, V. and Donoghue, D. J. ( 2001 ). Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 , 2214 -2223. Bhardwaj, G., Murdoch, B., Wu, D., Baker, D. P., Williams...
Journal Articles
J Cell Sci (2002) 115 (12): 2461–2464.
Published: 15 June 2002
...Marcel Dorée; Tim Hunt The idea that Cdc2 and cyclins play a key role in the control of the G2/M transition of the cell cycle came largely from genetic analysis of fission yeast and physiological studies of clam, frog, sea urchin and starfish eggs and oocytes. However, it took a long time...
Journal Articles
J Cell Sci (2002) 115 (1): 113–121.
Published: 1 January 2002
...Bradley J. Schnackenberg; William F. Marzluff In somatic cells, cyclin E-cdk2 activity oscillates during the cell cycle and is required for the regulation of the G1/S transition. Cyclin E and its associated kinase activity remain constant throughout early sea urchin embryogenesis, consistent...
Journal Articles
J Cell Sci (2001) 114 (24): 4599–4611.
Published: 15 December 2001
...Nicholas P. Edgington; Bruce Futcher The Saccharomyces cerevisiae cyclin-dependent kinase Cdc28 forms complexes with nine different cyclins to promote cell division. These nine cyclin-Cdc28 complexes have different roles, but share the same catalytic subunit; thus, it is not clear how substrate...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 69–73.
Published: 1 January 1994
...Steven I. Reed; Eric Bailly; Vjekoslav Dulic; Ludger Hengst; Dalia Resnitzky; Joyce Slingerland SUMMARY Cyclin-dependent kinases (Cdks) control the major cell cycle transitions in eukaryotic cells. On the basis of a variety of experiments where cyclin function either is impaired or enhanced, D-type...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 77–85.
Published: 1 January 1992
...LASANTHA R. BANDARA; JÖRG P. ADAMCZEWSKI; MARYAM ZAMANIAN; RANDY Y. C. POON; TIM HUNT; NICHOLAS B. LA THANGUE Summary Cyclins are regulatory molecules that undergo periodic accumulation and destruction during each cell cycle. By activating p34 cdc2 and related kinase subunits they control important...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 9–19.
Published: 1 February 1989
...CAROLINE E. ALFA; ROBERT BOOHER; DAVID BEACH; JEREMY S. HYAMS Summary Entry into mitosis in the fission yeast Schizosaccharomyces pombe involves the interaction of a number of genes with the major cell cycle control gene, cdc2 + . One of these, cdc13 + , encodes a protein with homology to cyclin...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 99–116.
Published: 1 February 1989
... occurs in two stages. The first stage requires protein synthesis, whereas the second does not. The second stage of activation involves post-translational activation of the kinase. Kinase activity rises to a peak and then abruptly disappears. Added sea urchin cyclin is degraded at the time...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 129–144.
Published: 1 February 1989
..., as it does in fertilized embryos. Cyclins are proteins that are synthesized throughout the cell cycle and destroyed abruptly during each round of chromatin condensation. We find that cycles of cyclin phosphorylation and destruction occur coincident with chromatin condensation in ammonia-activated eggs...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 277–291.
Published: 1 February 1989
..., the maternally-provided determinants for pole cell formation. The pole cells form the germ-line of the developing organism, and as such may have specific requirements for mitotic cell division. This is suggested by our finding that a specific class of cyclin mRNAs, the products of the cyclin B gene, accumulate...